IL1FA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL1FA_HUMAN
• UniProt AC: Q8WWZ1
• Protein Name: Interleukin-1 family member 10
• Gene Name: IL1F10
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Subcellular Localization: Secreted.
• Protein Description: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2..
• Protein Sequence: MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	CSLPMARYYIIKYAD CCCCCCEEEHHEECC	6.89	-
14	Phosphorylation	ARYYIIKYADQKALY CEEEHHEECCCCEEE	12.66	-
105	Phosphorylation	RFTFFQSSSGSAFRL EEEEEECCCCCEEEE	28.12	-
106	Phosphorylation	FTFFQSSSGSAFRLE EEEEECCCCCEEEEE	41.85	-
108	Phosphorylation	FFQSSSGSAFRLEAA EEECCCCCEEEEEEE	26.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL1FA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL1FA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL1FA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IL1FA_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.