U17L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U17L2_HUMAN
• UniProt AC: Q6R6M4
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 17
• Gene Name: USP17L2
• Organism: Homo sapiens (Human).
• Sequence Length: 530
• Subcellular Localization: Nucleus . Endoplasmic reticulum .
• Protein Description: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection..
• Protein Sequence: MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSEARVDLCDDLAPVARQLAPRKKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEGQWYKMDDAKVTACSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDERLVERATQESTLDHWKFPQEQNKTKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESVNTGTLASLQGRTRRSKGKNKHSKRALLVCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
272	Phosphorylation	KTLTLHTSAKVLILV CEEEEECHHHHHHHH	18.49	-
284	Phosphorylation	ILVLKRFSDVTGNKL HHHHHHHCCCCCCHH	34.89	-
287	Phosphorylation	LKRFSDVTGNKLAKN HHHHCCCCCCHHHCC	39.77	-
358	Phosphorylation	DAKVTACSITSVLSQ CCEEEEEEHHHHHHC	26.83	-
360	Phosphorylation	KVTACSITSVLSQQA EEEEEEHHHHHHCCE	9.11	-
361	Phosphorylation	VTACSITSVLSQQAY EEEEEHHHHHHCCEE	21.28	-
368	Phosphorylation	SVLSQQAYVLFYIQK HHHHCCEEEEEEEEH	8.05	-
399	Phosphorylation	RALGAEDTDRRATQG CCCCCCCCCCHHHHC	23.94	-
504	Phosphorylation	QESVNTGTLASLQGR HHHCHHCHHHHHCCC	19.67	22210691
512	Phosphorylation	LASLQGRTRRSKGKN HHHHCCCCCCCCCCC	36.94	22210691
515	Phosphorylation	LQGRTRRSKGKNKHS HCCCCCCCCCCCCCC	42.33	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U17L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U17L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U17L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SET_HUMAN	SET	physical	19615732
CBX1_HUMAN	CBX1	physical	19615732
U17L7_HUMAN	USP17L7	physical	19615732
MPIP3_HUMAN	CDC25C	physical	20228808
H2AX_HUMAN	H2AFX	physical	24704006
LGMN_HUMAN	LGMN	physical	24610907
SDS3_HUMAN	SUDS3	physical	21239494
HDAC2_HUMAN	HDAC2	physical	26617781
IL33_HUMAN	IL33	physical	26610488
SNAI1_HUMAN	SNAI1	physical	28198361
SNAI1_HUMAN	SNAI1	physical	28067227
CDK4_HUMAN	CDK4	physical	28067227
CDK6_HUMAN	CDK6	physical	28067227
SNAI2_HUMAN	SNAI2	physical	29088851
TWST1_HUMAN	TWIST1	physical	29088851

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.