FUCO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUCO_HUMAN
• UniProt AC: P04066
• Protein Name: Tissue alpha-L-fucosidase
• Gene Name: FUCA1
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Lysosome.
• Protein Description: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins..
• Protein Sequence: MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRAPGMRSRPAGPAL CCCCCCCCCCCHHHH	33.45	22210691
27	Phosphorylation	LFLGAAESVRRAQPP HHHHHHHHHHHCCCC	19.05	22210691
131	Phosphorylation	FQAAGAKYVVLTTKH HHHCCCCEEEEECCC	8.68	29978859
135	Phosphorylation	GAKYVVLTTKHHEGF CCCEEEEECCCCCCC	23.37	29978859
136	Phosphorylation	AKYVVLTTKHHEGFT CCEEEEECCCCCCCC	24.99	29978859
137	Sumoylation	KYVVLTTKHHEGFTN CEEEEECCCCCCCCC	37.42	-
170	Phosphorylation	DLVGELGTALRKRNI HHHHHHHHHHHHCCC	34.83	14702039
182	Phosphorylation	RNIRYGLYHSLLEWF CCCCHHHHHHHHHHH	5.75	22817900
241	N-linked_Glycosylation	ECPDTYWNSTNFLSW CCCCCCCCCCCHHHH	28.66	19159218
268	N-linked_Glycosylation	VNDRWGQNCSCHHGG EECCCCCCCCCCCCC	18.74	UniProtKB CARBOHYD
382	N-linked_Glycosylation	WRVQWEKNTTSVWYT EEEEEEECCEEEEEE	36.75	19159218
383	O-linked_Glycosylation	RVQWEKNTTSVWYTS EEEEEECCEEEEEEC	31.36	28657654
423	Sulfoxidation	TSTTKITMLGIQGDL ECCCEEEEEEEECEE	3.53	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUCO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUCO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUCO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MARK2_HUMAN	MARK2	physical	28514442
KPCD1_HUMAN	PRKD1	physical	28514442
CHCH5_HUMAN	CHCHD5	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442
TIPRL_HUMAN	TIPRL	physical	28514442
FUCO2_HUMAN	FUCA2	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 230000: Fucosidosis (FUCA1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-241 AND ASN-382, AND MASSSPECTROMETRY.
PubMed: 19159218