EFHC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFHC1_HUMAN
• UniProt AC: Q5JVL4
• Protein Name: EF-hand domain-containing protein 1
• Gene Name: EFHC1
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole .
• Protein Description: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. [PubMed: 19734894]
• Protein Sequence: MVSNPVHGLPFLPGTSFKDSTKTAFHRSQTLSYRNGYAIVRRPTVGIGGDRLQFNQLSQAELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQVNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQRLAKNDRGDHYHWKDLNRGINITIYGKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRVPKVLVENAKNFPQCVLEISDQEVLEWYTAKDFIVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITDLPRIDVSKREPPPVKQELPPYNGFGLVEDSAQNCFALIPKAPKKDVIKMLVNDNKVLRYLAVLESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTVDNPVYYGPSDFFIGAVIEVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRKREAPAPEAESKQTEKDPGVQELEALIDTIQKQLKDHSCKDNIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYNFVRAFSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Acetylation	FLPGTSFKDSTKTAF CCCCCCCCCCCCCCC	51.00	25038526
30	Phosphorylation	TAFHRSQTLSYRNGY CCCHHHCCCEEECCE	20.93	28857561
58	Phosphorylation	RLQFNQLSQAELDEL CCCCCCCCHHHHHHH	19.99	30622161
102	Phosphorylation	KVLKFDAYFQEDVPM CCCCEEEECCCCCCC	13.98	24425749
111	Phosphorylation	QEDVPMSTEEQYRIR CCCCCCCHHHHHEEE	36.97	-
115	Phosphorylation	PMSTEEQYRIRQVNI CCCHHHHHEEEEEEE	15.99	24425749
212	Phosphorylation	EKMALDPYTELRKQP HHHCCCCCHHHHCCC	16.71	27642862
227	Phosphorylation	LRKYVTPSDFDQLKQ HHHCCCHHHHHHHHH	41.36	25693802
233	Acetylation	PSDFDQLKQFLTFDK HHHHHHHHHHHHCCH	33.11	25038526
237	Phosphorylation	DQLKQFLTFDKQVLR HHHHHHHHCCHHHHH	30.95	26657352
246	Phosphorylation	DKQVLRFYAIWDDTD CHHHHHHEEEECCCC	7.25	26657352
254	Phosphorylation	AIWDDTDSMYGECRT EEECCCCCCHHHHHE	18.92	26657352
341	Phosphorylation	SLTILGRTFFIYDCD CEEECCCEEEEEECC	22.54	-
345	Phosphorylation	LGRTFFIYDCDPFTR CCCEEEEEECCHHHH	12.83	-
351	Phosphorylation	IYDCDPFTRRYYKEK EEECCHHHHHHHHHH	21.45	-
358	Ubiquitination	TRRYYKEKFGITDLP HHHHHHHHHCCCCCC	44.75	-
465	Acetylation	NSGIIGGKYLGRTKV CCCCCCCEECCCCEE	31.89	25038526
523	Phosphorylation	MESNAAQYSPEALAS HHHCHHHCCHHHHHH	22.82	28555341
524	Phosphorylation	ESNAAQYSPEALASI HHCHHHCCHHHHHHH	12.27	25159151
548	Acetylation	PAPEAESKQTEKDPG CCCHHHHHCCCCCCC	53.39	25038526
552	Acetylation	AESKQTEKDPGVQEL HHHHCCCCCCCHHHH	73.02	25038526
588	Acetylation	EAFQIYDKEASGYVD HHHHHHCCCCCCCCC	37.90	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFHC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFHC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFHC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRAP_HUMAN	BRAP	physical	28514442
HAUS4_HUMAN	HAUS4	physical	28514442
HAUS1_HUMAN	HAUS1	physical	28514442
CC150_HUMAN	CCDC150	physical	27173435
COA7_HUMAN	COA7	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.