OAZ3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OAZ3_HUMAN
• UniProt AC: Q9UMX2
• Protein Name: Ornithine decarboxylase antizyme 3
• Gene Name: OAZ3
• Organism: Homo sapiens (Human).
• Sequence Length: 235
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. [PubMed: 17900240 Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity]
• Protein Sequence: MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PCKRCRPSVYSLSYI CCCCCCCCEEEEEEE	4.22	30622161
12	Phosphorylation	RCRPSVYSLSYIKRG CCCCCEEEEEEECCC	50.42	-
54	Phosphorylation	EKMLPRCYKSITYKE HHHCHHCEEECCCCC	9.42	-
56	Phosphorylation	MLPRCYKSITYKEEE HCHHCEEECCCCCHH	32.05	30622161
58	Phosphorylation	PRCYKSITYKEEEDL HHCEEECCCCCHHCC	19.92	30622161
60	2-Hydroxyisobutyrylation	CYKSITYKEEEDLTL CEEECCCCCHHCCCC	3.42	-
197	Phosphorylation	ALLRAFSYMGFEVVR HHHHHHHHCCCEEEC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OAZ3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OAZ3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OAZ3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMBL3_HUMAN	L3MBTL3	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
AZIN2_HUMAN	AZIN2	physical	25416956
AZIN1_HUMAN	AZIN1	physical	18062773
DCOR_HUMAN	ODC1	physical	18062773
AZIN1_HUMAN	AZIN1	physical	28514442
DCOR_HUMAN	ODC1	physical	28514442
FABP4_HUMAN	FABP4	physical	28514442
TRHY_HUMAN	TCHH	physical	28514442
LYPA2_HUMAN	LYPLA2	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
PADI3_HUMAN	PADI3	physical	28514442
IL1FA_HUMAN	IL1F10	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
MAOX_HUMAN	ME1	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442
DSG3_HUMAN	DSG3	physical	28514442
RGN_HUMAN	RGN	physical	28514442
PLAK_HUMAN	JUP	physical	28514442
CDSN_HUMAN	CDSN	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.