GRID1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRID1_HUMAN
• UniProt AC: Q9ULK0
• Protein Name: Glutamate receptor ionotropic, delta-1
• Gene Name: GRID1
• Organism: Homo sapiens (Human).
• Sequence Length: 1009
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists..
• Protein Sequence: MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	QSEKITYSIKVIEAN HCCCEEEEEEEEECC	13.79	24719451
131	N-linked_Glycosylation	PRTACHLNPSPDGEA CCCEEECCCCCCCCC	16.02	-
200	N-linked_Glycosylation	SLQKVDKNISHVFTS CHHHCCCCHHHHHHH	36.21	UniProtKB CARBOHYD
207	Phosphorylation	NISHVFTSLFTTMKT CHHHHHHHHHHHCCH	15.26	25627689
364	Phosphorylation	KPWNGGRSMLDTIKK CCCCCCHHHHHHHHH	27.29	-
368	Phosphorylation	GGRSMLDTIKKGHIT CCHHHHHHHHHCCCC	30.63	-
375	Phosphorylation	TIKKGHITGLTGVME HHHHCCCCCEEEEEE	22.06	22210691
388	Phosphorylation	MEFREDSSNPYVQFE EEEECCCCCCEEEEE	54.89	30576142
399	Phosphorylation	VQFEILGTTYSETFG EEEEEECEEHHHHHC	21.08	30576142
422	N-linked_Glycosylation	WDSEKGLNGSLQERP CCCCCCCCCCCCCCC	46.83	UniProtKB CARBOHYD
498	N-linked_Glycosylation	RYGHQLHNTSWNGMI CCCCCCCCCCCCHHH	44.38	UniProtKB CARBOHYD
536	Phosphorylation	VVDFSKRYMDYSVGI HCCHHHHHCCEEEEE	9.70	23403867
539	Phosphorylation	FSKRYMDYSVGILIK HHHHHCCEEEEEEEC	6.69	23403867
540	Phosphorylation	SKRYMDYSVGILIKK HHHHCCEEEEEEECC	15.03	23403867
667	Phosphorylation	RMDNPIRTFQDLSKQ CCCCCCHHHHHHHHH	26.77	-
678	Phosphorylation	LSKQVEMSYGTVRDS HHHHHHHHHCCCCHH	13.60	26471730
679	Phosphorylation	SKQVEMSYGTVRDSA HHHHHHHHCCCCHHH	18.59	26471730
681	Phosphorylation	QVEMSYGTVRDSAVY HHHHHHCCCCHHHHH	12.25	26471730
685	Phosphorylation	SYGTVRDSAVYEYFR HHCCCCHHHHHHHHH	14.74	22985185
688	Phosphorylation	TVRDSAVYEYFRAKG CCCHHHHHHHHHHCC	12.48	22985185
690	Phosphorylation	RDSAVYEYFRAKGTN CHHHHHHHHHHCCCC	4.81	22985185
780	Phosphorylation	ALQHGSPYRDLFSQR ECCCCCCCHHHHHHH	20.61	-
864	Phosphorylation	SNRCHQETPKEDKEV CCCCCCCCCCCCCCC	32.84	18452278
882	Phosphorylation	QVHRRMNSLMDEDIA HHHHHHHHHCCHHHH	18.74	28450419
920	Phosphorylation	TLEPTREYQNTQLSV CCCCCCCCCCCEEEE	12.08	27642862
1003	Phosphorylation	VLPEALDTSHGTSI- CCCHHHCCCCCCCC-	24.39	28450419
1004	Phosphorylation	LPEALDTSHGTSI-- CCHHHCCCCCCCC--	21.42	28450419
1007	Phosphorylation	ALDTSHGTSI----- HHCCCCCCCC-----	20.16	28450419
1008	Phosphorylation	LDTSHGTSI------ HCCCCCCCC------	30.78	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRID1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRID1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRID1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HBB_HUMAN	HBB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.