| UniProt ID | PHOP1_HUMAN | |
|---|---|---|
| UniProt AC | Q8TCT1 | |
| Protein Name | Phosphoethanolamine/phosphocholine phosphatase | |
| Gene Name | PHOSPHO1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 267 | |
| Subcellular Localization | ||
| Protein Description | Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.. | |
| Protein Sequence | MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSGCFPVSG ------CCCCCCCCC | 44.24 | 30576142 | |
| 8 | Phosphorylation | MSGCFPVSGLRCLSR CCCCCCCCCCEEECC | 32.14 | 30576142 | |
| 14 | Phosphorylation | VSGLRCLSRDGRMAA CCCCEEECCCCCCHH | 31.77 | 30576142 | |
| 27 (in isoform 2) | Phosphorylation | - | 6.80 | 30631047 | |
| 28 (in isoform 2) | Phosphorylation | - | 4.68 | 30631047 | |
| 29 (in isoform 3) | Phosphorylation | - | 4.05 | 30631047 | |
| 30 (in isoform 3) | Phosphorylation | - | 24.25 | 30631047 | |
| 33 (in isoform 2) | Phosphorylation | - | 8.81 | 30631047 | |
| 35 (in isoform 3) | Phosphorylation | - | 40.19 | 30631047 | |
| 37 (in isoform 2) | Phosphorylation | - | 3.28 | 30631047 | |
| 39 (in isoform 3) | Phosphorylation | - | 45.57 | 30631047 | |
| 182 | Phosphorylation | MCKHKVLSDYLRERA HHHHHHHHHHHHHHH | 27.48 | 28152594 | |
| 184 | Phosphorylation | KHKVLSDYLRERAHD HHHHHHHHHHHHHCC | 12.32 | 23186163 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PHOP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PHOP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PHOP1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ACY1_HUMAN | ACY1 | physical | 26186194 | |
| CTF18_HUMAN | CHTF18 | physical | 26186194 | |
| CTF18_HUMAN | CHTF18 | physical | 28514442 | |
| ACY1_HUMAN | ACY1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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