DMB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMB_HUMAN
• UniProt AC: P28068
• Protein Name: HLA class II histocompatibility antigen, DM beta chain
• Gene Name: HLA-DMB
• Organism: Homo sapiens (Human).
• Sequence Length: 263
• Subcellular Localization: Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Localizes to late endocytic compartment. Associates with lysosome membranes.
• Protein Description: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO..
• Protein Sequence: MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHIGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	N-linked_Glycosylation	PFWGSLTNRTRPPSV CCCHHCCCCCCCCCE	48.93	16335952
216	Phosphorylation	PGLSPMQTLKVSVSA CCCCHHHCEEEHHHH	23.46	-
239	Phosphorylation	IFSLGVISWRRAGHS HHHHCEEEHHCCCCC	16.48	24719451
246	Phosphorylation	SWRRAGHSSYTPLPG EHHCCCCCCCCCCCC	24.91	27080861
247	Phosphorylation	WRRAGHSSYTPLPGS HHCCCCCCCCCCCCC	27.61	27080861
248	Phosphorylation	RRAGHSSYTPLPGSN HCCCCCCCCCCCCCC	18.52	30108239
249	Phosphorylation	RAGHSSYTPLPGSNY CCCCCCCCCCCCCCC	21.94	27080861
254	Phosphorylation	SYTPLPGSNYSEGWH CCCCCCCCCCCCCCC	30.56	27080861
256	Phosphorylation	TPLPGSNYSEGWHIS CCCCCCCCCCCCCCC	15.14	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DMB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	21988832
TEAD1_HUMAN	TEAD1	physical	21988832
DHRS7_HUMAN	DHRS7	physical	26186194
AP3M1_HUMAN	AP3M1	physical	26186194
PHOP1_HUMAN	PHOSPHO1	physical	26186194
AP3M1_HUMAN	AP3M1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, AND MASSSPECTROMETRY.
PubMed: 16335952