IPRI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPRI_HUMAN
• UniProt AC: Q8IWB1
• Protein Name: Inositol 1,4,5-trisphosphate receptor-interacting protein
• Gene Name: ITPRIP
• Organism: Homo sapiens (Human).
• Sequence Length: 547
• Subcellular Localization: Cell membrane .
• Protein Description: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release..
• Protein Sequence: MAMGLFRVCLVVVTAIINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	N-linked_Glycosylation	PLLFPRENATVPENE CCCCCCCCCCCCCCH	42.04	UniProtKB CARBOHYD
47	Ubiquitination	KMQAHQEKLQLEQLR HHHHHHHHHHHHHHH	34.66	29967540
66	Ubiquitination	VARLAAEKEALEQVA HHHHHHHHHHHHHHH	43.49	21963094
66	2-Hydroxyisobutyrylation	VARLAAEKEALEQVA HHHHHHHHHHHHHHH	43.49	-
71	Ubiquitination	AEKEALEQVAEEGRQ HHHHHHHHHHHHHHH	40.34	21963094
80	N-linked_Glycosylation	AEEGRQQNETRVAWD HHHHHHHCHHHHHHH	44.24	UniProtKB CARBOHYD
141	Phosphorylation	LTLPNKATLGHFYER CCCCCCCCHHHHHHH	34.58	-
244	Ubiquitination	RQGYGQIKVVRADGD CCCCCEEEEEECCCC	27.13	-
252	Phosphorylation	VVRADGDTLSCICGK EEECCCCEEEEECCC	26.54	21712546
259	Ubiquitination	TLSCICGKTKLGEDM EEEEECCCCCCCCCE	37.77	21963094
260	Phosphorylation	LSCICGKTKLGEDML EEEECCCCCCCCCEE	19.45	24532841
261	Ubiquitination	SCICGKTKLGEDMLC EEECCCCCCCCCEEH	58.96	21963094
264	Ubiquitination	CGKTKLGEDMLCLLH CCCCCCCCCEEHHHH	51.16	21963094
266	Ubiquitination	KTKLGEDMLCLLHGR CCCCCCCEEHHHHCC	2.18	21963094
335	Ubiquitination	LDSPGSLKIKFRSGK CCCCCCEEEEECCCC	45.61	21963094
340	Ubiquitination	SLKIKFRSGKFMPFN CEEEEECCCCCCCCC	49.85	21963094
397	Ubiquitination	HFLRTTLKALPEGAC HHHHHHHHHCCCCCH	45.87	21963094
402	Ubiquitination	TLKALPEGACHLSCL HHHHCCCCCHHHHHH	31.40	21963094
407	Phosphorylation	PEGACHLSCLQIASF CCCCHHHHHHHHHHH	6.79	-
417	Phosphorylation	QIASFLLSKQSRLTG HHHHHHHHCCCCCCC	30.69	-
429	Phosphorylation	LTGPSGLSSYHLKTA CCCCCCCCHHHHHHH	32.17	24719451
434	Ubiquitination	GLSSYHLKTALLHLL CCCHHHHHHHHHHHH	20.59	23503661
439	Ubiquitination	HLKTALLHLLLLRQA HHHHHHHHHHHHHHH	18.45	23503661
450	Ubiquitination	LRQAADWKAGQLDAR HHHHCCHHCCHHHHH	43.09	21963094
455	Ubiquitination	DWKAGQLDARLHELL CHHCCHHHHHHHHHH	23.04	21963094
467	Ubiquitination	ELLCFLEKSLLQKKL HHHHHHHHHHHHHHC	48.85	21963094
472	Ubiquitination	LEKSLLQKKLHHFFI HHHHHHHHHCCHHHC	58.22	21963094
473	Ubiquitination	EKSLLQKKLHHFFIG HHHHHHHHCCHHHCC	39.84	29967540
515	Ubiquitination	LQRSLYRKTLDSFYE HCHHHHHHHHHHHHH	39.62	-
525	Ubiquitination	DSFYEMLKNAPALIS HHHHHHHHCCCHHHH	50.15	29967540
534	Phosphorylation	APALISEYSLHVPSD CCHHHHEEEECCCCC	15.11	27642862
540	Phosphorylation	EYSLHVPSDQPTPKS EEEECCCCCCCCCCC	48.03	21712546
544	Phosphorylation	HVPSDQPTPKS---- CCCCCCCCCCC----	37.40	25159151
546	Ubiquitination	PSDQPTPKS------ CCCCCCCCC------	71.87	21963094
547	Phosphorylation	SDQPTPKS------- CCCCCCCC-------	46.81	25159151
551	Ubiquitination	TPKS----------- CCCC-----------		21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPRI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPRI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPRI_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IPRI_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547, AND MASSSPECTROMETRY.
PubMed: 18669648