CSTN3_HUMAN - dbPTM
CSTN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSTN3_HUMAN
UniProt AC Q9BQT9
Protein Name Calsyntenin-3
Gene Name CLSTN3
Organism Homo sapiens (Human).
Sequence Length 956
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Endoplasmic reticulum membrane. Golgi apparatus membrane. Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization..
Protein Description May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation..
Protein Sequence MTLLLLPLLLASLLASCSCNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGKKEEETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEEKNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSISHQVEAKKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLELTNTSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAATLIIVVCVGFLVLMVVLGLVRIHSLHRRVSGAGGPPGASSDPKDPDLFWDDSALTIIVNPMESYQNRQSCVTGAVGGQQEDEDSSDSEVADSPSSDERRIIETPPHRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTLLLLPLL
------CCHHHHHHH		26.5524043423
12PhosphorylationLLPLLLASLLASCSC
HHHHHHHHHHHHCCC		24.7224043423
16PhosphorylationLLASLLASCSCNKAN
HHHHHHHHCCCCCHH		13.4124043423
18PhosphorylationASLLASCSCNKANKH
HHHHHHCCCCCHHCC		20.4524043423
160PhosphorylationAVTEGKLYDRILRVE
HHHCCCCCCEEEEEE		13.4819835603
187O-linked_GlycosylationICYYEILTPNTPFLI
EEEEEECCCCCCEEE		21.83OGP
283O-linked_GlycosylationPLWNIQATIELQTSH
CCCCCEEEEEEEHHH		9.90OGP
299N-linked_GlycosylationAKGCDRDNYSERALR
HCCCCCCCCCHHHHH		43.02UniProtKB CARBOHYD
327N-linked_GlycosylationPMPGPNANWTAGLSV
CCCCCCCCCCCEEEE		43.18UniProtKB CARBOHYD
347N-linked_GlycosylationSSLIYWFNGTQAVQV
CCEEEEECCCEEEEE		38.16UniProtKB CARBOHYD
411PhosphorylationEDGFSHYSLTVHGCR
CCCCCEEEEEEECCC		16.4922210691
413PhosphorylationGFSHYSLTVHGCRIA
CCCEEEEEEECCCEE		12.4322210691
429PhosphorylationLYWPLLESARPVKFL
EHHHHHHHCCCHHHH		29.5522210691
507N-linked_GlycosylationKEKEKGDNSTDTTQG
CCCCCCCCCCCCCCC		56.32UniProtKB CARBOHYD
509PhosphorylationKEKGDNSTDTTQGDP
CCCCCCCCCCCCCCC		43.5528348404
511PhosphorylationKGDNSTDTTQGDPLS
CCCCCCCCCCCCCCE		22.5528348404
512PhosphorylationGDNSTDTTQGDPLSI
CCCCCCCCCCCCCEE		33.1128348404
563UbiquitinationRDFESLGKGMKVHVN
CCHHHHCCCCEEEEC		62.21-
575 (in isoform 2)Ubiquitination-3.08-
687PhosphorylationVEAKKDESWQGTVTD
EEECCCCCCCCEECC		34.5321712546
691PhosphorylationKDESWQGTVTDTRMS
CCCCCCCEECCCCCC		12.72-
691O-linked_GlycosylationKDESWQGTVTDTRMS
CCCCCCCEECCCCCC		12.7255828115
693PhosphorylationESWQGTVTDTRMSDE
CCCCCEECCCCCCHH		31.33-
693O-linked_GlycosylationESWQGTVTDTRMSDE
CCCCCEECCCCCCHH		31.3355828121
740N-linked_GlycosylationQRGLELTNTSAYLTI
HHCCCCCCCCEEEEE		44.66UniProtKB CARBOHYD
741PhosphorylationRGLELTNTSAYLTIA
HCCCCCCCCEEEEEC		14.9722210691
744PhosphorylationELTNTSAYLTIAGVE
CCCCCCEEEEECCCC		12.2622210691
746PhosphorylationTNTSAYLTIAGVESI
CCCCEEEEECCCCEE		8.9822210691
774PhosphorylationLRHGAALYTRKFRLS
HHHCCEEEEEEEEEE		10.3629083192
775PhosphorylationRHGAALYTRKFRLSC
HHCCEEEEEEEEEEH		28.3829083192
816O-linked_GlycosylationHPSHVLSSQQFLHRG
CHHHHHCCHHHHHCC		24.68OGP
878PhosphorylationHSLHRRVSGAGGPPG
HHHHHHHCCCCCCCC		22.55-
887PhosphorylationAGGPPGASSDPKDPD
CCCCCCCCCCCCCCC		40.9823532336
888PhosphorylationGGPPGASSDPKDPDL
CCCCCCCCCCCCCCC		58.3523532336
932PhosphorylationGQQEDEDSSDSEVAD
CCCCCCCCCCCCCCC		33.7228348404
933PhosphorylationQQEDEDSSDSEVADS
CCCCCCCCCCCCCCC		58.4333259812
935PhosphorylationEDEDSSDSEVADSPS
CCCCCCCCCCCCCCC		35.6028348404
951PhosphorylationDERRIIETPPHRY--
CCCCCCCCCCCCC--		31.54-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CSTN3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSTN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSTN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CSTN3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSTN3_HUMAN

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Related Literatures of Post-Translational Modification

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