dbPTM

HLAE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HLAE_HUMAN
UniProt AC	P13747
Protein Name	HLA class I histocompatibility antigen, alpha chain E
Gene Name	HLA-E
Organism	Homo sapiens (Human).
Sequence Length	358
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules..
Protein Sequence	MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LSEALALTQTWAGSH HHHHHHHHHHHCCCC	20.53	27732954
19	Phosphorylation	EALALTQTWAGSHSL HHHHHHHHHCCCCCC	16.43	27732954
23	Phosphorylation	LTQTWAGSHSLKYFH HHHHHCCCCCCEEEE	11.36	27732954
25	Phosphorylation	QTWAGSHSLKYFHTS HHHCCCCCCEEEEEE	28.40	27732954
48	Phosphorylation	PRFISVGYVDDTQFV CCEEEEEEECCCEEE	9.88	-
107	N-linked_Glycosylation	RTLRGYYNQSEAGSH HHHCCCCCCCCCCCC	30.34	19349973
134	Phosphorylation	DRRFLRGYEQFAYDG CCCHHCCCCCCEECC	10.50	23401153
139	Phosphorylation	RGYEQFAYDGKDYLT CCCCCCEECCCCCEE	26.90	23401153
142	Ubiquitination	EQFAYDGKDYLTLNE CCCEECCCCCEECCH	40.06	21890473
142	Ubiquitination	EQFAYDGKDYLTLNE CCCEECCCCCEECCH	40.06	-
155	O-linked_Glycosylation	NEDLRSWTAVDTAAQ CHHHHHCHHHHHHHH	20.32	OGP
167	Ubiquitination	AAQISEQKSNDASEA HHHHHHHHCCCCHHH	47.37	21890473
167	Ubiquitination	AAQISEQKSNDASEA HHHHHHHHCCCCHHH	47.37	-
191	Ubiquitination	TCVEWLHKYLEKGKE HHHHHHHHHHHHCCC	49.73	-
195	Ubiquitination	WLHKYLEKGKETLLH HHHHHHHHCCCEEEE	73.09	-
197	Ubiquitination	HKYLEKGKETLLHLE HHHHHHCCCEEEECC	59.60	-
197	Ubiquitination	HKYLEKGKETLLHLE HHHHHHCCCEEEECC	59.60	21890473
207	Ubiquitination	LLHLEPPKTHVTHHP EEECCCCCCCCCCCC	63.08	-
216	Phosphorylation	HVTHHPISDHEATLR CCCCCCCCCHHHHHH	37.05	-
264	Ubiquitination	AGDGTFQKWAAVVVP CCCCCEECEEEEEEC	34.31	21906983
272	Phosphorylation	WAAVVVPSGEEQRYT EEEEEECCCCCEEEE	47.42	-
278	Phosphorylation	PSGEEQRYTCHVQHE CCCCCEEEEEEEEEC	17.26	-
292	O-linked_Glycosylation	EGLPEPVTLRWKPAS CCCCCCEEEEECCCC	22.71	OGP
333	Phosphorylation	AVIWRKKSSGGKGGS EEEEEECCCCCCCCC	36.93	-
337	Ubiquitination	RKKSSGGKGGSYSKA EECCCCCCCCCCCCC	64.72	-
337	Ubiquitination	RKKSSGGKGGSYSKA EECCCCCCCCCCCCC	64.72	21890473
340	Phosphorylation	SSGGKGGSYSKAEWS CCCCCCCCCCCCCCC	34.60	-
341	Phosphorylation	SGGKGGSYSKAEWSD CCCCCCCCCCCCCCC	19.91	-
342	Phosphorylation	GGKGGSYSKAEWSDS CCCCCCCCCCCCCCC	27.38	-
343	Ubiquitination	GKGGSYSKAEWSDSA CCCCCCCCCCCCCCC	41.93	21890473
343	Ubiquitination	GKGGSYSKAEWSDSA CCCCCCCCCCCCCCC	41.93	21890473
347	Phosphorylation	SYSKAEWSDSAQGSE CCCCCCCCCCCCCCC	17.13	23403867
349	Phosphorylation	SKAEWSDSAQGSESH CCCCCCCCCCCCCCC	19.58	23403867
353	Phosphorylation	WSDSAQGSESHSL-- CCCCCCCCCCCCC--	24.68	23401153
355	Phosphorylation	DSAQGSESHSL---- CCCCCCCCCCC----	21.77	23403867
357	Phosphorylation	AQGSESHSL------ CCCCCCCCC------	45.08	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HLAE_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HLAE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HLAE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2MG_HUMAN	B2M	physical	9605335
ATF6A_HUMAN	ATF6	physical	26186194
TECT2_HUMAN	TCTN2	physical	26186194
HLAF_HUMAN	HLA-F	physical	26186194
1A02_HUMAN	HLA-A	physical	26186194
1A03_HUMAN	HLA-A	physical	26186194
1A01_HUMAN	HLA-A	physical	26186194
1A26_HUMAN	HLA-A	physical	26186194
NDST2_HUMAN	NDST2	physical	26186194
NDST1_HUMAN	NDST1	physical	26186194
RTL8C_HUMAN	FAM127A	physical	26186194
MET13_HUMAN	METTL13	physical	26186194
ASPH_HUMAN	ASPH	physical	26186194
BIG2_HUMAN	ARFGEF2	physical	26186194
DPB1_HUMAN	HLA-DPB1	physical	26186194
PLXA3_HUMAN	PLXNA3	physical	26186194
GAS6_HUMAN	GAS6	physical	26186194
PBIP1_HUMAN	PBXIP1	physical	26186194
HMR1_HUMAN	MR1	physical	26186194
ATF6B_HUMAN	ATF6B	physical	26186194
E2AK3_HUMAN	EIF2AK3	physical	26186194
PTCD2_HUMAN	PTCD2	physical	26186194
ABCA3_HUMAN	ABCA3	physical	26186194
PLXB2_HUMAN	PLXNB2	physical	26186194
WDFY3_HUMAN	WDFY3	physical	26186194
ITA6_HUMAN	ITGA6	physical	26186194
CNNM1_HUMAN	CNNM1	physical	26186194
ECEL1_HUMAN	ECEL1	physical	26186194
MGT5A_HUMAN	MGAT5	physical	26186194
TM131_HUMAN	TMEM131	physical	26186194
FCGRN_HUMAN	FCGRT	physical	26186194
CNTP3_HUMAN	CNTNAP3	physical	26186194
EPHB4_HUMAN	EPHB4	physical	26186194
ATP23_HUMAN	XRCC6BP1	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
BACE2_HUMAN	BACE2	physical	26186194
KCNJ8_HUMAN	KCNJ8	physical	26186194
MA2A2_HUMAN	MAN2A2	physical	26186194
MADD_HUMAN	MADD	physical	26186194
GLT12_HUMAN	GALNT12	physical	26186194
EDEM2_HUMAN	EDEM2	physical	26186194
ECEL1_HUMAN	ECEL1	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
FCGRN_HUMAN	FCGRT	physical	28514442
ITA6_HUMAN	ITGA6	physical	28514442
ASPH_HUMAN	ASPH	physical	28514442
EPHB4_HUMAN	EPHB4	physical	28514442
BACE2_HUMAN	BACE2	physical	28514442
RTL8C_HUMAN	FAM127A	physical	28514442
WDFY3_HUMAN	WDFY3	physical	28514442
GAS6_HUMAN	GAS6	physical	28514442
CNNM1_HUMAN	CNNM1	physical	28514442
PLXA3_HUMAN	PLXNA3	physical	28514442
MET13_HUMAN	METTL13	physical	28514442
HMR1_HUMAN	MR1	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
LRC24_HUMAN	LRRC24	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
HLAF_HUMAN	HLA-F	physical	28514442
GLT12_HUMAN	GALNT12	physical	28514442
ATF6B_HUMAN	ATF6B	physical	28514442
ATP23_HUMAN	XRCC6BP1	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
TECT2_HUMAN	TCTN2	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
PTCD2_HUMAN	PTCD2	physical	28514442
ATF6A_HUMAN	ATF6	physical	28514442
LRIG1_HUMAN	LRIG1	physical	28514442
MGT5A_HUMAN	MGAT5	physical	28514442

Drug and Disease Associations

Kegg Disease
H00344	Leprosy; Hansen disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HLAE_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107, AND MASSSPECTROMETRY.	19349973 [Abstract]