dbPTM

GLI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GLI2_HUMAN
UniProt AC	P10070
Protein Name	Zinc finger protein GLI2 {ECO:0000305}
Gene Name	GLI2 {ECO:0000312\|HGNC:HGNC:4318}
Organism	Homo sapiens (Human).
Sequence Length	1586
Subcellular Localization	Nucleus . Cytoplasm . Cell projection, cilium . STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. Isoform 1: Nucleus . Isoform 2: Nucle
Protein Description	Functions as transcription regulator in the hedgehog (Hh) pathway. [PubMed: 18455992]
Protein Sequence	METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	METSASATASEKQEA CCCCCCCCHHHHHHH	28.37	-
10	Phosphorylation	TSASATASEKQEAKS CCCCCCHHHHHHHHC	40.76	-
17	Phosphorylation	SEKQEAKSGILEAAG HHHHHHHCCHHHHCC	37.81	29083192
51 (in isoform 2)	Phosphorylation	-	23.77	27732954
51 (in isoform 4)	Phosphorylation	-	23.77	27732954
60 (in isoform 2)	Phosphorylation	-	14.01	26657352
60 (in isoform 4)	Phosphorylation	-	14.01	26657352
65 (in isoform 2)	Phosphorylation	-	26.56	29523821
65 (in isoform 4)	Phosphorylation	-	26.56	29523821
73	Phosphorylation	MRHQEGRYHYEPHSV CCCCCCCCCCCCCCC	21.43	27642862
75	Phosphorylation	HQEGRYHYEPHSVHG CCCCCCCCCCCCCCC	23.40	27642862
90	Phosphorylation	VHGPPALSGSPVISD CCCCCCCCCCCEECC	39.05	29523821
92	Phosphorylation	GPPALSGSPVISDIS CCCCCCCCCEECCCE	16.77	29523821
131	Methylation	PHMEHYLRSVHSSPT HHHHHHHHHHHCCCH	29.48	-
132	Phosphorylation	HMEHYLRSVHSSPTL HHHHHHHHHHCCCHH	22.91	22199227
135	Phosphorylation	HYLRSVHSSPTLSMI HHHHHHHCCCHHHHH	35.54	22199227
136	Phosphorylation	YLRSVHSSPTLSMIS HHHHHHCCCHHHHHH	13.66	22199227
138	Phosphorylation	RSVHSSPTLSMISAA HHHHCCCHHHHHHHH	33.15	22199227
140	Phosphorylation	VHSSPTLSMISAARG HHCCCHHHHHHHHCC	19.29	27732954
143	Phosphorylation	SPTLSMISAARGLSP CCHHHHHHHHCCCCH	13.77	-
146	Methylation	LSMISAARGLSPADV HHHHHHHCCCCHHHH	46.42	-
149	Phosphorylation	ISAARGLSPADVAQE HHHHCCCCHHHHHHH	22.36	30266825
219	Phosphorylation	PVDVSRFSSPRVTPR CCCHHHCCCCCCCCC	38.02	22199227
220	Phosphorylation	VDVSRFSSPRVTPRL CCHHHCCCCCCCCCC	17.64	22199227
224	Phosphorylation	RFSSPRVTPRLSRKR HCCCCCCCCCCCCCC	12.17	22199227
234	Phosphorylation	LSRKRALSISPLSDA CCCCCCCCCCCCCHH	21.75	30266825
236	Phosphorylation	RKRALSISPLSDASL CCCCCCCCCCCHHHH	19.20	30266825
239	Phosphorylation	ALSISPLSDASLDLQ CCCCCCCCHHHHHHH	34.22	30266825
242	Phosphorylation	ISPLSDASLDLQRMI CCCCCHHHHHHHHHH	27.66	30266825
251	Phosphorylation	DLQRMIRTSPNSLVA HHHHHHHCCCCCEEE	37.30	22199227
252	Phosphorylation	LQRMIRTSPNSLVAY HHHHHHCCCCCEEEE	16.55	22199227
255	Phosphorylation	MIRTSPNSLVAYINN HHHCCCCCEEEEECC	27.83	22199227
388	Phosphorylation	PEGLRPASPLALTQG CCCCCCCCCCEECCC	24.11	18455992
498	Phosphorylation	VVHMRRHTGEKPHKC EEEEHHCCCCCCCCC	45.27	23532336
528	Phosphorylation	KTHLRSHTGEKPYVC HHHHHHHCCCCCEEE	48.56	29214152
559	Phosphorylation	KHQNRTHSNEKPYIC HHCCCCCCCCCCEEE	46.18	-
564	Phosphorylation	THSNEKPYICKIPGC CCCCCCCEEEECCCC	29.98	-
575	Phosphorylation	IPGCTKRYTDPSSLR CCCCCCCCCCHHHHH	19.63	29496907
576	Phosphorylation	PGCTKRYTDPSSLRK CCCCCCCCCHHHHHH	45.53	-
579	Phosphorylation	TKRYTDPSSLRKHVK CCCCCCHHHHHHHHH	44.83	19060867
580	Phosphorylation	KRYTDPSSLRKHVKT CCCCCHHHHHHHHHC	37.27	24719451
607	Phosphorylation	RNDVHLRTPLLKENG CCCCCCCCCCHHHCC	25.34	24719451
620	Phosphorylation	NGDSEAGTEPGGPES CCCCCCCCCCCCCCC	46.16	-
627	Phosphorylation	TEPGGPESTEASSTS CCCCCCCCCCCCCHH	34.38	-
631	Phosphorylation	GPESTEASSTSQAVE CCCCCCCCCHHHHHH	28.10	-
725	Phosphorylation	QLRKHMTTMHRFEQL HHHHHHHHHHHHHHH	11.91	-
757	Acetylation	TPHTRNTKLPPLPGS CCCCCCCCCCCCCCC	63.65	23762415
808	Phosphorylation	QLQERRDSSTSTVSS HHHHHHCCCCCCCCC	33.43	28985074
809	Phosphorylation	LQERRDSSTSTVSSA HHHHHCCCCCCCCCE	30.57	28857561
810	Phosphorylation	QERRDSSTSTVSSAY HHHHCCCCCCCCCEE	32.16	28348404
811	Phosphorylation	ERRDSSTSTVSSAYT HHHCCCCCCCCCEEE	28.85	23312004
812	O-linked_Glycosylation	RRDSSTSTVSSAYTV HHCCCCCCCCCEEEE	25.21	30059200
812	Phosphorylation	RRDSSTSTVSSAYTV HHCCCCCCCCCEEEE	25.21	30576142
814	O-linked_Glycosylation	DSSTSTVSSAYTVSR CCCCCCCCCEEEECC	14.89	30059200
814	Phosphorylation	DSSTSTVSSAYTVSR CCCCCCCCCEEEECC	14.89	23312004
818	Phosphorylation	STVSSAYTVSRRSSG CCCCCEEEECCCCCC	16.24	-
820	Phosphorylation	VSSAYTVSRRSSGIS CCCEEEECCCCCCCC	17.74	-
823	Phosphorylation	AYTVSRRSSGISPYF EEEECCCCCCCCCCC	31.63	29802988
824	Phosphorylation	YTVSRRSSGISPYFS EEECCCCCCCCCCCC	38.03	28985074
827	Phosphorylation	SRRSSGISPYFSSRR CCCCCCCCCCCCCCC	19.64	28450419
829	Phosphorylation	RSSGISPYFSSRRSS CCCCCCCCCCCCCCC	14.87	24114839
831	Phosphorylation	SGISPYFSSRRSSEA CCCCCCCCCCCCCCC	19.66	28450419
832	Phosphorylation	GISPYFSSRRSSEAS CCCCCCCCCCCCCCC	23.09	28450419
835	Phosphorylation	PYFSSRRSSEASPLG CCCCCCCCCCCCCCC	31.27	20068231
836	Phosphorylation	YFSSRRSSEASPLGA CCCCCCCCCCCCCCC	35.06	20068231
839	Phosphorylation	SRRSSEASPLGAGRP CCCCCCCCCCCCCCC	19.33	20068231
850	O-linked_Glycosylation	AGRPHNASSADSYDP CCCCCCCCCCCCCCC	31.23	30059200
850	Phosphorylation	AGRPHNASSADSYDP CCCCCCCCCCCCCCC	31.23	20068231
851	O-linked_Glycosylation	GRPHNASSADSYDPI CCCCCCCCCCCCCCC	33.41	30059200
851	Phosphorylation	GRPHNASSADSYDPI CCCCCCCCCCCCCCC	33.41	24043423
854	Phosphorylation	HNASSADSYDPISTD CCCCCCCCCCCCCCC	31.02	24043423
855	Phosphorylation	NASSADSYDPISTDA CCCCCCCCCCCCCCH	26.70	20068231
859	Phosphorylation	ADSYDPISTDASRRS CCCCCCCCCCHHHHC	26.14	20068231
860	Phosphorylation	DSYDPISTDASRRSS CCCCCCCCCHHHHCC	35.98	24043423
863	Phosphorylation	DPISTDASRRSSEAS CCCCCCHHHHCCCHH	30.91	-
866	Phosphorylation	STDASRRSSEASQCS CCCHHHHCCCHHHCC	31.27	20068231
867	Phosphorylation	TDASRRSSEASQCSG CCHHHHCCCHHHCCC	35.06	28857561
870	Phosphorylation	SRRSSEASQCSGGSG HHHCCCHHHCCCCCC	27.89	28857561
873	Phosphorylation	SSEASQCSGGSGLLN CCCHHHCCCCCCCCC	38.25	23532336
876	Phosphorylation	ASQCSGGSGLLNLTP HHHCCCCCCCCCCCH	29.78	28857561
888	Phosphorylation	LTPAQQYSLRAKYAA CCHHHHHHHHHHHHH	13.67	24719451
893	Phosphorylation	QYSLRAKYAAATGGP HHHHHHHHHHHHCCC	10.65	22210691
897	Phosphorylation	RAKYAAATGGPPPTP HHHHHHHHCCCCCCC	37.63	22210691
903	Phosphorylation	ATGGPPPTPLPGLER HHCCCCCCCCCCHHH	43.14	29083192
910	Methylation	TPLPGLERMSLRTRL CCCCCHHHCCHHHHH	25.65	-
916	Methylation	ERMSLRTRLALLDAP HHCCHHHHHHHHCCC	16.13	-
939	Methylation	PRPLGPRRGSDGPTY CCCCCCCCCCCCCCC	52.69	-
941	Phosphorylation	PLGPRRGSDGPTYGH CCCCCCCCCCCCCCC	37.27	28152594
945	Phosphorylation	RRGSDGPTYGHGHAG CCCCCCCCCCCCCCC	47.90	28152594
946	Phosphorylation	RGSDGPTYGHGHAGA CCCCCCCCCCCCCCC	15.40	27732954
970	Phosphorylation	GGGARRASDPVRRPD CCCCCCCCCCCCCCC	40.41	26699800
980	Phosphorylation	VRRPDALSLPRVQRF CCCCCCCCCCCHHHC	37.74	24719451
989	Phosphorylation	PRVQRFHSTHNVNPG CCHHHCCCCCCCCCC	28.75	23312004
990	Phosphorylation	RVQRFHSTHNVNPGP CHHHCCCCCCCCCCC	14.65	23312004
1008	Methylation	CADRRGLRLQSHPST CCCCCCCCCCCCCCC	33.24	-
1011	Phosphorylation	RRGLRLQSHPSTDGG CCCCCCCCCCCCCCC	41.79	28555341
1014	Phosphorylation	LRLQSHPSTDGGLAR CCCCCCCCCCCCCCC	33.43	27732954
1015	Phosphorylation	RLQSHPSTDGGLARG CCCCCCCCCCCCCCC	43.01	29507054
1021	Methylation	STDGGLARGAYSPRP CCCCCCCCCCCCCCC	35.00	-
1025	Phosphorylation	GLARGAYSPRPPSIS CCCCCCCCCCCCCCC	17.56	24719451
1030	Phosphorylation	AYSPRPPSISENVAM CCCCCCCCCCHHHHH	41.24	-
1098	Methylation	TGFSDNPRLPSPGLH CCCCCCCCCCCCCCC	66.54	-
1101	O-linked_Glycosylation	SDNPRLPSPGLHGQR CCCCCCCCCCCCCCC	35.87	OGP
1101	Phosphorylation	SDNPRLPSPGLHGQR CCCCCCCCCCCCCCC	35.87	30266825
1183	Phosphorylation	QKPAFGQYPGYSPQG CCCCCCCCCCCCCCC	10.06	20068231
1186	Phosphorylation	AFGQYPGYSPQGLQA CCCCCCCCCCCCCCC	16.81	29523821
1187	Phosphorylation	FGQYPGYSPQGLQAS CCCCCCCCCCCCCCC	19.36	20068231
1194	Phosphorylation	SPQGLQASPGGLDST CCCCCCCCCCCCCCC	15.89	20068231
1200	Phosphorylation	ASPGGLDSTQPHLQP CCCCCCCCCCCCCCC	33.70	29523821
1201	Phosphorylation	SPGGLDSTQPHLQPR CCCCCCCCCCCCCCC	45.87	29523821
1378	Phosphorylation	PRPPLEPSPTGRHRG CCCCCCCCCCCCHHH	26.22	25850435
1380	Phosphorylation	PPLEPSPTGRHRGVR CCCCCCCCCCHHHHH	51.70	25850435
1387	Methylation	TGRHRGVRAVQQQLA CCCHHHHHHHHHHHH	31.68	-
1397	Methylation	QQQLAYARATGHAMA HHHHHHHHHHCCHHH	21.72	-
1545	Phosphorylation	SQNSSRLTTPRNSLT HCCCCCCCCCCCCCC	33.37	24719451
1546	Phosphorylation	QNSSRLTTPRNSLTL CCCCCCCCCCCCCCC	25.50	27251275
1550	Phosphorylation	RLTTPRNSLTLPSIP CCCCCCCCCCCCCCC	24.82	28348404
1552	Phosphorylation	TTPRNSLTLPSIPAG CCCCCCCCCCCCCCC	36.12	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
388	S	Phosphorylation	Kinase	DYRK2	Q92630	Uniprot
1011	S	Phosphorylation	Kinase	DYRK2	Q92630	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
757	K	Acetylation		23762415
Acetylation at Lys-757 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GLI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CREB1_HUMAN	CREB1	physical	10074179
STK36_HUMAN	STK36	physical	10806483
SKI_HUMAN	SKI	physical	12435627
SPOP_HUMAN	SPOP	physical	25204354
UBP7_HUMAN	USP7	physical	26120032
SUFU_MOUSE	Sufu	physical	26120032
CUL3_HUMAN	CUL3	physical	27477274
SPOP_HUMAN	SPOP	physical	28032859

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
610829	Holoprosencephaly 9 (HPE9)
615849	Culler-Jones syndrome (CJS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GLI2_HUMAN

Related Literatures of Post-Translational Modification

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