| UniProt ID | FBXW8_HUMAN | |
|---|---|---|
| UniProt AC | Q8N3Y1 | |
| Protein Name | F-box/WD repeat-containing protein 8 | |
| Gene Name | FBXW8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 598 | |
| Subcellular Localization | Cytoplasm, perinuclear region . Golgi apparatus . Colocalizes with CUL7 at the Golgi apparatus in neurons. | |
| Protein Description | Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. [PubMed: 21572988 Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2)] | |
| Protein Sequence | MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLLEGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDDYSLDE -------CCCCCHHH | 8.80 | 22814378 | |
| 4 | Phosphorylation | ----MDDYSLDEFRR ----CCCCCHHHHHH | 13.58 | 27642862 | |
| 5 | Phosphorylation | ---MDDYSLDEFRRR ---CCCCCHHHHHHH | 36.02 | 24719451 | |
| 24 | Ubiquitination | LAQAQAPKKRRRPEA HHHCCCCHHHCCHHH | 63.03 | 29967540 | |
| 43 | Phosphorylation | ARRPEVGSGRGEQAS HHCCCCCCCCCCCCC | 30.41 | 28555341 | |
| 72 | Phosphorylation | RPPAARATRAEGQDV CCHHHHHHHHCCCCH | 25.51 | 24275569 | |
| 78 | Ubiquitination | ATRAEGQDVASRSRS HHHHCCCCHHHCCCC | 49.13 | 29967540 | |
| 83 | Phosphorylation | GQDVASRSRSPLARE CCCHHHCCCCCCHHC | 34.32 | 26699800 | |
| 85 | Phosphorylation | DVASRSRSPLAREGA CHHHCCCCCCHHCCC | 26.05 | 26699800 | |
| 144 | Ubiquitination | GRCAQVSKTWKVIAE CCCCCCCCCEEEEEE | 60.59 | 29967540 | |
| 157 | Ubiquitination | AEDEVLWYRLCQQEG EECHHHHHHHHHHCC | 6.91 | 21890473 | |
| 242 | Phosphorylation | WDTRTWDYVAPFLES EEECCCCEECCCCCC | 7.06 | 28102081 | |
| 246 | Ubiquitination | TWDYVAPFLESEDEE CCCEECCCCCCCCCC | 9.48 | 21890473 | |
| 249 | Phosphorylation | YVAPFLESEDEEDEP EECCCCCCCCCCCCC | 53.12 | 29507054 | |
| 288 | Phosphorylation | LNIWDLRTGKYPVHR EEEEECCCCCCCCEE | 45.37 | - | |
| 291 | Phosphorylation | WDLRTGKYPVHRFEH EECCCCCCCCEECCC | 16.31 | - | |
| 346 | Ubiquitination | FEVPKLVQYLEIVPE EECCHHHHHEEECCC | 47.75 | 21890473 | |
| 361 (in isoform 2) | Ubiquitination | - | 3.66 | 21890473 | |
| 361 | Ubiquitination | TRRYPVAVAAAGDLM CCCCCEEEEECHHHH | 3.66 | 21890473 | |
| 427 | Ubiquitination | EAGRRLLKLGNVLRD HHHHHHHHHCCCCCC | 59.96 | 22817900 | |
| 427 (in isoform 1) | Ubiquitination | - | 59.96 | 21890473 | |
| 428 | Ubiquitination | AGRRLLKLGNVLRDF HHHHHHHHCCCCCCE | 6.43 | 21890473 | |
| 464 | Phosphorylation | VRIHDLRSGNIALSL EEEEECCCCCEEEEE | 43.41 | 26425664 | |
| 470 | Phosphorylation | RSGNIALSLSAHQLR CCCCEEEEEEEEEEC | 15.97 | 26425664 | |
| 479 | Phosphorylation | SAHQLRVSAVQMDDW EEEEECEEEEECCCE | 19.11 | 22210691 | |
| 490 | Phosphorylation | MDDWKIVSGGEEGLV CCCEEEECCCCCCEE | 44.55 | 22210691 | |
| 498 | Phosphorylation | GGEEGLVSVWDYRMN CCCCCEEEEEEEECC | 23.64 | 22210691 | |
| 545 | Phosphorylation | MRNADLDSFTTHRRH HCCCCCCHHCCCHHH | 31.61 | 25850435 | |
| 547 | Phosphorylation | NADLDSFTTHRRHRG CCCCCHHCCCHHHHH | 26.16 | 25850435 | |
| 548 | Phosphorylation | ADLDSFTTHRRHRGL CCCCHHCCCHHHHHH | 16.04 | 25850435 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBXW8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBXW8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBXW8_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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