FARP2_HUMAN - dbPTM
FARP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FARP2_HUMAN
UniProt AC O94887
Protein Name FERM, ARHGEF and pleckstrin domain-containing protein 2
Gene Name FARP2
Organism Homo sapiens (Human).
Sequence Length 1054
Subcellular Localization
Protein Description Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity)..
Protein Sequence MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMGEIEGTYRVLQTAG
CCCCCHHHHHHHCCC		15.0225159151
22PhosphorylationGMRLGAQTPVGVSTL
CCCCCCCCCCCCCCC		21.2929255136
27PhosphorylationAQTPVGVSTLEPGQT
CCCCCCCCCCCCCCC		22.7329255136
28PhosphorylationQTPVGVSTLEPGQTL
CCCCCCCCCCCCCCC		32.5029255136
34PhosphorylationSTLEPGQTLLPRMQE
CCCCCCCCCHHHHHH		35.8627732954
49UbiquitinationKHLHLRVKLLDNTME
HCCHHEEECCCCCEE		36.58-
104UbiquitinationIWLEPMKPIIRQIRR
EEEEECHHHHHHHCC		22.4627667366
145UbiquitinationYLFALQLKRDLLEER
HHHHHHHHHHHHHHH		30.7929967540
145UbiquitinationYLFALQLKRDLLEER
HHHHHHHHHHHHHHH		30.79-
185UbiquitinationTLDREHLKVNEYLPG
HCCHHHCCHHHCCCC		44.9429967540
199UbiquitinationGQQHCLEKILEFHQK
CHHHHHHHHHHHHHH		39.3829967540
206UbiquitinationKILEFHQKHVGQTPA
HHHHHHHHHCCCCCC		31.5229967540
229PhosphorylationIARKLEMYGIRFHMA
HHHHHHHHCCEEEEC		10.4628555341
245UbiquitinationDREGTKIQLAVSHMG
CCCCCEEEEEECCCC		25.5627667366
274PhosphorylationWSKVRKLSFKRKRFL
HHHHEEEECCCCEEE		31.5824719451
282UbiquitinationFKRKRFLIKLHPEVH
CCCCEEEEECCCCCC		4.0327667366
331UbiquitinationDQPKPKAKAVFFSRG
CCCCCCCEEEEEECC		51.7327667366
331UbiquitinationDQPKPKAKAVFFSRG
CCCCCCCEEEEEECC		51.73-
336PhosphorylationKAKAVFFSRGSSFRY
CCEEEEEECCCCCCC		25.0221712546
337MethylationAKAVFFSRGSSFRYS
CEEEEEECCCCCCCC		43.80-
339PhosphorylationAVFFSRGSSFRYSGR
EEEEECCCCCCCCCC		25.7823403867
340PhosphorylationVFFSRGSSFRYSGRT
EEEECCCCCCCCCCC		19.3022617229
342MethylationFSRGSSFRYSGRTQK
EECCCCCCCCCCCHH		27.01-
343PhosphorylationSRGSSFRYSGRTQKQ
ECCCCCCCCCCCHHH		17.2923403867
344PhosphorylationRGSSFRYSGRTQKQL
CCCCCCCCCCCHHHH		19.9728355574
347PhosphorylationSFRYSGRTQKQLVDY
CCCCCCCCHHHHHHH		43.5828102081
349UbiquitinationRYSGRTQKQLVDYFK
CCCCCCHHHHHHHHH		45.01-
349UbiquitinationRYSGRTQKQLVDYFK
CCCCCCHHHHHHHHH		45.01-
354PhosphorylationTQKQLVDYFKDSGMK
CHHHHHHHHHHCCCC		12.6827642862
356UbiquitinationKQLVDYFKDSGMKRI
HHHHHHHHHCCCCCC		44.76-
356UbiquitinationKQLVDYFKDSGMKRI
HHHHHHHHHCCCCCC		44.76-
358PhosphorylationLVDYFKDSGMKRIPY
HHHHHHHCCCCCCCC		41.1825159151
365PhosphorylationSGMKRIPYERRHSKT
CCCCCCCCHHCCCCC		21.5022817900
370PhosphorylationIPYERRHSKTHTSVR
CCCHHCCCCCCCHHH		37.1233259812
375PhosphorylationRHSKTHTSVRALTAD
CCCCCCCHHHHHHCC		11.2925627689
380PhosphorylationHTSVRALTADLPKQS
CCHHHHHHCCCCCCC		19.6928348404
385UbiquitinationALTADLPKQSISFPE
HHHCCCCCCCCCCCC		65.072190698
385 (in isoform 2)Ubiquitination-65.0721906983
385 (in isoform 1)Ubiquitination-65.0721906983
385UbiquitinationALTADLPKQSISFPE
HHHCCCCCCCCCCCC		65.0721906983
387PhosphorylationTADLPKQSISFPEGL
HCCCCCCCCCCCCCC		26.7325106551
389PhosphorylationDLPKQSISFPEGLRT
CCCCCCCCCCCCCCC		39.7428348404
396PhosphorylationSFPEGLRTPASPSSA
CCCCCCCCCCCCCCC		28.4025850435
399PhosphorylationEGLRTPASPSSANAF
CCCCCCCCCCCCCCC		26.9021712546
401PhosphorylationLRTPASPSSANAFYS
CCCCCCCCCCCCCCC		39.3221712546
402PhosphorylationRTPASPSSANAFYSL
CCCCCCCCCCCCCCC		29.0021712546
407PhosphorylationPSSANAFYSLSPSTL
CCCCCCCCCCCHHHC		13.2921712546
408PhosphorylationSSANAFYSLSPSTLV
CCCCCCCCCCHHHCC		18.8725106551
410PhosphorylationANAFYSLSPSTLVPS
CCCCCCCCHHHCCCC		15.7426657352
412PhosphorylationAFYSLSPSTLVPSGL
CCCCCCHHHCCCCCC		30.8823186163
413PhosphorylationFYSLSPSTLVPSGLP
CCCCCHHHCCCCCCC		34.8521712546
425PhosphorylationGLPEFKDSSSSLTDP
CCCCCCCCCCCCCCC		32.4821945579
426PhosphorylationLPEFKDSSSSLTDPQ
CCCCCCCCCCCCCCC		33.8021945579
427PhosphorylationPEFKDSSSSLTDPQV
CCCCCCCCCCCCCCH		33.0621945579
428PhosphorylationEFKDSSSSLTDPQVS
CCCCCCCCCCCCCHH		36.9221945579
430PhosphorylationKDSSSSLTDPQVSYV
CCCCCCCCCCCHHEE		47.8121945579
435PhosphorylationSLTDPQVSYVKSPAA
CCCCCCHHEECCCHH		20.9721945579
436PhosphorylationLTDPQVSYVKSPAAE
CCCCCHHEECCCHHH		17.0321945579
438UbiquitinationDPQVSYVKSPAAERR
CCCHHEECCCHHHHC		42.3529967540
439PhosphorylationPQVSYVKSPAAERRS
CCHHEECCCHHHHCC		15.1029255136
446PhosphorylationSPAAERRSGAVAGGP
CCHHHHCCCCCCCCC		37.0127251789
455PhosphorylationAVAGGPDTPSAQPLG
CCCCCCCCCCCCCCC		23.4426657352
457PhosphorylationAGGPDTPSAQPLGPP
CCCCCCCCCCCCCCC		41.4523312004
473PhosphorylationLQPGPGLSTKSPQPS
CCCCCCCCCCCCCCC		39.4427251789
474PhosphorylationQPGPGLSTKSPQPSP
CCCCCCCCCCCCCCC		40.3523312004
476PhosphorylationGPGLSTKSPQPSPSS
CCCCCCCCCCCCCCC		28.9327422710
480PhosphorylationSTKSPQPSPSSRKSP
CCCCCCCCCCCCCCC		31.9727251789
482PhosphorylationKSPQPSPSSRKSPLS
CCCCCCCCCCCCCCC		47.3027251789
483PhosphorylationSPQPSPSSRKSPLSL
CCCCCCCCCCCCCCC		47.3025072903
537PhosphorylationRVPADEAYFIVKEIL
CCCHHHHHHHHHHHH		7.56-
574PhosphorylationKEDAMPATLMTLLFS
CCCCCCHHHHHHHHC		15.93-
577PhosphorylationAMPATLMTLLFSNID
CCCHHHHHHHHCCCH		24.34-
581PhosphorylationTLMTLLFSNIDPIYE
HHHHHHHCCCHHHHH		32.61-
645PhosphorylationQRHDEVLTELEKATK
HHHHHHHHHHHHHHH		43.64-
792PhosphorylationTSKGVAGTSHFRIRG
HCCCCCCCCCCEECC		14.8622468782
793PhosphorylationSKGVAGTSHFRIRGL
CCCCCCCCCCEECCE		21.5122468782
835PhosphorylationKTIVVAASTRLEKEK
EEEEEEECCCHHHHH		12.3429449344
836PhosphorylationTIVVAASTRLEKEKW
EEEEEECCCHHHHHH		34.2527251789
868PhosphorylationAPALPGRTVCTRPPR
CCCCCCCEEECCCCC		26.3328348404
871PhosphorylationLPGRTVCTRPPRSPN
CCCCEEECCCCCCCC		41.7026657352
876PhosphorylationVCTRPPRSPNEVSLE
EECCCCCCCCCCCCC		37.5423927012
881PhosphorylationPRSPNEVSLEQESED
CCCCCCCCCCCCCCC		21.7323927012
886PhosphorylationEVSLEQESEDDARGV
CCCCCCCCCCCHHHH		46.1223927012
895PhosphorylationDDARGVRSSLEGHGQ
CCHHHHHHHHCCCCC		36.5524719451
896PhosphorylationDARGVRSSLEGHGQH
CHHHHHHHHCCCCCC		21.6327251275
907PhosphorylationHGQHRANTTMHVCWY
CCCCCCCCEEEEEEE		25.22-
908PhosphorylationGQHRANTTMHVCWYR
CCCCCCCEEEEEEEC		12.70-
914PhosphorylationTTMHVCWYRNTSVSR
CEEEEEEECCCCCCC		6.72-
981PhosphorylationPLLGYSVSIPREADG
CCCCEEEECCCCCCC		22.4224719451
1033PhosphorylationSSAGRAPSIVQDGPQ
CCCCCCCCHHCCCCC		34.1128857561
1042PhosphorylationVQDGPQPSSGLEGMV
HCCCCCCCCCCCCCC		31.6130624053
1043PhosphorylationQDGPQPSSGLEGMVR
CCCCCCCCCCCCCCC		54.8230624053
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FARP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FARP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FARP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UB2G2_HUMANUBE2G2physical
21988832
RS27A_HUMANRPS27Aphysical
28514442
TRI41_HUMANTRIM41physical
28514442
ICLN_HUMANCLNS1Aphysical
28514442
ANM5_HUMANPRMT5physical
28514442
RIOK1_HUMANRIOK1physical
28514442
COPRS_HUMANCOPRSphysical
28514442
KPCI_HUMANPRKCIphysical
28514442
GRDN_HUMANCCDC88Aphysical
28514442
NCBP3_HUMANC17orf85physical
28514442
HERC2_HUMANHERC2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FARP2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428; THR-430 ANDSER-886, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.

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