ALG12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG12_HUMAN
• UniProt AC: Q9BV10
• Protein Name: Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
• Gene Name: ALG12
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation..
• Protein Sequence: MAGKGSSGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHEWARFIWLSAFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHAPTVLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSATALYVSHFNYPGGVAMQRLHQLVPPQTDVLLHIDVAAAQTGVSRFLQVNSAWRYDKREDVQPGTGMLAYTHILMEAAPGLLALYRDTHRVLASVVGTTGVSLNLTQLPPFNVHLQTKLVLLERLPRPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
205	Phosphorylation	ALGNRKVSVVRALRH HHCCCCHHHHHHHHH	20.24	24719451
241	Ubiquitination	QLTWPEGKVLWYNTV HCCCCCCCEEEEEEE	32.28	-
266	Phosphorylation	PLLWYFYSALPRGLG CHHHHHHHHCCCCCC	17.27	24719451
288	Phosphorylation	LGLVDRRTHAPTVLA CCCCCCCCCHHHHHH	24.23	46162239
292	Phosphorylation	DRRTHAPTVLALGFM CCCCCHHHHHHHHHH	29.00	46162245
336	Ubiquitination	SYLLNNYKKSWLYKA HHHHHHCCHHHHHHH	42.32	-
403	Phosphorylation	AAAQTGVSRFLQVNS HHHHHCHHHHHEECC	20.75	46162227
410	Phosphorylation	SRFLQVNSAWRYDKR HHHHEECCCCCCCCC	30.28	46162233
414	Phosphorylation	QVNSAWRYDKREDVQ EECCCCCCCCCCCCC	18.34	46162251

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX4_HUMAN	PRDX4	physical	21988832
RL13A_HUMAN	RPL13A	physical	21988832
NUP53_HUMAN	NUP35	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.