CSTN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSTN1_HUMAN
• UniProt AC: O94985
• Protein Name: Calsyntenin-1
• Gene Name: CLSTN1
• Organism: Homo sapiens (Human).
• Sequence Length: 981
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane . Cell projection . Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Nucleus . Neurite tips. Localized in the post
• Protein Description: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity)..
• Protein Sequence: MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	O-linked_Glycosylation	HKPWLEPTYHGIVTE CCCCCCCCCCEEECC	20.83	OGP
52	O-linked_Glycosylation	IVTENDNTVLLDPPL EECCCCCEEEECCCE	18.52	OGP
112	Phosphorylation	TGEGVIRSKEKLDCE CCCCEEECCCCCCCE	33.76	26091039
149	O-linked_Glycosylation	VKKSHKATVHIQVND CCCCCEEEEEEEECC	19.88	OGP
167 (in isoform 2)	Ubiquitination	-	60.73	21906983
167	Ubiquitination	YAPVFKEKSYKATVI CCCCCCCCCEEEEEE	60.73	-
170	Ubiquitination	VFKEKSYKATVIEGK CCCCCCEEEEEECCC	44.68	-
177 (in isoform 1)	Ubiquitination	-	32.66	21906983
177	Ubiquitination	KATVIEGKQYDSILR EEEEECCCCCCEEEE	32.66	2190698
181	Phosphorylation	IEGKQYDSILRVEAV ECCCCCCEEEEEEEE	20.70	24719451
224	Ubiquitination	GYIKNTEKLNYGKEH CCCCCCCCCCCCCCC	39.74	-
229	Ubiquitination	TEKLNYGKEHQYKLT CCCCCCCCCCEEEEE	41.48	-
346	N-linked_Glycosylation	PSPSGSLNWTMGLPT CCCCCCCEEEEECCC	33.59	UniProtKB CARBOHYD
366	N-linked_Glycosylation	SDQVFEFNGTQAVRI CCCEEEECCEEEEEC	45.46	UniProtKB CARBOHYD
407	Phosphorylation	KKETILCSSDKTDMN CCCEEEEECCCCCCC	37.82	-
408	Phosphorylation	KETILCSSDKTDMNR CCEEEEECCCCCCCH	41.97	-
418	Phosphorylation	TDMNRHHYSLYVHGC CCCCHHHHEEEEECE	8.34	-
421	Phosphorylation	NRHHYSLYVHGCRLI CHHHHEEEEECEEEE	5.62	-
473	Phosphorylation	EFPSVTLYVDGTSHE ECCEEEEEECCCCCC	6.27	22468782
515	N-linked_Glycosylation	FSGVENDNETEPVTV HCCCCCCCCCCCEEE	70.44	UniProtKB CARBOHYD
553	Acetylation	SGKLADKKVIDCLYT CCCCCCHHHHHHEEE	44.99	24431067
791	Ubiquitination	SLLDRKFKLICSELN HHHHHHHHHHHHHHC	39.72	-
977	Phosphorylation	QQLEWDDSTLSY--- HHHHCCCCCCCC---	28.86	28348404
978	Phosphorylation	QLEWDDSTLSY---- HHHCCCCCCCC----	27.07	24719451
980	Phosphorylation	EWDDSTLSY------ HCCCCCCCC------	100.00	28348404
981	Phosphorylation	WDDSTLSY------- CCCCCCCC-------	100.00	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSTN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSTN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSTN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBA2_HUMAN	APBA2	physical	15037614
A4_HUMAN	APP	physical	15037614
PSN1_HUMAN	PSEN1	physical	15037614
TRIPC_HUMAN	TRIP12	physical	12421765
SETB1_HUMAN	SETDB1	physical	12421765
SLK_HUMAN	SLK	physical	12421765
GANP_HUMAN	MCM3AP	physical	12421765
BAHC1_HUMAN	BAHCC1	physical	12421765

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.