JOS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JOS1_HUMAN
• UniProt AC: Q15040
• Protein Name: Josephin-1
• Gene Name: JOSD1
• Organism: Homo sapiens (Human).
• Sequence Length: 202
• Subcellular Localization: Cell membrane . Cytoplasm . Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
• Protein Description: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity..
• Protein Sequence: MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCVPWKGD ------CCCCCCCCC	24.66	26074081
12	Ubiquitination	PWKGDKAKSESLELP CCCCCHHCCCCCCCC	61.57	-
13	Phosphorylation	WKGDKAKSESLELPQ CCCCHHCCCCCCCCC	36.96	23401153
15	Phosphorylation	GDKAKSESLELPQAA CCHHCCCCCCCCCCC	33.95	23927012
27	Phosphorylation	QAAPPQIYHEKQRRE CCCCCCCCCHHHHHH	9.93	23403867
30	Ubiquitination	PPQIYHEKQRRELCA CCCCCCHHHHHHHHH	35.47	-
70	Phosphorylation	LSPNTMVTPHKKSML HCCCCEECCCCHHHC	14.62	28674419
73	Ubiquitination	NTMVTPHKKSMLGNG CCEECCCCHHHCCCC	47.98	-
74	Ubiquitination	TMVTPHKKSMLGNGN CEECCCCHHHCCCCC	37.76	21906983
158	Ubiquitination	YNLDSKLKMPEWIGG EECCCCCCCCHHHCC	57.03	21906983
174	Ubiquitination	SELRKFLKHHLRGKN HHHHHHHHHHHCCCC	31.92	-
180	Ubiquitination	LKHHLRGKNCELLLV HHHHHCCCCCEEEEE	52.57	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JOS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JOS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JOS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIM8A_HUMAN	TIMM8A	physical	19615732
UBC_HUMAN	UBC	physical	19382171
UBC_HUMAN	UBC	physical	23625928
TRIM1_HUMAN	MID2	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
UBC_HUMAN	UBC	physical	21118805
SOCS1_HUMAN	SOCS1	physical	28355105

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.