FBX33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX33_HUMAN
• UniProt AC: Q7Z6M2
• Protein Name: F-box only protein 33
• Gene Name: FBXO33
• Organism: Homo sapiens (Human).
• Sequence Length: 555
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity)..
• Protein Sequence: MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MLLFLSVPQPRPP --CEEEEECCCCCCC	25.15	-
185	Phosphorylation	WLEVLRTYLELVLCV HHHHHHHHHHHHHHH	7.55	-
195	Phosphorylation	LVLCVLVSIRNNRNL HHHHHHHHHHCCCCC	16.21	24719451
206	Phosphorylation	NRNLQKFSLFGDISV CCCCCCEEEECCHHH	29.80	26270265
212	Phosphorylation	FSLFGDISVLQQQGS EEEECCHHHHHHCCC	22.86	22210691
219	Phosphorylation	SVLQQQGSLSNTYLS HHHHHCCCCCCCCCC	25.04	22210691
221	Phosphorylation	LQQQGSLSNTYLSKV HHHCCCCCCCCCCCC	28.90	22210691
223	Phosphorylation	QQGSLSNTYLSKVDP HCCCCCCCCCCCCCC	23.59	22210691
224	Phosphorylation	QGSLSNTYLSKVDPD CCCCCCCCCCCCCCC	17.15	26270265
226	Phosphorylation	SLSNTYLSKVDPDGK CCCCCCCCCCCCCCH	21.88	26270265
256	Phosphorylation	SRQLKWLSCGFMLEI CCHHHHHHCCEEEEE	15.87	-
268	Phosphorylation	LEIVTPTSLSSLSNA EEECCCCCHHHHHHH	27.70	-
361	Ubiquitination	MPNDEHWKALSRKST CCCHHHHHHHHCCCC	41.16	29967540
367	Phosphorylation	WKALSRKSTSFRVYI HHHHHCCCCCEEEEE	28.33	23312004
368	Phosphorylation	KALSRKSTSFRVYIM HHHHCCCCCEEEEEE	34.61	23312004
369	Phosphorylation	ALSRKSTSFRVYIMA HHHCCCCCEEEEEEE	20.39	23312004
386	Ubiquitination	IKSEDMLKILKPSIP ECCHHHHHHHCCCCC	39.08	-
389	Ubiquitination	EDMLKILKPSIPLER HHHHHHHCCCCCHHH	39.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YBOX1_HUMAN	YBX1	physical	16797541

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.