PE2R3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PE2R3_HUMAN
• UniProt AC: P43115
• Protein Name: Prostaglandin E2 receptor EP3 subtype
• Gene Name: PTGER3
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity)..
• Protein Sequence: MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKETRGYGGDAPFC -CCCCCCCCCCCCCC	18.04	-
15	Phosphorylation	GGDAPFCTRLNHSYT CCCCCCCCCCCCCCC	38.27	-
18	N-linked_Glycosylation	APFCTRLNHSYTGMW CCCCCCCCCCCCCCC	20.83	UniProtKB CARBOHYD
36	N-linked_Glycosylation	RSAEARGNLTRPPGS CCHHHCCCCCCCCCC	32.46	UniProtKB CARBOHYD
57	Phosphorylation	VSVAFPITMLLTGFV CCHHHHHHHHHHCHH	11.29	22210691
74	Phosphorylation	ALAMLLVSRSYRRRE HHHHHHHHHHHHHHH	18.58	24719451
76	Phosphorylation	AMLLVSRSYRRRESK HHHHHHHHHHHHHHH	18.58	22210691
77	Phosphorylation	MLLVSRSYRRRESKR HHHHHHHHHHHHHHC	13.66	22210691
107	Phosphorylation	LVGQLLTTPVVIVVY HHHHHHCCCEEEEEE	17.66	-
403 (in isoform 12)	Phosphorylation	-		22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PE2R3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PE2R3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PE2R3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKLN1_HUMAN	MKLN1	physical	11006128
GHRL_HUMAN	GHRL	physical	18573679
REL_HUMAN	REL	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
RGS20_HUMAN	RGS20	physical	25416956
KRT38_HUMAN	KRT38	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
RGS17_HUMAN	RGS17	physical	25416956
FBLN4_HUMAN	EFEMP2	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
MGT5B_HUMAN	MGAT5B	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
PKP4_HUMAN	PKP4	physical	26186194
PK3CB_HUMAN	PIK3CB	physical	26186194
EI2BE_HUMAN	EIF2B5	physical	26186194
LSR_HUMAN	LSR	physical	26186194
EI2BA_HUMAN	EIF2B1	physical	26186194
CAND2_HUMAN	CAND2	physical	26186194
TBC15_HUMAN	TBC1D15	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
SL9A1_HUMAN	SLC9A1	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
ZCH18_HUMAN	ZC3H18	physical	26186194
KTN1_HUMAN	KTN1	physical	26186194
FACD2_HUMAN	FANCD2	physical	26186194
IPO9_HUMAN	IPO9	physical	26186194
MFAP3_HUMAN	MFAP3	physical	26186194
SAAL1_HUMAN	SAAL1	physical	26186194
GEMI4_HUMAN	GEMIN4	physical	26186194
PKHH3_HUMAN	PLEKHH3	physical	26186194
AVR2B_HUMAN	ACVR2B	physical	26186194
AVR2A_HUMAN	ACVR2A	physical	26186194
DIP2A_HUMAN	DIP2A	physical	26186194
EI2BD_HUMAN	EIF2B4	physical	26186194
XPO4_HUMAN	XPO4	physical	26186194
LRIG3_HUMAN	LRIG3	physical	26186194
TMED8_HUMAN	TMED8	physical	26186194
RETST_HUMAN	RETSAT	physical	26186194
DHRS7_HUMAN	DHRS7	physical	26186194
CWC22_HUMAN	CWC22	physical	26186194
ARL10_HUMAN	ARL10	physical	26186194
PININ_HUMAN	PNN	physical	26186194
IPO8_HUMAN	IPO8	physical	26186194
RHDF2_HUMAN	RHBDF2	physical	26186194
CIP2A_HUMAN	KIAA1524	physical	26186194
RNPS1_HUMAN	RNPS1	physical	26186194
OSBL8_HUMAN	OSBPL8	physical	26186194
CP51A_HUMAN	CYP51A1	physical	26186194
IPO11_HUMAN	IPO11	physical	26186194
PBIP1_HUMAN	PBXIP1	physical	26186194
FARP2_HUMAN	FARP2	physical	26186194
PLD2_HUMAN	PLD2	physical	26186194
TYW1B_HUMAN	TYW1B	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
P85B_HUMAN	PIK3R2	physical	26186194
P85A_HUMAN	PIK3R1	physical	26186194
PKN3_HUMAN	PKN3	physical	26186194
GCP2_HUMAN	TUBGCP2	physical	26186194
NOP9_HUMAN	NOP9	physical	26186194
DOCK7_HUMAN	DOCK7	physical	26186194
HYEP_HUMAN	EPHX1	physical	26186194
PKP2_HUMAN	PKP2	physical	26186194
ECD_HUMAN	ECD	physical	26186194
S39A1_HUMAN	SLC39A1	physical	26186194
TNPO2_HUMAN	TNPO2	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
BMR1A_HUMAN	BMPR1A	physical	26186194
UBF1_HUMAN	UBTF	physical	26186194
EI2BB_HUMAN	EIF2B2	physical	26186194
EXOC2_HUMAN	EXOC2	physical	26186194
ERBB2_HUMAN	ERBB2	physical	26186194
AP3B1_HUMAN	AP3B1	physical	26186194
MIGA1_HUMAN	FAM73A	physical	26186194
VGFR3_HUMAN	FLT4	physical	26186194
EI2BG_HUMAN	EIF2B3	physical	26186194
M4K4_HUMAN	MAP4K4	physical	26186194
AN13D_HUMAN	ANKRD13D	physical	26186194
RAB18_HUMAN	RAB18	physical	26186194
STAG1_HUMAN	STAG1	physical	26186194
HOOK2_HUMAN	HOOK2	physical	26186194
ARMX3_HUMAN	ARMCX3	physical	26186194
LEG1_HUMAN	LGALS1	physical	26186194
EVI5L_HUMAN	EVI5L	physical	26186194
LMBR1_HUMAN	LMBR1	physical	26186194
VPS8_HUMAN	VPS8	physical	26186194
PLCB1_HUMAN	PLCB1	physical	26186194
VANG2_HUMAN	VANGL2	physical	26186194
CA112_HUMAN	C1orf112	physical	26186194
DYM_HUMAN	DYM	physical	26186194
ST7_HUMAN	ST7	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
PKHG4_HUMAN	PLEKHG4	physical	26186194
MYADM_HUMAN	MYADM	physical	26186194
PHLB3_HUMAN	PHLDB3	physical	26186194
CREL1_HUMAN	CRELD1	physical	26186194
CKLF4_HUMAN	CMTM4	physical	26186194
TMM94_HUMAN	KIAA0195	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
UBP46_HUMAN	USP46	physical	26186194
TMED8_HUMAN	TMED8	physical	28514442
PLCB1_HUMAN	PLCB1	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
RHDF2_HUMAN	RHBDF2	physical	28514442
HOOK2_HUMAN	HOOK2	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
TYW1B_HUMAN	TYW1B	physical	28514442
AN13D_HUMAN	ANKRD13D	physical	28514442
FARP2_HUMAN	FARP2	physical	28514442
PININ_HUMAN	PNN	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
EVI5L_HUMAN	EVI5L	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
DOCK7_HUMAN	DOCK7	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
PKP4_HUMAN	PKP4	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
TMM94_HUMAN	KIAA0195	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
VGFR3_HUMAN	FLT4	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
VPS8_HUMAN	VPS8	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
UBF1_HUMAN	UBTF	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
PKHH3_HUMAN	PLEKHH3	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
SAAL1_HUMAN	SAAL1	physical	28514442
P85B_HUMAN	PIK3R2	physical	28514442
CKLF4_HUMAN	CMTM4	physical	28514442
ZCH18_HUMAN	ZC3H18	physical	28514442
EI2BB_HUMAN	EIF2B2	physical	28514442
IPO8_HUMAN	IPO8	physical	28514442
EI2BA_HUMAN	EIF2B1	physical	28514442
PKHG4_HUMAN	PLEKHG4	physical	28514442
IPO7_HUMAN	IPO7	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
DIP2A_HUMAN	DIP2A	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
AVR2A_HUMAN	ACVR2A	physical	28514442
PK3CB_HUMAN	PIK3CB	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
ERBB2_HUMAN	ERBB2	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.