CELR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CELR3_HUMAN
• UniProt AC: Q9NYQ7
• Protein Name: Cadherin EGF LAG seven-pass G-type receptor 3
• Gene Name: CELSR3
• Organism: Homo sapiens (Human).
• Sequence Length: 3312
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor that may have an important role in cell/cell signaling during nervous system formation..
• Protein Sequence: MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGALALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGSRERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHHGPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAAVRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGARRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPEPEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTMFLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLDVAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHPKDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSLGRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLSQPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGSTLPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQLSRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPSTEQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELSPDSEVPRSEGHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Methylation	LAATTGPRAHIGGGA HHCCCCCCCCCCCCC	39.89	-
131	Phosphorylation	ETGQGPGSVLYWRPE CCCCCCCCEEEECCC	16.45	30631047
140	Phosphorylation	LYWRPEVSSCGRTGP EEECCCCCCCCCCCC	20.46	30631047
141	Phosphorylation	YWRPEVSSCGRTGPL EECCCCCCCCCCCCC	26.26	30631047
265	Phosphorylation	SGSAPRESRTAPEPA CCCCCCCCCCCCCCC	35.89	-
370	Phosphorylation	SLAALMNSRSLELFS HHHHHHCCCCEEEEE	14.85	-
534	Phosphorylation	ATVRVHITVLDENDN EEEEEEEEEECCCCC	10.51	-
632	N-linked_Glycosylation	AGRPPLSNNTGLASI CCCCCCCCCCCCCEE	58.74	UniProtKB CARBOHYD
773	Phosphorylation	NEDAAVGTSVVSVTA CCCCCCCCEEEEEEE	16.26	27251275
774	Phosphorylation	EDAAVGTSVVSVTAV CCCCCCCEEEEEEEE	18.00	27251275
777	Phosphorylation	AVGTSVVSVTAVDRD CCCCEEEEEEEECCC	16.17	27251275
779	Phosphorylation	GTSVVSVTAVDRDAN CCEEEEEEEECCCCC	17.29	27251275
787	Phosphorylation	AVDRDANSAISYQIT EECCCCCCCEEEEEE	28.80	27251275
790	Phosphorylation	RDANSAISYQITGGN CCCCCCEEEEEECCC	15.65	27251275
794	Phosphorylation	SAISYQITGGNTRNR CCEEEEEECCCCCCC	24.42	27251275
798	Phosphorylation	YQITGGNTRNRFAIS EEEECCCCCCCEEEE	32.37	27251275
805	Phosphorylation	TRNRFAISTQGGVGL CCCCEEEECCCCCEE	15.96	18669648
806	Phosphorylation	RNRFAISTQGGVGLV CCCEEEECCCCCEEE	25.72	18669648
821	Phosphorylation	TLALPLDYKQERYFK EEEEECCCCCHHHEE	23.43	18669648
847	N-linked_Glycosylation	DHCYVHINITDANTH CCEEEEEECCCCCCC	19.07	UniProtKB CARBOHYD
1182	N-linked_Glycosylation	LFNNYVSNRSDTFPS HHCCHHCCCCCCCCC	37.11	UniProtKB CARBOHYD
1198	Phosphorylation	IIGRIPAYDPDVSDH CCCCCCCCCCCCCCC	23.74	-
1203	Phosphorylation	PAYDPDVSDHLFYSF CCCCCCCCCCEEEEC	27.05	-
1208	Phosphorylation	DVSDHLFYSFERGNE CCCCCEEEECCCCCE	20.86	-
1209	Phosphorylation	VSDHLFYSFERGNEL CCCCEEEECCCCCEE	17.19	-
1222	N-linked_Glycosylation	ELQLLVVNQTSGELR EEEEEEEECCCCCEE	31.75	UniProtKB CARBOHYD
1317	N-linked_Glycosylation	VFIFNIQNDTDVGGT EEEEEEECCCCCCCE	50.80	UniProtKB CARBOHYD
1327	N-linked_Glycosylation	DVGGTVLNVSFSALA CCCCEEEEEEEEEEC	24.05	UniProtKB CARBOHYD
1398	Phosphorylation	VSVLRFDSSAPFLAS EEEEEECCCCCCCCC	26.20	22210691
1405	Phosphorylation	SSAPFLASASTLFRP CCCCCCCCHHHHCCC	25.54	22210691
1408	Phosphorylation	PFLASASTLFRPIQP CCCCCHHHHCCCCCC	29.63	22210691
1580	Phosphorylation	QVRLTYSTGESNTVV EEEEEEECCCCCEEE	34.26	-
1649	N-linked_Glycosylation	QFGAEIGNYSCAAAG HCCCEECCCCHHHCC	31.07	UniProtKB CARBOHYD
1713	N-linked_Glycosylation	MAAFVANNGTMAGCQ EEEEEECCCCCCCCE	37.26	UniProtKB CARBOHYD
1715	Phosphorylation	AFVANNGTMAGCQAK EEEECCCCCCCCEEE	13.13	24114839
1770	N-linked_Glycosylation	HPHHFRGNGTLSWNF CCCCCCCCCEEEECC	35.70	UniProtKB CARBOHYD
1963	Hydroxylation	PPHADCRDLWQTFSC CCCCCHHHHHHHCCC	59.60	-
2053	N-linked_Glycosylation	KGFDPNCNKTNGQCH CCCCCCCCCCCCEEE	61.91	UniProtKB CARBOHYD
2062	Ubiquitination	TNGQCHCKEFHYRPR CCCEEEECCCCCCCC	39.49	-
2062 (in isoform 2)	Ubiquitination	-	39.49	-
2126	Phosphorylation	ASGCRVLYDACPKSL CCCCEEEEHHCCHHH	9.91	-
2131	Ubiquitination	VLYDACPKSLRSGVW EEEHHCCHHHHCCCC	63.10	-
2131 (in isoform 2)	Ubiquitination	-	63.10	-
2143	Ubiquitination	GVWWPQTKFGVLATV CCCCCCCCCEEEEEE	34.57	-
2143 (in isoform 2)	Ubiquitination	-	34.57	-
2149	Phosphorylation	TKFGVLATVPCPRGA CCCEEEEEEECCCCH	22.33	-
2177	N-linked_Glycosylation	WLEPDLFNCTSPAFR CCCCCHHCCCCHHHH	35.14	UniProtKB CARBOHYD
2180	Phosphorylation	PDLFNCTSPAFRELS CCHHCCCCHHHHHHH	19.21	24719451
2196	N-linked_Glycosylation	LLDGLELNKTALDTM HHHHHHCCHHHHHHH	30.20	UniProtKB CARBOHYD
2197	Ubiquitination	LDGLELNKTALDTME HHHHHCCHHHHHHHH	48.04	-
2202 (in isoform 2)	Ubiquitination	-	20.12	-
2206	Ubiquitination	ALDTMEAKKLAQRLR HHHHHHHHHHHHHHH	34.71	-
2207	Ubiquitination	LDTMEAKKLAQRLRE HHHHHHHHHHHHHHH	56.98	-
2212 (in isoform 2)	Ubiquitination	-	3.49	-
2386	N-linked_Glycosylation	PTSSSIENSTTSSVV CCCCCCCCCCCCCCC	42.88	UniProtKB CARBOHYD
2474	N-linked_Glycosylation	FRLLQTANRSKAICV HHHHHCCCCCCCEEE	52.74	UniProtKB CARBOHYD
2477	Ubiquitination	LQTANRSKAICVQWD HHCCCCCCCEEEECC	38.23	-
2482 (in isoform 2)	Ubiquitination	-	34.15	-
2506	N-linked_Glycosylation	DCELVHRNGSHARCR HCEEEECCCCCCEEE	41.25	UniProtKB CARBOHYD
2508	Phosphorylation	ELVHRNGSHARCRCS EEEECCCCCCEEEEC	19.95	22617229
2790	Ubiquitination	MPACLGRKAAPEEAR CHHHHCCCCCCHHHC	47.29	-
2795 (in isoform 2)	Ubiquitination	-	49.25	-
2826	Phosphorylation	IRITLGASTVSSVSS EEEEECCCCCCCHHH	27.78	-
2861	Phosphorylation	NVLVRHGSAADHTDH CEEEECCCCCCCCCC	17.73	28348404
2866	Phosphorylation	HGSAADHTDHSLQAH CCCCCCCCCCCCHHC	35.63	28348404
2869	Phosphorylation	AADHTDHSLQAHAGP CCCCCCCCCHHCCCC	25.61	28348404
2877	Phosphorylation	LQAHAGPTDLDVAMF CHHCCCCCCCEEEEE	48.56	28348404
2892	Phosphorylation	HRDAGADSDSDSDLS ECCCCCCCCCCCCCC	38.18	27732954
2894	Phosphorylation	DAGADSDSDSDLSLE CCCCCCCCCCCCCHH	42.86	27732954
2896	Phosphorylation	GADSDSDSDLSLEEE CCCCCCCCCCCHHHH	44.39	27732954
2899	Phosphorylation	SDSDSDLSLEEERSL CCCCCCCCHHHHHHC	38.43	27732954
2993	Phosphorylation	NQPDPALTSGDETSL CCCCCCCCCCCCCHH	32.54	21955146
2994	Phosphorylation	QPDPALTSGDETSLG CCCCCCCCCCCCHHH	45.13	21955146
2998	Phosphorylation	ALTSGDETSLGRAQR CCCCCCCCHHHHHHH	33.71	21955146
2999	Phosphorylation	LTSGDETSLGRAQRQ CCCCCCCHHHHHHHH	27.12	21955146
3017	Phosphorylation	ILKNRLQYPLVPQTR HHHCCCCCCCCCCCC	11.79	25884760
3051	Phosphorylation	AASYGRIYAGGGTGS HHHCCCEECCCCCCC	9.61	25884760
3056	Phosphorylation	RIYAGGGTGSLSQPA CEECCCCCCCCCCCC	27.20	28555341
3058	Phosphorylation	YAGGGTGSLSQPASR ECCCCCCCCCCCCHH	25.37	27732954
3060	Phosphorylation	GGGTGSLSQPASRYS CCCCCCCCCCCHHCC	35.50	20639409
3064	O-linked_Glycosylation	GSLSQPASRYSSREQ CCCCCCCHHCCCHHH	38.13	29237092
3064	Phosphorylation	GSLSQPASRYSSREQ CCCCCCCHHCCCHHH	38.13	27732954
3066	Phosphorylation	LSQPASRYSSREQLD CCCCCHHCCCHHHHH	14.43	24117733
3067	Phosphorylation	SQPASRYSSREQLDL CCCCHHCCCHHHHHH	23.08	24117733
3068	Phosphorylation	QPASRYSSREQLDLL CCCHHCCCHHHHHHH	30.79	24117733
3081	Phosphorylation	LLLRRQLSRERLEEA HHHHHHHCHHHHHHC	24.61	-
3097	Phosphorylation	APVLRPLSRPGSQEC CCCCCCCCCCCCHHH	38.83	24719451
3119	Phosphorylation	LEPKDRGSTLPRRQP CCCCCCCCCCCCCCC	27.88	24719451
3120	Phosphorylation	EPKDRGSTLPRRQPP CCCCCCCCCCCCCCC	43.54	24719451
3140	Phosphorylation	AMAGRFGSRDALDLG CCCCCCCCCCCHHCC	25.03	20639409
3175	Phosphorylation	QPPPLPLSPQRQLSR CCCCCCCCCCCCCCC	19.63	21712546
3181	Phosphorylation	LSPQRQLSRDPLLPS CCCCCCCCCCCCCCC	26.71	28348404
3188	Phosphorylation	SRDPLLPSRPLDSLS CCCCCCCCCCHHHCC	46.64	22210691
3193	Phosphorylation	LPSRPLDSLSRSSNS CCCCCHHHCCCCCCC	35.61	26437602
3195	Phosphorylation	SRPLDSLSRSSNSRE CCCHHHCCCCCCCHH	33.78	22673903
3197	Phosphorylation	PLDSLSRSSNSREQL CHHHCCCCCCCHHHH	30.41	22210691
3200	Phosphorylation	SLSRSSNSREQLDQV HCCCCCCCHHHHHCC	38.86	22210691
3209	Phosphorylation	EQLDQVPSRHPSREA HHHHCCCCCCCCHHH	44.35	26552605
3213	Phosphorylation	QVPSRHPSREALGPL CCCCCCCCHHHHCCH	36.31	32142685
3295	Phosphorylation	PRSATSHSISELSPD CCCCCCCCCCCCCCC	27.81	32142685
3297	Phosphorylation	SATSHSISELSPDSE CCCCCCCCCCCCCCC	35.18	32142685
3300	Phosphorylation	SHSISELSPDSEVPR CCCCCCCCCCCCCCC	23.70	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CELR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CELR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CELR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWP70_HUMAN	SWAP70	physical	12421765
DYST_HUMAN	DST	physical	12421765

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.