EPHAA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPHAA_HUMAN
• UniProt AC: Q5JZY3
• Protein Name: Ephrin type-A receptor 10
• Gene Name: EPHA10
• Organism: Homo sapiens (Human).
• Sequence Length: 1008
• Subcellular Localization: Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 3: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .
• Protein Description: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5..
• Protein Sequence: METCAGPHPLRLFLCRMQLCLALLLGPWRPGTAEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRRGFHLAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESAFSTLVEVAGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDFCEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQIRAASPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAIVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGGDAHDEEELYFHFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAKSVTLERSLGGGRFGELCCGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIHSILSKMVQDPEPPKCALTTCPRPPTPLADRAFSTFPSFGSVGAWLEALDLCRYKDSFAAAGYGSLEAVAEMTAQDLVSLGISLAEHREALLSGISALQARVLQLQGQGVQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	IFVELQFTLRDCSSI EEEEEEEEEECCCCC	14.13	24719451
203	Phosphorylation	GACVALVSVRVYYKQ HHHHHEEEHHHHHHH	12.69	24719451
311	N-linked_Glycosylation	EHSRALENASTFCVC HHHHHHHHCCEEEEE	39.79	UniProtKB CARBOHYD
314	Phosphorylation	RALENASTFCVCQDS HHHHHCCEEEEECCH	20.74	30576142
327	Phosphorylation	DSYARSPTDPPSASC CHHCCCCCCCCCCCC	63.48	30576142
335	Phosphorylation	DPPSASCTRPPSAPR CCCCCCCCCCCCCCC	43.65	30576142
365	Phosphorylation	RWLPPADSGGRSDVT EECCCCCCCCCCCCE	45.30	29262532
369	Phosphorylation	PADSGGRSDVTYSLL CCCCCCCCCCEEEEE	39.44	29262532
372	Phosphorylation	SGGRSDVTYSLLCLR CCCCCCCEEEEEEHH	16.63	29262532
373	Phosphorylation	GGRSDVTYSLLCLRC CCCCCCEEEEEEHHC	9.36	29262532
374	Phosphorylation	GRSDVTYSLLCLRCG CCCCCEEEEEEHHCC	12.90	29262532
473	Phosphorylation	EPQSVSLSWREPIPA CCCCEEEEECCCCCC	19.31	24719451
486	N-linked_Glycosylation	PAGAPGANDTEYEIR CCCCCCCCCCEEEEE	63.75	UniProtKB CARBOHYD
569	Phosphorylation	QSPAIVVTVVTISAL CCCCEEEEEEHHHHH	9.81	-
644	Phosphorylation	AKELDAKSVTLERSL HHHCCCCEEEEEECC	23.27	23403867
646	Phosphorylation	ELDAKSVTLERSLGG HCCCCEEEEEECCCC	29.96	23403867
650	Phosphorylation	KSVTLERSLGGGRFG CEEEEEECCCCCCHH	23.22	23403867
697	Phosphorylation	GFLAEALTLGQFDHS HHHHHHHHHCCCCCC	35.57	22210691
756	Phosphorylation	GLLPGLASAMKYLSE HHHHHHHHHHHHHHH	33.66	24275569
787	Phosphorylation	SDLVCKISGFGRGPR CCEEEECCCCCCCCC	17.35	23312004
898	Phosphorylation	PRFSQIHSILSKMVQ CCHHHHHHHHHHHCC	27.18	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPHAA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPHAA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPHAA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EPHAA_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.