| UniProt ID | RGN_HUMAN | |
|---|---|---|
| UniProt AC | Q15493 | |
| Protein Name | Regucalcin | |
| Gene Name | RGN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 299 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).. | |
| Protein Sequence | MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSSVALRQSGGYVATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAEETAPAVLERHQGALYSLFPDHHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDYDLQTGQISNRRSVYKLEKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRLQTVKLPVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGGIFKITGLGVKGIAPYSYAG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | KKVCRWDSFTKQVQR HHEECHHHHCHHEEE | 28.05 | 24719451 | |
| 46 | Phosphorylation | VCRWDSFTKQVQRVT EECHHHHCHHEEEEC | 25.23 | 17081983 | |
| 60 | Phosphorylation | TMDAPVSSVALRQSG CCCCCCCCEEEHHCC | 16.19 | 19664995 | |
| 66 | Phosphorylation | SSVALRQSGGYVATI CCEEEHHCCCEEEEE | 27.96 | - | |
| 86 | Phosphorylation | ALNWKEQSAVVLATV ECCCCCCEEEEEEEE | 24.91 | 24114839 | |
| 144 | Succinylation | LFPDHHVKKYFDQVD HCCHHHHHHHHCEEE | 37.08 | - | |
| 144 | Succinylation | LFPDHHVKKYFDQVD HCCHHHHHHHHCEEE | 37.08 | - | |
| 172 | Phosphorylation | FYYIDSLSYSVDAFD EEEEHEECEEEEEEC | 21.22 | 18491316 | |
| 244 | Acetylation | TVKLPVDKTTSCCFG EEECCCCCCCCCCCC | 54.67 | 25953088 | |
| 244 | Succinylation | TVKLPVDKTTSCCFG EEECCCCCCCCCCCC | 54.67 | - | |
| 244 | Succinylation | TVKLPVDKTTSCCFG EEECCCCCCCCCCCC | 54.67 | - | |
| 253 | Succinylation | TSCCFGGKNYSEMYV CCCCCCCCCCEEEEE | 53.76 | - | |
| 253 | Succinylation | TSCCFGGKNYSEMYV CCCCCCCCCCEEEEE | 53.76 | - | |
| 255 | Phosphorylation | CCFGGKNYSEMYVTC CCCCCCCCEEEEEEE | 14.97 | 22964224 | |
| 256 | Phosphorylation | CFGGKNYSEMYVTCA CCCCCCCEEEEEEEE | 25.86 | 22964224 | |
| 259 | Phosphorylation | GKNYSEMYVTCARDG CCCCEEEEEEEECCC | 6.64 | 22964224 | |
| 261 | Phosphorylation | NYSEMYVTCARDGMD CCEEEEEEEECCCCC | 5.29 | 22964224 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RGN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RGN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RGN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HINT1_HUMAN | HINT1 | physical | 26344197 | |
| WDR1_HUMAN | WDR1 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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