| UniProt ID | AZIN2_HUMAN | |
|---|---|---|
| UniProt AC | Q96A70 | |
| Protein Name | Antizyme inhibitor 2 | |
| Gene Name | AZIN2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 460 | |
| Subcellular Localization | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. C | |
| Protein Description | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. [PubMed: 17900240 Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production] | |
| Protein Sequence | MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCRHLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGFPGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLLDQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALRRQLMAAEQEDDVEGVCKPLSCGWEITDTLCVGPVFTPASIM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MAGYLSESDFVMV --CCCCCCHHHCEEE | 46159529 | ||
| 31 | Phosphorylation | KELTLGASQATTDEV HHHCCCCCCCCHHHH | 27174698 | ||
| 34 | Phosphorylation | TLGASQATTDEVAAF CCCCCCCCHHHHHHH | 27174698 | ||
| 35 | Phosphorylation | LGASQATTDEVAAFF CCCCCCCHHHHHHHH | 27174698 | ||
| 174 | Phosphorylation | LSLKFGVSLKSCRHL HHHHHCCCHHHHHHH | 24719451 | ||
| 338 | Phosphorylation | LFDNICPTPILQKKP HCCCCCCCCCCCCCC | 25332170 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AZIN2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AZIN2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AZIN2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| OAZ1_HUMAN | OAZ1 | physical | 28514442 | |
| OAZ2_HUMAN | OAZ2 | physical | 28514442 | |
| CORO7_HUMAN | CORO7 | physical | 28514442 | |
| PRAME_HUMAN | PRAME | physical | 28514442 | |
| TPD53_HUMAN | TPD52L1 | physical | 28514442 | |
| SMAL1_HUMAN | SMARCAL1 | physical | 28514442 | |
| LRIF1_HUMAN | LRIF1 | physical | 28514442 | |
| DDX11_HUMAN | DDX11 | physical | 28514442 | |
| SMG8_HUMAN | SMG8 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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