TSTD2_HUMAN - dbPTM
TSTD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSTD2_HUMAN
UniProt AC Q5T7W7
Protein Name Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Gene Name TSTD2
Organism Homo sapiens (Human).
Sequence Length 516
Subcellular Localization
Protein Description
Protein Sequence MPSSTSPDQGDDLENCILRFSDLDLKDMSLINPSSSLKAELDGSTKKKYSFAKKKAFALFVKTKEVPTKRSFECKEKLWKCCRQLFTDQTSIHRHVATQHADEIYHQTASILKQLAVTLSTSKSLSSADEKNPLKECLPHSHDVSAWLPDISCFNPDELISGQGSEEGEVLLYYCYHDLEDPQWICAWQTALCQHLHLTGKIRIAAEGINGTVGGSKLATRLYVEVMLSFPLFKDDLCKDDFKTSKGGAHCFPELRVGVFEEIVPMGISPKKISYKKPGIHLSPGEFHKEVEKFLSQANQEQSDTILLDCRNFYESKIGRFQGCLAPDIRKFSYFPSYVDKNLELFREKRVLMYCTGGIRCERGSAYLKAKGVCKEVFQLKGGIHKYLEEFPDGFYKGKLFVFDERYALSYNSDVVSECSYCGARWDQYKLCSTPQCRQLVLTCPACQGQGFTACCVTCQDKGSRKVSGPMQDSFKEECECTARRPRIPRELLQHVRQPVSPEPGPDADEDGPVLM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSSTSPDQG
-----CCCCCCCCCC		44.9725627689
4Phosphorylation----MPSSTSPDQGD
----CCCCCCCCCCC		27.3425627689
5Phosphorylation---MPSSTSPDQGDD
---CCCCCCCCCCCC		48.9225627689
6Phosphorylation--MPSSTSPDQGDDL
--CCCCCCCCCCCCH		28.5521815630
26UbiquitinationRFSDLDLKDMSLINP
HHHCCCCCCCCCCCC		51.5621906983
26 (in isoform 1)Ubiquitination-51.5621906983
29PhosphorylationDLDLKDMSLINPSSS
CCCCCCCCCCCCCCC		35.9128555341
38UbiquitinationINPSSSLKAELDGST
CCCCCCCCEECCCCC		41.5929967540
50PhosphorylationGSTKKKYSFAKKKAF
CCCCCCCHHHHHHEE		27.84-
57 (in isoform 2)Ubiquitination-9.2421906983
91UbiquitinationQLFTDQTSIHRHVAT
HHHCCCHHHHHHHHH		15.6821963094
110PhosphorylationEIYHQTASILKQLAV
HHHHHHHHHHHHHHH		31.6624719451
126PhosphorylationLSTSKSLSSADEKNP
HHCCCCCCCCCCCCC		30.4822468782
131UbiquitinationSLSSADEKNPLKECL
CCCCCCCCCCHHHHC		65.5027667366
217UbiquitinationNGTVGGSKLATRLYV
CCCCCCCHHHHHHHH		45.4722817900
217 (in isoform 1)Ubiquitination-45.4721906983
239UbiquitinationLFKDDLCKDDFKTSK
CCCCCCCCCCCCCCC		68.5729967540
246UbiquitinationKDDFKTSKGGAHCFP
CCCCCCCCCCCCCCH		67.6029967540
269PhosphorylationEIVPMGISPKKISYK
ECCCCCCCCCCCCCC		25.5725159151
272UbiquitinationPMGISPKKISYKKPG
CCCCCCCCCCCCCCC		40.02-
274PhosphorylationGISPKKISYKKPGIH
CCCCCCCCCCCCCCC		39.5222468782
277UbiquitinationPKKISYKKPGIHLSP
CCCCCCCCCCCCCCC		40.0029967540
283PhosphorylationKKPGIHLSPGEFHKE
CCCCCCCCCHHHHHH		19.3925159151
289UbiquitinationLSPGEFHKEVEKFLS
CCCHHHHHHHHHHHH		69.6329967540
293UbiquitinationEFHKEVEKFLSQANQ
HHHHHHHHHHHHHCH		57.7029967540
317UbiquitinationCRNFYESKIGRFQGC
CHHHHHHHHCCCCCC		36.9221963094
317 (in isoform 1)Ubiquitination-36.9221906983
331UbiquitinationCLAPDIRKFSYFPSY
CCCCCHHHHHCCHHH		38.7129967540
338PhosphorylationKFSYFPSYVDKNLEL
HHHCCHHHHHHCHHH		16.95-
386UbiquitinationQLKGGIHKYLEEFPD
HCCCCHHHHHHHCCC		50.0029967540
397UbiquitinationEFPDGFYKGKLFVFD
HCCCCCEECEEEEEC		47.5129967540
399UbiquitinationPDGFYKGKLFVFDER
CCCCEECEEEEECCC		34.30-
464PhosphorylationVTCQDKGSRKVSGPM
EEECCCCCCCCCCCC		34.3717924679
468PhosphorylationDKGSRKVSGPMQDSF
CCCCCCCCCCCCHHH		39.9717924679
474PhosphorylationVSGPMQDSFKEECEC
CCCCCCHHHHHHHHH		22.7117924679
476UbiquitinationGPMQDSFKEECECTA
CCCCHHHHHHHHHHC		57.4629967540
501PhosphorylationQHVRQPVSPEPGPDA
HHHCCCCCCCCCCCC		30.1722199227
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSTD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSTD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSTD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TSTD2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSTD2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-468 ANDSER-474, AND MASS SPECTROMETRY.

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