TMED8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMED8_HUMAN
• UniProt AC: Q6PL24
• Protein Name: Protein TMED8
• Gene Name: TMED8
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Protein Sequence: MSDLQAAEGPGSWSPTARPGSAGGVGDCQGVEGSQAAASENEDLENKDTSLLASATDPEPCSSPHRPQMVSPVSKDATEDLRKATGPLEAQALVKQDLLPADQAQVLNEMAKYQVPQRSGDIVMIQSEHTGAIDVLSADLESADLLGDHRKVSPPLMAPPCIWTFAKVKEFKSKLGKEKNSRLVVKRGEVVTIRVPTHPEGKRVCWEFATDDYDIGFGVYFDWTPVTSTDITVQVSDSSDDEDEEEEEEEEIEEPVPAGDVERGSRSSLRGRYGEVMPVYRRDSHRDVQAGSHDYPGEGIYLLKFDNSYSLLRNKTLYFHIYYTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDLQAAEG ------CCCCCCCCC	47.21	28270605
12	Phosphorylation	QAAEGPGSWSPTARP CCCCCCCCCCCCCCC	27.75	26074081
14	Phosphorylation	AEGPGSWSPTARPGS CCCCCCCCCCCCCCC	17.67	25849741
16	Phosphorylation	GPGSWSPTARPGSAG CCCCCCCCCCCCCCC	29.77	26074081
21	Phosphorylation	SPTARPGSAGGVGDC CCCCCCCCCCCCCCC	26.82	23401153
27	Ubiquitination	GSAGGVGDCQGVEGS CCCCCCCCCCCCCCC	21.11	29967540
34	Phosphorylation	DCQGVEGSQAAASEN CCCCCCCCHHCHHCC	11.79	26074081
39	Phosphorylation	EGSQAAASENEDLEN CCCHHCHHCCCCCCC	35.91	30576142
44	Ubiquitination	AASENEDLENKDTSL CHHCCCCCCCCCCCH	6.78	29967540
49	Phosphorylation	EDLENKDTSLLASAT CCCCCCCCCHHHCCC	23.92	20873877
50	Phosphorylation	DLENKDTSLLASATD CCCCCCCCHHHCCCC	31.36	25159151
54	Phosphorylation	KDTSLLASATDPEPC CCCCHHHCCCCCCCC	31.50	30576142
56	Phosphorylation	TSLLASATDPEPCSS CCHHHCCCCCCCCCC	49.98	28450419
62	Phosphorylation	ATDPEPCSSPHRPQM CCCCCCCCCCCCCCC	58.58	25159151
63	Phosphorylation	TDPEPCSSPHRPQMV CCCCCCCCCCCCCCC	31.29	25159151
71	Phosphorylation	PHRPQMVSPVSKDAT CCCCCCCCCCCCCHH	17.78	25159151
74	Phosphorylation	PQMVSPVSKDATEDL CCCCCCCCCCHHHHH	28.36	28450419
75	Acetylation	QMVSPVSKDATEDLR CCCCCCCCCHHHHHH	52.17	19821541
78	Phosphorylation	SPVSKDATEDLRKAT CCCCCCHHHHHHHHH	39.92	26074081
83	Ubiquitination	DATEDLRKATGPLEA CHHHHHHHHHCCHHH	58.56	29967540
85	Phosphorylation	TEDLRKATGPLEAQA HHHHHHHHCCHHHHH	42.22	27050516
95	Ubiquitination	LEAQALVKQDLLPAD HHHHHHHHCCCCCHH	38.66	29967540
110	Sulfoxidation	QAQVLNEMAKYQVPQ HHHHHHHHHCCCCCC	3.66	21406390
112	Ubiquitination	QVLNEMAKYQVPQRS HHHHHHHCCCCCCCC	34.60	29967540
113	Phosphorylation	VLNEMAKYQVPQRSG HHHHHHCCCCCCCCC	12.76	27642862
151	Ubiquitination	DLLGDHRKVSPPLMA HHHCCCCCCCCCCCC	43.58	29967540
153	Phosphorylation	LGDHRKVSPPLMAPP HCCCCCCCCCCCCCC	24.68	28450419
156	Ubiquitination	HRKVSPPLMAPPCIW CCCCCCCCCCCCCEE	5.33	29967540
169	Acetylation	IWTFAKVKEFKSKLG EEEHHHHHHHHHHHC	57.64	19608861
172	Acetylation	FAKVKEFKSKLGKEK HHHHHHHHHHHCCCC	48.01	19608861
181	Phosphorylation	KLGKEKNSRLVVKRG HHCCCCCCCEEEECC	37.75	-
192	Phosphorylation	VKRGEVVTIRVPTHP EECCCEEEEECCCCC	14.29	-
197	Phosphorylation	VVTIRVPTHPEGKRV EEEEECCCCCCCCEE	47.40	-
236	Ubiquitination	TDITVQVSDSSDDED CEEEEEECCCCCCCC	18.06	21890473
241	Ubiquitination	QVSDSSDDEDEEEEE EECCCCCCCCHHHHH	68.16	21890473
265	Phosphorylation	AGDVERGSRSSLRGR CCCCCCCCCHHHCCC	34.90	-
267	Phosphorylation	DVERGSRSSLRGRYG CCCCCCCHHHCCCCC	35.11	-
268	Phosphorylation	VERGSRSSLRGRYGE CCCCCCHHHCCCCCC	22.45	-
284	Phosphorylation	MPVYRRDSHRDVQAG EEEEECCCCCCCCCC	20.71	21406692
292	Phosphorylation	HRDVQAGSHDYPGEG CCCCCCCCCCCCCCE	19.05	21406692
295	Phosphorylation	VQAGSHDYPGEGIYL CCCCCCCCCCCEEEE	14.02	21406692
301	Phosphorylation	DYPGEGIYLLKFDNS CCCCCEEEEEEECCC	19.48	21406692
304	Ubiquitination	GEGIYLLKFDNSYSL CCEEEEEEECCCCHH	48.34	21890473
309	Ubiquitination	LLKFDNSYSLLRNKT EEEECCCCHHHCCCE	15.02	21890473
309	Phosphorylation	LLKFDNSYSLLRNKT EEEECCCCHHHCCCE	15.02	-
406	Ubiquitination	---------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMED8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMED8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMED8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMED8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-169, AND MASS SPECTROMETRY.
PubMed: 19608861