KLF13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF13_HUMAN
• UniProt AC: Q9Y2Y9
• Protein Name: Krueppel-like factor 13
• Gene Name: KLF13
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Nucleus.
• Protein Description: Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells..
• Protein Sequence: MAAAAYVDHFAAECLVSMSSRAVVHGPREGPESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPPAPEPTSPGAEGAAAAPPSPAWSEPEPEAGLEPEREPGPAGSGEPGLRQRVRRGRSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQDCNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAAAYVDHFAAE --CCHHHHHHHHHHH	11.15	27642862
43	Phosphorylation	EGAAVAATPTLPRVE CCCEEEECCCCCCHH	13.68	23312004
45	Phosphorylation	AAVAATPTLPRVEER CEEEECCCCCCHHHH	45.07	23312004
56	Ubiquitination	VEERRDGKDSASLFV HHHHCCCCCHHHHHH	53.45	-
58	Phosphorylation	ERRDGKDSASLFVVA HHCCCCCHHHHHHHH	24.20	28555341
60	Phosphorylation	RDGKDSASLFVVARI CCCCCHHHHHHHHHH	26.71	-
107	Phosphorylation	PPAPEPTSPGAEGAA CCCCCCCCCCCCCCC	31.86	25921289
119	Phosphorylation	GAAAAPPSPAWSEPE CCCCCCCCCCCCCCC	26.62	25921289
123	Phosphorylation	APPSPAWSEPEPEAG CCCCCCCCCCCCCCC	45.43	25921289
142	Phosphorylation	REPGPAGSGEPGLRQ CCCCCCCCCCHHHHH	41.93	21815630
156	Phosphorylation	QRVRRGRSRADLESP HHHHHCCCHHHCCCH	34.34	23403867
162	Phosphorylation	RSRADLESPQRKHKC CCHHHCCCHHHHCCC	33.36	23401153
166	Acetylation	DLESPQRKHKCHYAG HCCCHHHHCCCCCCC	42.01	12758070
168	Ubiquitination	ESPQRKHKCHYAGCE CCHHHHCCCCCCCCH	26.24	11748222
168	Acetylation	ESPQRKHKCHYAGCE CCHHHHCCCCCCCCH	26.24	12758070
176	Ubiquitination	CHYAGCEKVYGKSSH CCCCCCHHHCCCCHH	44.85	11748222
176	Acetylation	CHYAGCEKVYGKSSH CCCCCCHHHCCCCHH	44.85	11748222
180	Ubiquitination	GCEKVYGKSSHLKAH CCHHHCCCCHHHHHH	30.97	11748222
180	Acetylation	GCEKVYGKSSHLKAH CCHHHCCCCHHHHHH	30.97	12758070
185	Ubiquitination	YGKSSHLKAHLRTHT CCCCHHHHHHHHHCC	28.47	11748222
185	Sumoylation	YGKSSHLKAHLRTHT CCCCHHHHHHHHHCC	28.47	-
185	Sumoylation	YGKSSHLKAHLRTHT CCCCHHHHHHHHHCC	28.47	11748222
185	Acetylation	YGKSSHLKAHLRTHT CCCCHHHHHHHHHCC	28.47	11748222
192	Phosphorylation	KAHLRTHTGERPFAC HHHHHHCCCCCCCCE	39.87	25159151
206	Ubiquitination	CSWQDCNKKFARSDE EEHHHHCHHHHCHHH	56.45	11748222
206	Acetylation	CSWQDCNKKFARSDE EEHHHHCHHHHCHHH	56.45	11748222
207	Ubiquitination	SWQDCNKKFARSDEL EHHHHCHHHHCHHHH	30.20	-
207	Acetylation	SWQDCNKKFARSDEL EHHHHCHHHHCHHHH	30.20	11748222
220	Phosphorylation	ELARHYRTHTGEKKF HHHHHHHHCCCCCCC	19.34	-
222	Phosphorylation	ARHYRTHTGEKKFSC HHHHHHCCCCCCCCC	46.56	-
225	Acetylation	YRTHTGEKKFSCPIC HHHCCCCCCCCCCCH	61.54	12758070
225	Ubiquitination	YRTHTGEKKFSCPIC HHHCCCCCCCCCCCH	61.54	11748222
226	Acetylation	RTHTGEKKFSCPICE HHCCCCCCCCCCCHH	37.90	12758070
226	Ubiquitination	RTHTGEKKFSCPICE HHCCCCCCCCCCCHH	37.90	11748222
234	Acetylation	FSCPICEKRFMRSDH CCCCCHHHHHHCCHH	46.66	11748222
234	Ubiquitination	FSCPICEKRFMRSDH CCCCCHHHHHHCCHH	46.66	11748222
239	Phosphorylation	CEKRFMRSDHLTKHA HHHHHHCCHHHHHHH	20.00	26074081
243	Phosphorylation	FMRSDHLTKHARRHA HHCCHHHHHHHHHHH	19.84	26074081
244	Acetylation	MRSDHLTKHARRHAN HCCHHHHHHHHHHHC	41.44	11748222
244	Ubiquitination	MRSDHLTKHARRHAN HCCHHHHHHHHHHHC	41.44	11748222
264	Phosphorylation	LQRRGGGSRTGSLSD HCCCCCCCCCCCHHH	29.91	29449344
266	Phosphorylation	RRGGGSRTGSLSDYS CCCCCCCCCCHHHCC	32.59	30108239
268	Phosphorylation	GGGSRTGSLSDYSRS CCCCCCCCHHHCCCC	24.88	23401153
270	Phosphorylation	GSRTGSLSDYSRSDA CCCCCCHHHCCCCCC	35.88	21815630
272	Phosphorylation	RTGSLSDYSRSDASS CCCCHHHCCCCCCCC	11.56	27251275
273	Phosphorylation	TGSLSDYSRSDASSP CCCHHHCCCCCCCCC	30.23	30108239
275	Phosphorylation	SLSDYSRSDASSPTI CHHHCCCCCCCCCCC	31.43	23663014
278	Phosphorylation	DYSRSDASSPTISPA HCCCCCCCCCCCCCC	41.67	23663014
279	Phosphorylation	YSRSDASSPTISPAS CCCCCCCCCCCCCCC	27.99	22115753
281	Phosphorylation	RSDASSPTISPASSP CCCCCCCCCCCCCCC	35.71	23663014
283	Phosphorylation	DASSPTISPASSP-- CCCCCCCCCCCCC--	19.52	22617229
286	Phosphorylation	SPTISPASSP----- CCCCCCCCCC-----	46.67	23663014
287	Phosphorylation	PTISPASSP------ CCCCCCCCC------	36.41	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	11438660
CBP_HUMAN	CREBBP	genetic	11748222
CBP_HUMAN	CREBBP	physical	11748222
SERPH_HUMAN	SERPINH1	physical	11748222
KAT2B_HUMAN	KAT2B	physical	11748222
SRBP1_HUMAN	SREBF1	physical	16303770
SRBP2_HUMAN	SREBF2	physical	16303770

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.