CCD80_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD80_HUMAN
• UniProt AC: Q76M96
• Protein Name: Coiled-coil domain-containing protein 80
• Gene Name: CCDC80
• Organism: Homo sapiens (Human).
• Sequence Length: 950
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Promotes cell adhesion and matrix assembly..
• Protein Sequence: MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPDSSRPARFLRHTGRSRGIERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGAAVRPEQRPAARGSPREMIRDEGSSARSRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGVEGQVVAEGNDGGGGAGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPGRFRDNRMDRREHGHRDPNVVPGPPKPAKEKPPKKKAQDKILSNEYEEKYDLSRPTASQLEDELQVGNVPLKKAKESKKHEKLEKPEKEKKKKMKNENADKLLKSEKQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPTNKHFTQSPKKSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIKDMEKQKKEGIVCKEDKKQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	O-linked_Glycosylation	RSRGIERSTLEEPNL CCCCCCCCCCCCCCC	25.26	55829357
65	O-linked_Glycosylation	SRGIERSTLEEPNLQ CCCCCCCCCCCCCCH	44.39	55829363
79	Phosphorylation	QPLQRRRSVPVLRLA HHHHHCCCCCEEEEC	29.03	24719451
89	O-linked_Glycosylation	VLRLARPTEPPARSD EEEECCCCCCCCCCC	56.42	55833143
134	Phosphorylation	SRMLRFPSGSSSPNI HHHHCCCCCCCCCCE	48.90	22210691
136	Phosphorylation	MLRFPSGSSSPNILA HHCCCCCCCCCCEEH	31.79	22210691
137	Phosphorylation	LRFPSGSSSPNILAS HCCCCCCCCCCEEHH	54.03	28348404
138	Phosphorylation	RFPSGSSSPNILASF CCCCCCCCCCEEHHH	24.54	28348404
144	Phosphorylation	SSPNILASFAGKNRV CCCCEEHHHCCCCEE	16.51	22210691
169	Phosphorylation	GYYRLMMSLLKDDVY HHHHHHHHHHCCCHH	19.31	24719451
224	Phosphorylation	SLIPKLMSFLKLEKG HHHHHHHHHHHHCCC	37.55	24719451
232	Acetylation	FLKLEKGKFGMVLLK HHHHCCCCEEEEEEE	50.22	90607
305	Phosphorylation	GGGAGRPSLGSEKKK CCCCCCCCCCCCCCC	43.96	27251275
308	Phosphorylation	AGRPSLGSEKKKEDP CCCCCCCCCCCCCCC	52.08	27251275
323	O-linked_Glycosylation	RRAQVPPTRESRVKV CCCCCCCCHHHHHHH	40.78	55828157
329	Acetylation	PTRESRVKVLRKLAA CCHHHHHHHHHHHHH	34.15	7695351
347	Phosphorylation	ALPQPPSTPRATTLP CCCCCCCCCCCCCCC	23.67	-
351	Phosphorylation	PPSTPRATTLPPAPA CCCCCCCCCCCCCCC	30.09	-
352	Phosphorylation	PSTPRATTLPPAPAT CCCCCCCCCCCCCCC	35.96	-
359	Phosphorylation	TLPPAPATTVTRSTS CCCCCCCCEECCCCC	22.27	-
360	Phosphorylation	LPPAPATTVTRSTSR CCCCCCCEECCCCCC	23.22	-
366	Phosphorylation	TTVTRSTSRAVTVAA CEECCCCCCCEEEEE	21.35	-
370	Phosphorylation	RSTSRAVTVAARPMT CCCCCCEEEEECCCC	11.93	24043423
377	Phosphorylation	TVAARPMTTTAFPTT EEEECCCCCCCCCCC	24.55	24043423
378	Phosphorylation	VAARPMTTTAFPTTQ EEECCCCCCCCCCCC	15.18	24043423
379	Phosphorylation	AARPMTTTAFPTTQR EECCCCCCCCCCCCC	19.69	24043423
383	Phosphorylation	MTTTAFPTTQRPWTP CCCCCCCCCCCCCCC	29.16	24043423
384	Phosphorylation	TTTAFPTTQRPWTPS CCCCCCCCCCCCCCC	23.87	24043423
409	O-linked_Glycosylation	VITARRPSVSENLYP EEEECCCCCCCCCCC	36.14	46142629
409	Phosphorylation	VITARRPSVSENLYP EEEECCCCCCCCCCC	36.14	22985185
411	Phosphorylation	TARRPSVSENLYPPS EECCCCCCCCCCCCC	25.71	26270265
411	O-linked_Glycosylation	TARRPSVSENLYPPS EECCCCCCCCCCCCC	25.71	55824197
415	Phosphorylation	PSVSENLYPPSRKDQ CCCCCCCCCCCHHHC	25.36	26270265
418	O-linked_Glycosylation	SENLYPPSRKDQHRE CCCCCCCCHHHCCCC	47.67	55824203
418	Phosphorylation	SENLYPPSRKDQHRE CCCCCCCCHHHCCCC	47.67	26270265
434	Phosphorylation	PQTTRRPSKATSLES CCCCCCCCCCCCHHH	32.86	-
503	Phosphorylation	KAQDKILSNEYEEKY HHHHHHHCCHHHHHH	30.96	28355574
506	Phosphorylation	DKILSNEYEEKYDLS HHHHCCHHHHHHCCC	33.37	23911959
513	O-linked_Glycosylation	YEEKYDLSRPTASQL HHHHHCCCCCCHHHH	33.06	55830325
516	O-linked_Glycosylation	KYDLSRPTASQLEDE HHCCCCCCHHHHHHH	37.52	55830331
545	Sumoylation	KKHEKLEKPEKEKKK HHHHHCCCHHHHHHH	69.76	25218447
545	Sumoylation	KKHEKLEKPEKEKKK HHHHHCCCHHHHHHH	69.76	-
548	Sumoylation	EKLEKPEKEKKKKMK HHCCCHHHHHHHHHH	81.17	-
548	Sumoylation	EKLEKPEKEKKKKMK HHCCCHHHHHHHHHH	81.17	25218447
572	Phosphorylation	SEKQMKKSEKKSKQE HHHHHHHHHHHHHHH	49.48	26657352
575	Acetylation	QMKKSEKKSKQEKEK HHHHHHHHHHHHHHH	59.85	7367033
576	Phosphorylation	MKKSEKKSKQEKEKS HHHHHHHHHHHHHHH	51.11	26657352
577	Acetylation	KKSEKKSKQEKEKSK HHHHHHHHHHHHHHH	71.94	7367043
584	Acetylation	KQEKEKSKKKKGGKT HHHHHHHHHHCCCCC	78.62	20167786
586	Acetylation	EKEKSKKKKGGKTEQ HHHHHHHHCCCCCCC	61.46	20167786
602	Ubiquitination	GYQKPTNKHFTQSPK CCCCCCCCCCCCCCC	42.44	-
605	Phosphorylation	KPTNKHFTQSPKKSV CCCCCCCCCCCCCCH	28.05	-
607	Phosphorylation	TNKHFTQSPKKSVAD CCCCCCCCCCCCHHH	35.31	-
609	Ubiquitination	KHFTQSPKKSVADLL CCCCCCCCCCHHHHH	64.03	-
611	Phosphorylation	FTQSPKKSVADLLGS CCCCCCCCHHHHHHC	28.76	-
618	Phosphorylation	SVADLLGSFEGKRRL CHHHHHHCCCCCEEE	21.79	-
661	Phosphorylation	TRKISVITIFGPVNN HCCCEEEEEECCCCC	14.22	27174698
669	Phosphorylation	IFGPVNNSTMKIDHF EECCCCCCCCEEEEE	25.36	27174698
670	Phosphorylation	FGPVNNSTMKIDHFQ ECCCCCCCCEEEEEE	25.30	27174698
699	Phosphorylation	LVDQRLISELRKEYG HHCHHHHHHHHHHHC	34.86	24719451
732	Phosphorylation	QYYEVPITMKSVFDL EEEECCCCHHHHHHH	16.69	25690035
735	Phosphorylation	EVPITMKSVFDLIDT ECCCCHHHHHHHHHH	19.73	30622161
856	Phosphorylation	LVKDIRNYFQVSPEY HHHHHHHHHCCCHHH	5.87	30243723
860	Phosphorylation	IRNYFQVSPEYFSML HHHHHCCCHHHHCEE	10.96	30243723
863	Phosphorylation	YFQVSPEYFSMLLVG HHCCCHHHHCEEEEC	12.35	30243723
865	Phosphorylation	QVSPEYFSMLLVGKD CCCHHHHCEEEECCC	13.97	30243723
877	Phosphorylation	GKDGNVKSWYPSPMW CCCCCCCCCCCCCHH	27.79	-
890	Phosphorylation	MWSMVIVYDLIDSMQ HHHHHHHHHHHHHHH	8.23	-
895	Phosphorylation	IVYDLIDSMQLRRQE HHHHHHHHHHHHHHH	11.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
409	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
434	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD80_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD80_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD80_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.