| UniProt ID | SGCB_HUMAN | |
|---|---|---|
| UniProt AC | Q16585 | |
| Protein Name | Beta-sarcoglycan | |
| Gene Name | SGCB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 318 | |
| Subcellular Localization |
Cell membrane, sarcolemma Single-pass type II membrane protein. Cytoplasm, cytoskeleton. |
|
| Protein Description | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.. | |
| Protein Sequence | MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | AAAAEQQSSNGPVKK HHHHHHHHCCCCCCH | 26.01 | 28857561 | |
| 21 | Phosphorylation | SNGPVKKSMREKAVE CCCCCCHHHHHHHHH | 19.84 | 24275569 | |
| 31 | Phosphorylation | EKAVERRSVNKEHNS HHHHHHHCCCHHCCC | 35.94 | 29514088 | |
| 34 | Ubiquitination | VERRSVNKEHNSNFK HHHHCCCHHCCCCCC | 59.19 | - | |
| 41 | Ubiquitination | KEHNSNFKAGYIPID HHCCCCCCCEEEECC | 45.19 | 21906983 | |
| 41 | Malonylation | KEHNSNFKAGYIPID HHCCCCCCCEEEECC | 45.19 | 26320211 | |
| 41 | Ubiquitination | KEHNSNFKAGYIPID HHCCCCCCCEEEECC | 45.19 | - | |
| 44 | Phosphorylation | NSNFKAGYIPIDEDR CCCCCCEEEECCHHH | 14.37 | 25884760 | |
| 54 | Ubiquitination | IDEDRLHKTGLRGRK CCHHHHHHCCCCCCC | 49.21 | - | |
| 82 | Ubiquitination | LAVINLIITLVIWAV HHHHHHHHHHHHHHH | 2.48 | - | |
| 111 | Ubiquitination | ESGLLRFKQVSDMGV HHCCEEEEEECCCCC | 43.27 | 21906983 | |
| 123 | Phosphorylation | MGVIHPLYKSTVGGR CCCEEEEEECCCCCC | 13.82 | 29116813 | |
| 124 | Ubiquitination | GVIHPLYKSTVGGRR CCEEEEEECCCCCCC | 47.54 | 21906983 | |
| 126 | Ubiquitination | IHPLYKSTVGGRRNE EEEEEECCCCCCCCC | 21.01 | - | |
| 132 | Ubiquitination | STVGGRRNENLVITG CCCCCCCCCCEEEEC | 40.94 | - | |
| 149 | Ubiquitination | QPIVFQQGTTKLSVE CCEEEECCCEEEEEE | 25.27 | - | |
| 152 | Ubiquitination | VFQQGTTKLSVENNK EEECCCEEEEEECCC | 38.31 | 21906983 | |
| 158 | N-linked_Glycosylation | TKLSVENNKTSITSD EEEEEECCCCEEEEE | 35.16 | 19159218 | |
| 196 | Ubiquitination | FHLPSGVKSLNVQKA EECCCCCEEECCCCC | 53.39 | 21906983 | |
| 202 | Ubiquitination | VKSLNVQKASTERIT CEEECCCCCCCCEEC | 39.77 | 21906983 | |
| 211 | N-linked_Glycosylation | STERITSNATSDLNI CCCEECCCCCCCCEE | 38.29 | 19159218 | |
| 216 | Ubiquitination | TSNATSDLNIKVDGR CCCCCCCCEEEECCE | 7.76 | - | |
| 219 | Ubiquitination | ATSDLNIKVDGRAIV CCCCCEEEECCEEEE | 32.95 | 21906983 | |
| 258 | N-linked_Glycosylation | AENSIILNGSVMVST EECEEEECCEEEEEE | 30.22 | UniProtKB CARBOHYD | |
| 264 | Phosphorylation | LNGSVMVSTTRLPSS ECCEEEEEECCCCCC | 13.13 | 27732954 | |
| 265 | Phosphorylation | NGSVMVSTTRLPSSS CCEEEEEECCCCCCC | 12.43 | 27732954 | |
| 266 | Phosphorylation | GSVMVSTTRLPSSSS CEEEEEECCCCCCCC | 23.78 | 27732954 | |
| 286 | Ubiquitination | SGDWVRYKLCMCADG CCCCEEEEEEEECCC | 25.33 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SGCB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SGCB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SGCB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SGCB_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00565 | Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystr | |||||
| H00593 | Limb-girdle muscular dystrophy (LGMD) | |||||
| OMIM Disease | ||||||
| 604286 | Limb-girdle muscular dystrophy 2E (LGMD2E) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-158 AND ASN-211, AND MASSSPECTROMETRY. | |
