EXD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXD1_HUMAN
• UniProt AC: Q8NHP7
• Protein Name: piRNA biogenesis protein EXD1 {ECO:0000305}
• Gene Name: EXD1
• Organism: Homo sapiens (Human).
• Sequence Length: 514
• Subcellular Localization: Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity)..
• Protein Sequence: MEDSEFLAYVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPATSLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLSVAAEGANVCRHGKLCWLQVATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKYLSFLEKRQKLIQENPEVWFIRPVSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYLNTYREGSADRLGGTEPTCMELPEELLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTETAGKEEKVKGFLFGKNFRIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSEDSSNKLICTKSKGSEDQRITQKEHFMTPKHEFQASLSLKEETEQLLMVENKEDLKCTKQAVSMSSFPQETRVSPSDTFYPIRKTVVSTLPPCPALEKIDSWISPFLNLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Ubiquitination	EEEEVTYTVINQFQQ CCHHHHHHHHHHHHH	12.92	20639865
82	Ubiquitination	EVTYTVINQFQQKFG HHHHHHHHHHHHHHC	32.07	22817900
102	Phosphorylation	IKKQNVLSVAAEGAN EHHCCEEEEEECCCC	12.86	26270265
188	Ubiquitination	TQVADVLQFSMETGG HHHHHHHHHHHHCCC	28.37	20639865
191	Ubiquitination	ADVLQFSMETGGYLP HHHHHHHHHCCCCCC	5.88	22817900
207	Phosphorylation	CITTLQESLIKHLQV HHHHHHHHHHHHHHH	23.57	24719451
224	Ubiquitination	KYLSFLEKRQKLIQE HHHHHHHHHHHHHHH	63.38	20639865
227	Ubiquitination	SFLEKRQKLIQENPE HHHHHHHHHHHHCCC	52.14	22817900
228	Ubiquitination	FLEKRQKLIQENPEV HHHHHHHHHHHCCCC	3.55	20639865
231	Ubiquitination	KRQKLIQENPEVWFI HHHHHHHHCCCCEEE	68.69	22817900
244	Phosphorylation	FIRPVSPSLLKILAL EEEECCHHHHHHHHH	38.54	24719451
247	Ubiquitination	PVSPSLLKILALEAT ECCHHHHHHHHHHHH	40.75	20639865
250	Ubiquitination	PSLLKILALEATYLL HHHHHHHHHHHHHHH	13.56	22817900
259	Ubiquitination	EATYLLPLRLALLDE HHHHHHHHHHHHHHH	7.66	20639865
262	Ubiquitination	YLLPLRLALLDEMMS HHHHHHHHHHHHHHH	10.31	22817900
272	Phosphorylation	DEMMSDLTTLVDGYL HHHHHHHHHHHHHHH	24.07	-
282	Ubiquitination	VDGYLNTYREGSADR HHHHHHHHCCCCCCC	12.95	20639865
285	Ubiquitination	YLNTYREGSADRLGG HHHHHCCCCCCCCCC	21.09	22817900
407	Phosphorylation	EGETSEDSSNKLICT CCCCCCCCCCCEEEE	31.59	24260401
440	Phosphorylation	PKHEFQASLSLKEET CHHHHHHCCCCHHHH	14.01	24719451
442	Phosphorylation	HEFQASLSLKEETEQ HHHHHCCCCHHHHHH	34.59	24719451
456	Acetylation	QLLMVENKEDLKCTK HHEEECCHHHHCCCC	38.82	21466224
460	Acetylation	VENKEDLKCTKQAVS ECCHHHHCCCCHHHH	52.78	21466224
462	Phosphorylation	NKEDLKCTKQAVSMS CHHHHCCCCHHHHCC	25.30	-
470	Phosphorylation	KQAVSMSSFPQETRV CHHHHCCCCCCCCCC	32.10	28509920
475	Phosphorylation	MSSFPQETRVSPSDT CCCCCCCCCCCCCCC	30.99	-
478	Phosphorylation	FPQETRVSPSDTFYP CCCCCCCCCCCCCCE	18.52	30242111
480	Phosphorylation	QETRVSPSDTFYPIR CCCCCCCCCCCCEEH	41.60	30242111
482	Phosphorylation	TRVSPSDTFYPIRKT CCCCCCCCCCEEHHH	29.43	30242111
484	Phosphorylation	VSPSDTFYPIRKTVV CCCCCCCCEEHHHHH	10.39	30242111
514	Acetylation	ISPFLNLP------- HHHHHCCC-------	40.88	-
518	Acetylation	LNLP----------- HCCC-----------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EXD1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.