| UniProt ID | RNF38_HUMAN | |
|---|---|---|
| UniProt AC | Q9H0F5 | |
| Protein Name | E3 ubiquitin-protein ligase RNF38 | |
| Gene Name | RNF38 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 515 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.. | |
| Protein Sequence | MACKISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHFKAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MACKISPGANSAS --CCCEECCCCCCCC | 11.63 | 24719451 | |
| 13 | Phosphorylation | SPGANSASLPGHPNK CCCCCCCCCCCCCCC | 34.61 | 24719451 | |
| 55 | Phosphorylation | HFKAFFQSEDSPSPK HHHHHHCCCCCCCHH | 37.91 | 29978859 | |
| 58 | Phosphorylation | AFFQSEDSPSPKRQR HHHCCCCCCCHHHHH | 24.19 | 25850435 | |
| 60 | Phosphorylation | FQSEDSPSPKRQRLS HCCCCCCCHHHHHCC | 47.18 | 25850435 | |
| 81 | Phosphorylation | TSASPAPSPPMRPWE CCCCCCCCCCCCCCC | 43.68 | 24719451 | |
| 119 | Phosphorylation | TPARNRRSPPVRRQR CCCHHCCCCCCHHHH | 30.25 | - | |
| 137 | Phosphorylation | DRLSRHNSISQDENY HHHHHCCCCCCCCCC | 19.93 | 27080861 | |
| 139 | Phosphorylation | LSRHNSISQDENYHH HHHCCCCCCCCCCCC | 31.25 | 27080861 | |
| 144 | Phosphorylation | SISQDENYHHLPYAQ CCCCCCCCCCCCHHH | 6.64 | 27080861 | |
| 149 | Phosphorylation | ENYHHLPYAQQQAIE CCCCCCCHHHHHHHH | 24.33 | 27080861 | |
| 167 | Phosphorylation | AFHPPNVSPRLLHPA HCCCCCCCHHHCCCC | 15.79 | 24719451 | |
| 327 | Ubiquitination | PVGGFTYPPSAHPPT CCCCCCCCCCCCCCC | 17.20 | 21963094 | |
| 357 (in isoform 3) | Ubiquitination | - | 3.75 | 21906983 | |
| 357 | Ubiquitination | HQEVSFGVPYPPFMP CCCCCCCCCCCCCCC | 3.75 | 21963094 | |
| 364 | Ubiquitination | VPYPPFMPRRLTGRS CCCCCCCCCCCCCCC | 20.72 | 21906983 | |
| 369 | Ubiquitination | FMPRRLTGRSRYRSQ CCCCCCCCCCCCCCC | 30.11 | 21963094 | |
| 390 | Ubiquitination | PYHPSLLPYVLSMLP CCCHHHHHHHHHCCC | 23.60 | 21963094 | |
| 390 (in isoform 2) | Ubiquitination | - | 23.60 | 21906983 | |
| 409 | Ubiquitination | VGPTFSFELDVEDGE CCCCEEEEEECCCCC | 42.75 | 29967540 | |
| 419 | Ubiquitination | VEDGEVENYEALLNL CCCCCEECHHHHHHH | 45.16 | - | |
| 434 | Acetylation | AERLGEAKPRGLTKA HHHHHCCCCCCCCHH | 30.83 | 12656617 | |
| 440 | Ubiquitination | AKPRGLTKADIEQLP CCCCCCCHHHHHHCC | 49.45 | 21963094 | |
| 440 (in isoform 1) | Ubiquitination | - | 49.45 | 21906983 | |
| 442 | Ubiquitination | PRGLTKADIEQLPSY CCCCCHHHHHHCCCC | 46.65 | 29967540 | |
| 448 | Phosphorylation | ADIEQLPSYRFNPNN HHHHHCCCCCCCCCC | 37.22 | 24719451 | |
| 492 | Ubiquitination | FHAKCVDKWLKANRT HHHHHHHHHHHHCCC | 33.75 | 29967540 | |
| 495 | Ubiquitination | KCVDKWLKANRTCPI HHHHHHHHHCCCCCC | 42.36 | - | |
| 514 | Phosphorylation | ASEVHRDSE------ HHHHHCCCC------ | 45.20 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNF38_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNF38_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNF38_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DTX3_HUMAN | DTX3 | physical | 22493164 | |
| RNF38_HUMAN | RNF38 | physical | 23973461 | |
| UB2D2_HUMAN | UBE2D2 | physical | 23973461 | |
| P53_HUMAN | TP53 | physical | 23973461 | |
| RNF38_HUMAN | RNF38 | physical | 25801170 | |
| UB2D2_HUMAN | UBE2D2 | physical | 25801170 | |
| UBC_HUMAN | UBC | physical | 25801170 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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