ILRL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ILRL1_HUMAN
• UniProt AC: Q01638
• Protein Name: Interleukin-1 receptor-like 1
• Gene Name: IL1RL1
• Organism: Homo sapiens (Human).
• Sequence Length: 556
• Subcellular Localization: Isoform C: Cell membrane.; Isoform B: Secreted.; Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.; Isoform B: Inhibits IL-33 signaling..
• Protein Sequence: MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	CPRQGKPSYTVDWYY CCCCCCCCEEEEEEE	36.60	30177828
44	Phosphorylation	PRQGKPSYTVDWYYS CCCCCCCEEEEEEEE	21.22	30177828
45	Phosphorylation	RQGKPSYTVDWYYSQ CCCCCCEEEEEEEEC	19.14	30177828
54	N-linked_Glycosylation	DWYYSQTNKSIPTQE EEEEECCCCCCCHHH	28.57	UniProtKB CARBOHYD
56	Phosphorylation	YYSQTNKSIPTQERN EEECCCCCCCHHHHC	35.55	29523821
59	Phosphorylation	QTNKSIPTQERNRVF CCCCCCCHHHHCCEE	41.20	29523821
91	Phosphorylation	IYTCIVRSPTFNRTG EEEEEEECCCCCCCC	19.87	24702127
93	Phosphorylation	TCIVRSPTFNRTGYA EEEEECCCCCCCCCE	34.49	24702127
95	N-linked_Glycosylation	IVRSPTFNRTGYANV EEECCCCCCCCCEEE	42.98	23980170
97	Phosphorylation	RSPTFNRTGYANVTI ECCCCCCCCCEEEEE	35.33	24702127
99	Phosphorylation	PTFNRTGYANVTIYK CCCCCCCCEEEEEEE	8.39	24702127
101	N-linked_Glycosylation	FNRTGYANVTIYKKQ CCCCCCEEEEEEECC	23.99	UniProtKB CARBOHYD
103	Phosphorylation	RTGYANVTIYKKQSD CCCCEEEEEEECCCC	20.56	24702127
105	Phosphorylation	GYANVTIYKKQSDCN CCEEEEEEECCCCCC	11.63	24702127
140	N-linked_Glycosylation	CPTIDLYNWTAPLEW ECCCCCCCCCCCHHH	36.60	23980170
142	Phosphorylation	TIDLYNWTAPLEWFK CCCCCCCCCCHHHHH	18.11	-
164	Phosphorylation	SRYRAHKSFLVIDNV CCHHHCCCEEEEECC	17.59	-
179	Phosphorylation	MTEDAGDYTCKFIHN CCCCCCCEEEEEEEC	17.08	19658100
191	N-linked_Glycosylation	IHNENGANYSVTATR EECCCCCEEEEEEEE	30.89	23980170
193	Phosphorylation	NENGANYSVTATRSF CCCCCEEEEEEEEEE	16.88	-
195	Phosphorylation	NGANYSVTATRSFTV CCCEEEEEEEEEEEE	19.17	-
197	Phosphorylation	ANYSVTATRSFTVKD CEEEEEEEEEEEEEC	19.92	-
232	N-linked_Glycosylation	VEIGKNANLTCSACF EECCCCCCEEEECCC	45.32	UniProtKB CARBOHYD
254	N-linked_Glycosylation	AAVLWQLNGTKITDF HHHHHHHCCCEECCC	40.77	UniProtKB CARBOHYD
273	N-linked_Glycosylation	IQQEEGQNQSFSNGL CCCCCCCCCCCCCHH	50.77	UniProtKB CARBOHYD
370	Phosphorylation	DIAKPYKTRNDGKLY HHCCCCCCCCCCCEE	28.94	-
377	Phosphorylation	TRNDGKLYDAYVVYP CCCCCCEEEEEEEEC	11.30	-
380	Phosphorylation	DGKLYDAYVVYPRNY CCCEEEEEEEECCCC	6.37	22817900
383	Phosphorylation	LYDAYVVYPRNYKSS EEEEEEEECCCCCCC	6.09	22817900
387	Phosphorylation	YVVYPRNYKSSTDGA EEEECCCCCCCCCCH	17.33	-
525	Phosphorylation	ANKRSLNSKFWKHVR CCCHHHCHHHHHHCC	34.23	27251275
533	Phosphorylation	KFWKHVRYQMPVPSK HHHHHCCCCCCCCCC	14.20	27174698
539	Phosphorylation	RYQMPVPSKIPRKAS CCCCCCCCCCCCCHH	43.37	27174698
546	Phosphorylation	SKIPRKASSLTPLAA CCCCCCHHHCCHHHH	28.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL19	Q6PCT2	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ILRL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ILRL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMED1_HUMAN	TMED1	physical	8621446
A4_HUMAN	APP	physical	21832049
MYD88_HUMAN	MYD88	physical	16286016
IRAK4_HUMAN	IRAK4	physical	16286016
IRAK1_HUMAN	IRAK1	physical	16286016
TRAF6_HUMAN	TRAF6	physical	16286016
CLC7A_HUMAN	CLEC7A	physical	25416956
IL33_HUMAN	IL33	physical	19559631

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.