FOLC_HUMAN - dbPTM
FOLC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOLC_HUMAN
UniProt AC Q05932
Protein Name Folylpolyglutamate synthase, mitochondrial
Gene Name FPGS
Organism Homo sapiens (Human).
Sequence Length 587
Subcellular Localization Isoform 1: Mitochondrion inner membrane . Mitochondrion matrix .
Isoform 2: Cytoplasm .
Protein Description Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates..
Protein Sequence MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16UbiquitinationRAALFLAAASARGIT
HHHHHHHHHHHCCHH		12.2322817900
24 (in isoform 2)Ubiquitination-21.0821890473
43AcetylationPVPQEPSMEYQDAVR
CCCCCCCCCHHHHHH		8.9922814378
45PhosphorylationPQEPSMEYQDAVRML
CCCCCCCHHHHHHHH		11.7527642862
54PhosphorylationDAVRMLNTLQTNAGY
HHHHHHHHHHHCHHH		19.1130622161
55UbiquitinationAVRMLNTLQTNAGYL
HHHHHHHHHHCHHHH		6.0229967540
57PhosphorylationRMLNTLQTNAGYLEQ
HHHHHHHHCHHHHHH		30.1030622161
57UbiquitinationRMLNTLQTNAGYLEQ
HHHHHHHHCHHHHHH		30.1029967540
61PhosphorylationTLQTNAGYLEQVKRQ
HHHHCHHHHHHHHHH		12.4927642862
66UbiquitinationAGYLEQVKRQRGDPQ
HHHHHHHHHHCCCHH		42.3721906983
66 (in isoform 1)Ubiquitination-42.3721890473
74UbiquitinationRQRGDPQTQLEAMEL
HHCCCHHHHHHHHHH		40.2722505724
104UbiquitinationNIIHVTGTKGKGSTC
EEEEEECCCCCCCCC		27.5323000965
105UbiquitinationIIHVTGTKGKGSTCA
EEEEECCCCCCCCCH		61.0329967540
107UbiquitinationHVTGTKGKGSTCAFT
EEECCCCCCCCCHHH		51.7729967540
112UbiquitinationKGKGSTCAFTECILR
CCCCCCCHHHHHHHH		17.9321890473
112 (in isoform 2)Ubiquitination-17.9321890473
112UbiquitinationKGKGSTCAFTECILR
CCCCCCCHHHHHHHH		17.9321890473
124UbiquitinationILRSYGLKTGFFSSP
HHHHCCCCCCCCCCC		42.0922505724
154 (in isoform 1)Ubiquitination-30.9921890473
154UbiquitinationISPELFTKYFWRLYH
CCHHHHHHHHHHHHH		30.9923000965
154UbiquitinationISPELFTKYFWRLYH
CCHHHHHHHHHHHHH		30.9921890473
165UbiquitinationRLYHRLEETKDGSCV
HHHHHHHHCCCCCCC		66.7929967540
188UbiquitinationLTLMAFHVFLQEKVD
HHHHHHHHHHHHCCC		4.0722817900
189UbiquitinationTLMAFHVFLQEKVDL
HHHHHHHHHHHCCCE		4.3529967540
193UbiquitinationFHVFLQEKVDLAVVE
HHHHHHHCCCEEEEE		28.2627667366
198UbiquitinationQEKVDLAVVEVGIGG
HHCCCEEEEEECCCC		4.9821963094
201 (in isoform 2)Ubiquitination-4.5921890473
206 (in isoform 2)Ubiquitination-7.5621890473
212UbiquitinationGAYDCTNIIRKPVVC
CCCCCCHHCCCCEEE		1.4122817900
215UbiquitinationDCTNIIRKPVVCGVS
CCCHHCCCCEEEECH		31.5829967540
217UbiquitinationTNIIRKPVVCGVSSL
CHHCCCCEEEECHHC		6.6227667366
222UbiquitinationKPVVCGVSSLGIDHT
CCEEEECHHCCCCCH		12.7221963094
238UbiquitinationLLGDTVEKIAWQKGG
HHCHHHHHHHHHHCC		33.1322817900
243UbiquitinationVEKIAWQKGGIFKQG
HHHHHHHHCCHHHCC		48.6921906983
243 (in isoform 1)Ubiquitination-48.6921890473
248UbiquitinationWQKGGIFKQGVPAFT
HHHCCHHHCCCCEEE		44.1921963094
248 (in isoform 1)Ubiquitination-44.1921890473
329UbiquitinationRHGAGEPKASRPGLL
CCCCCCCCCCCCCCE		55.48-
403PhosphorylationLQGRERPSGGPEVRV
HCCCCCCCCCCCEEE		63.7028674419
539PhosphorylationDPIFQPPSPPKGLLT
CCCCCCCCCCCCCCC		61.5926055452
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOLC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOLC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOLC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FOLC_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00563Methotrexate
DB06813Pralatrexate
DB00293Raltitrexed
Regulatory Network of FOLC_HUMAN

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Related Literatures of Post-Translational Modification

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