FXL14_HUMAN - dbPTM
FXL14_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FXL14_HUMAN
UniProt AC Q8N1E6
Protein Name F-box/LRR-repeat protein 14
Gene Name FBXL14
Organism Homo sapiens (Human).
Sequence Length 418
Subcellular Localization Cytoplasm .
Protein Description Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1..
Protein Sequence METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKEARGDFSPLFTVRTRGSSRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
60PhosphorylationHLRRANPSLFPSLQA
HHHHCCCCCCHHHHH		42.31-
64PhosphorylationANPSLFPSLQARGIR
CCCCCCHHHHHCCCC		26.27-
118PhosphorylationAFVQEIGSLRALNLS
HHHHHHHHHHHHCHH		21.9724719451
228PhosphorylationKHISRGLTGLRLLNL
HHHHCCCHHHHHCCC		36.6724719451
236PhosphorylationGLRLLNLSFCGGISD
HHHHCCCEECCCCCH		19.8825022875
242PhosphorylationLSFCGGISDAGLLHL
CEECCCCCHHHHHHH		25.3625022875
250PhosphorylationDAGLLHLSHMGSLRS
HHHHHHHHHCCCCCC		10.7325022875
254PhosphorylationLHLSHMGSLRSLNLR
HHHHHCCCCCCCCCC		17.0325022875
257PhosphorylationSHMGSLRSLNLRSCD
HHCCCCCCCCCCCCC		27.2322210691
267PhosphorylationLRSCDNISDTGIMHL
CCCCCCCCHHHHHHH		35.0622210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FXL14_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FXL14_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FXL14_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNAI1_HUMANSNAI1physical
19955572
DICER_HUMANDICER1physical
24035498
PPR21_HUMANPPP1R21physical
28514442
TTC9C_HUMANTTC9Cphysical
28514442
QORL1_HUMANCRYZL1physical
28514442
CUL1_HUMANCUL1physical
28514442
SC11C_HUMANSEC11Cphysical
28514442
SGT1_HUMANSUGT1physical
28514442
AAGAB_HUMANAAGABphysical
28514442
ITPR1_HUMANITPR1physical
28514442
CSN2_HUMANCOPS2physical
28514442
SPCS2_HUMANSPCS2physical
28514442
CSN6_HUMANCOPS6physical
28514442
CSN1_HUMANGPS1physical
28514442
DAAM1_HUMANDAAM1physical
28514442
FSTL1_HUMANFSTL1physical
28514442
CSN7A_HUMANCOPS7Aphysical
28514442
DICER_HUMANDICER1physical
28514442
GBB2_HUMANGNB2physical
28514442
SKP1_HUMANSKP1physical
28514442
CSN3_HUMANCOPS3physical
28514442
PPM1A_HUMANPPM1Aphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FXL14_HUMAN

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Related Literatures of Post-Translational Modification

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