IL33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL33_HUMAN
• UniProt AC: O95760
• Protein Name: Interleukin-33
• Gene Name: IL33
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Nucleus . Chromosome . Cytoplasmic vesicle, secretory vesicle . Secreted . Associates with heterochromatin and mitotic chromosomes (PubMed:17185418).
• Protein Description: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. [PubMed: 16286016 Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury]
• Protein Sequence: MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKPKMKYSTNKIST -CCCCCCCCCCCCCC	19.75	29116813
13	Phosphorylation	KYSTNKISTAKWKNT CCCCCCCCCHHHCCH	24.75	29116813
16	Acetylation	TNKISTAKWKNTASK CCCCCCHHHCCHHHH	59.81	7962579
43	Phosphorylation	AKEVCPMYFMKLRSG HHHHHHHHHHHHHHC	5.90	29083192
185	Phosphorylation	DGKMLMVTLSPTKDF CCCEEEEEEECCCCE	13.93	29449344
187	Phosphorylation	KMLMVTLSPTKDFWL CEEEEEEECCCCEEE	22.58	24719451
189	Phosphorylation	LMVTLSPTKDFWLHA EEEEEECCCCEEEEC	39.61	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2A2A_HUMAN	HIST2H2AA3	physical	18688256
H2B2E_HUMAN	HIST2H2BE	physical	18688256
UBP21_HUMAN	USP21	physical	25197364
U17L2_HUMAN	USP17L2	physical	26610488
ILRL1_HUMAN	IL1RL1	physical	19559631

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.