KLH17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH17_HUMAN
• UniProt AC: Q6TDP4
• Protein Name: Kelch-like protein 17
• Gene Name: KLHL17
• Organism: Homo sapiens (Human).
• Sequence Length: 642
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density..
• Protein Description: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity)..
• Protein Sequence: MQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQPRSERPAGRT ---CCCCCCCCCCCC	44.64	18767875
12	Phosphorylation	SERPAGRTQSPEHGS CCCCCCCCCCCCCCC	32.26	23663014
14	Phosphorylation	RPAGRTQSPEHGSPG CCCCCCCCCCCCCCC	31.48	23663014
19	Phosphorylation	TQSPEHGSPGPGPEA CCCCCCCCCCCCCCC	28.70	23663014
73	Methylation	SVAHNSKRHYHDAFV CCCCCCCCCHHHHHH	35.10	-
243	Phosphorylation	KQVLELVSSDSLNVP HHHHHHHCCCCCCCC	40.84	46158587
244	Phosphorylation	QVLELVSSDSLNVPS HHHHHHCCCCCCCCC	24.60	46158593
246	Phosphorylation	LELVSSDSLNVPSEE HHHHCCCCCCCCCHH	24.64	46158599
251	Phosphorylation	SDSLNVPSEEEVYRA CCCCCCCCHHHHHHH	54.05	46158605
287	Phosphorylation	CVRLPLLSRDFLLGH HHHHHHHCCCCHHCC	37.17	46158611
316	Ubiquitination	DLLIEALKFHLLPEQ HHHHHHHHHHCCHHH	37.47	-
374	Phosphorylation	DRWHVVASMSTRRAR CCEEEEEECCCCCHH	11.14	26852163
376	Phosphorylation	WHVVASMSTRRARVG EEEEEECCCCCHHEE	19.10	26852163
456	Phosphorylation	CLNSAERYDPLTGTW HCCCCCCCCCCCCCH	17.26	21577405
460	Phosphorylation	AERYDPLTGTWTSVA CCCCCCCCCCHHHHH	37.64	50563325
464	Phosphorylation	DPLTGTWTSVAAMST CCCCCCHHHHHHHHC	17.11	50563331
471	Phosphorylation	TSVAAMSTRRRYVRV HHHHHHHCCCCEEEE	18.34	5446471
515	Phosphorylation	NVWSPVASMLSRRSS CCHHHHHHHHHCCCC	22.08	108735601
518	Phosphorylation	SPVASMLSRRSSAGV HHHHHHHHCCCCCCE	19.60	108735607
541	Phosphorylation	VAGGNDGTSCLNSVE EECCCCCCCCHHHHH	21.09	22210691
553	Ubiquitination	SVERYSPKAGAWESV HHHHCCCCCCCCCCC	54.21	-
589	Phosphorylation	VGGNDGSSSLNSIEK ECCCCCCCCCCHHHH	44.36	46158617
593	Phosphorylation	DGSSSLNSIEKYNPR CCCCCCCHHHHHCCC	37.10	46158623
597	Phosphorylation	SLNSIEKYNPRTNKW CCCHHHHHCCCCCCE	20.01	46158629

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KLH17_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.