dbPTM

TSPO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TSPO_HUMAN
UniProt AC	P30536
Protein Name	Translocator protein
Gene Name	TSPO
Organism	Homo sapiens (Human).
Sequence Length	169
Subcellular Localization	Mitochondrion membrane Multi-pass membrane protein .
Protein Description	Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism. [PubMed: 24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides]
Protein Sequence	MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
12	Phosphorylation	WVPAMGFTLAPSLGC CCCCCCCEECHHCCE	20068231
16	Phosphorylation	MGFTLAPSLGCFVGS CCCEECHHCCEEECC	20068231
23	Phosphorylation	SLGCFVGSRFVHGEG HCCEEECCEEECCCC	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TSPO_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TSPO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TSPO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CR3L1_HUMAN	CREB3L1	physical	25416956
ARF4_HUMAN	ARF4	physical	26344197
AT5F1_HUMAN	ATP5F1	physical	26344197
CISD1_HUMAN	CISD1	physical	26344197
RABP1_HUMAN	CRABP1	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TSPO_HUMAN

Related Literatures of Post-Translational Modification