GHRL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GHRL_HUMAN
• UniProt AC: Q9UBU3
• Protein Name: Appetite-regulating hormone
• Gene Name: GHRL
• Organism: Homo sapiens (Human).
• Sequence Length: 117
• Subcellular Localization: Secreted.
• Protein Description: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity)..
• Protein Sequence: MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 3)	Phosphorylation	-	34.36	-
3 (in isoform 4)	Phosphorylation	-	34.36	-
3 (in isoform 5)	Phosphorylation	-	34.36	-
26	Acetylation	DLAMAGSSFLSPEHQ HHHHHCCCCCCHHHH	29.32	10604470
26	Decanoylation	DLAMAGSSFLSPEHQ HHHHHCCCCCCHHHH	29.32	12414809
26	Octanoylation	DLAMAGSSFLSPEHQ HHHHHCCCCCCHHHH	29.32	12414809
26	Octanoylation	DLAMAGSSFLSPEHQ HHHHHCCCCCCHHHH	29.32	12414809
41	Phosphorylation	RVQQRKESKKPPAKL HHHHHHHHCCCCCCC	49.35	18343535
91	Phosphorylation	IKLSGVQYQQHSQAL EEECCCCHHHHHHHH	14.03	29449344
95	Phosphorylation	GVQYQQHSQALGKFL CCCHHHHHHHHHHHH	16.89	29449344
98	Leucine amide	YQQHSQALGKFLQDI HHHHHHHHHHHHHHH	6.25	-
98	Amidation	YQQHSQALGKFLQDI HHHHHHHHHHHHHHH	6.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	S	Phosphorylation	Kinase	PRKCB	P05771-2	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
98	L	Amidation	Amidation of Leu-98 is essential for obestatin activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GHRL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PI2R_HUMAN	PTGIR	physical	18573679
TA2R_HUMAN	TBXA2R	physical	18573679
PE2R3_HUMAN	PTGER3	physical	18573679

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.