dbPTM

R144A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	R144A_HUMAN
UniProt AC	P50876
Protein Name	E3 ubiquitin-protein ligase RNF144A
Gene Name	RNF144A
Organism	Homo sapiens (Human).
Sequence Length	292
Subcellular Localization	Cell membrane Single-pass membrane protein . Cytoplasmic vesicle membrane .
Protein Description	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC..
Protein Sequence	MTTTRYRPTWDLALDPLVSCKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDVGLQTPQPVQCKACRMEFCSTCKASWHPGQGCPETMPITFLPGETSAAFKMEEDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVLCCKCKCSKGDDDPLPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Ubiquitination	EEDDAPIKRCPKCKV CCCCCCCCCCCCCEE	47.06	-
187	Sumoylation	APIKRCPKCKVYIER CCCCCCCCCEEEEEC	50.76	-
189	Sumoylation	IKRCPKCKVYIERDE CCCCCCCEEEEECCC	44.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of R144A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of R144A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of R144A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKDC_HUMAN	PRKDC	physical	24979766
R144A_HUMAN	RNF144A	physical	24979766
UB2L3_HUMAN	UBE2L3	physical	24979766
CKAP4_HUMAN	CKAP4	physical	26186194
R144A_HUMAN	RNF144A	physical	26216882
CKAP4_HUMAN	CKAP4	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of R144A_HUMAN

Related Literatures of Post-Translational Modification