BICD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BICD1_HUMAN
• UniProt AC: Q96G01
• Protein Name: Protein bicaudal D homolog 1
• Gene Name: BICD1
• Organism: Homo sapiens (Human).
• Sequence Length: 975
• Subcellular Localization: Golgi apparatus.
• Protein Description: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex..
• Protein Sequence: MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESFLLKGPPSMSEFIQGHRLSKEKRLTVAPPDCQQPAASVPPQCSQLAGRQDCPTVSPDTALPEEQPHSSSQCAPLHCLSKPPHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AAEEVLQTVDHYKTE CHHHHHHHHHHHHHH	24.60	20049867
13	Phosphorylation	VLQTVDHYKTEIERL HHHHHHHHHHHHHHH	18.36	20049867
14	Ubiquitination	LQTVDHYKTEIERLT HHHHHHHHHHHHHHH	35.94	29967540
15	Phosphorylation	QTVDHYKTEIERLTK HHHHHHHHHHHHHHH	34.72	24043423
21	Phosphorylation	KTEIERLTKELTETT HHHHHHHHHHHHHHH	28.79	20049867
22	Ubiquitination	TEIERLTKELTETTH HHHHHHHHHHHHHHH	56.15	29967540
45	Methylation	GLVVLEEKLTLKQQY CCEEEEEECCHHHHH	37.08	-
47	Phosphorylation	VVLEEKLTLKQQYDE EEEEEECCHHHHHHH	42.87	24719451
52	Phosphorylation	KLTLKQQYDELEAEY ECCHHHHHHHHHHHH	14.64	28122231
61	Phosphorylation	ELEAEYDSLKQELEQ HHHHHHHHHHHHHHH	36.24	-
76	Phosphorylation	LKEAFGQSFSIHRKV HHHHHCCCCCHHHHH	22.72	28555341
82	Ubiquitination	QSFSIHRKVAEDGET CCCCHHHHHHCCCCC	31.47	29967540
101	Ubiquitination	LLQESASKEAYYLGK HHHHHHCHHHHHHHH	46.19	29967540
117	Ubiquitination	LEMQNELKQSRAVVT HHHHHHHHHCCEEEC	39.80	-
184	Ubiquitination	EENITLQKLVSTLKQ HHCCCHHHHHHHHHH	54.70	29967540
188	Phosphorylation	TLQKLVSTLKQNQVE CHHHHHHHHHHCCCC	30.41	23403867
190	Ubiquitination	QKLVSTLKQNQVEYE HHHHHHHHHCCCCCC	47.49	29967540
215	Phosphorylation	EETVLLNSQLEDAIR HHHHHHCHHHHHHHH	35.79	-
224	Ubiquitination	LEDAIRLKEIAEHQL HHHHHHHHHHHHHHH	36.91	29967540
239	Ubiquitination	EEALETLKNEREQKN HHHHHHHHHHHHHHH	65.27	29967540
300	Phosphorylation	LVKLNGDYRTPTLRK EEECCCCCCCCCCCC	20.13	-
302	Phosphorylation	KLNGDYRTPTLRKGE ECCCCCCCCCCCCCC	17.88	-
304	Phosphorylation	NGDYRTPTLRKGESL CCCCCCCCCCCCCCC	38.28	-
307	Ubiquitination	YRTPTLRKGESLNPV CCCCCCCCCCCCCCH	70.87	29967540
310	Phosphorylation	PTLRKGESLNPVSDL CCCCCCCCCCCHHHH	41.96	28857561
315	Phosphorylation	GESLNPVSDLFSELN CCCCCCHHHHHHHCC	29.83	28122231
319	Phosphorylation	NPVSDLFSELNISEI CCHHHHHHHCCHHHH	48.77	28122231
328	Ubiquitination	LNISEIQKLKQQLMQ CCHHHHHHHHHHHHH	64.41	29967540
330	Ubiquitination	ISEIQKLKQQLMQVE HHHHHHHHHHHHHHH	42.93	29967540
340	Ubiquitination	LMQVEREKAILLANL HHHHHHHHHHHHHHH	47.12	29967540
358	Ubiquitination	QTQLEHTKGALTEQH HHHHHHHHCHHHHHH	44.06	29967540
399	Phosphorylation	DGEKGRDSGEEAHDY CCCCCCCCCCCCCCE	46.90	30576142
406	Phosphorylation	SGEEAHDYEVDINGL CCCCCCCEEEECCCE	14.16	28796482
420	Phosphorylation	LEILECKYRVAVTEV EEEEEEEEEEEEEEH	23.21	22210691
425	Phosphorylation	CKYRVAVTEVIDLKA EEEEEEEEEHHHHHH	18.13	22210691
443	Ubiquitination	ALKEKYNKSVENYTD HHHHHHHHCHHCCCC	53.43	-
448	Phosphorylation	YNKSVENYTDEKAKY HHHCHHCCCCHHHHH	11.32	22817900
452	Ubiquitination	VENYTDEKAKYESKI HHCCCCHHHHHHHHH	53.65	-
454	Ubiquitination	NYTDEKAKYESKIQM CCCCHHHHHHHHHHH	61.69	-
455	Phosphorylation	YTDEKAKYESKIQMY CCCHHHHHHHHHHHH	30.23	22817900
471	Acetylation	EQVTSLEKTTKESGE HHHHCHHHHHHHHHH	67.78	7629253
472	Phosphorylation	QVTSLEKTTKESGEK HHHCHHHHHHHHHHH	33.45	30631047
473	Phosphorylation	VTSLEKTTKESGEKM HHCHHHHHHHHHHHH	43.83	30631047
479	Acetylation	TTKESGEKMAHMEKE HHHHHHHHHHHHHHH	44.93	7707145
485	Ubiquitination	EKMAHMEKELQKMTS HHHHHHHHHHHHHHH	57.03	-
537	Phosphorylation	PNRVMLDYYRQSRVT CCCCHHHHHHHCCCC	9.15	-
538	Phosphorylation	NRVMLDYYRQSRVTR CCCHHHHHHHCCCCC	11.22	-
546	Phosphorylation	RQSRVTRSGSLKGPD HHCCCCCCCCCCCCC	24.30	23401153
548	Phosphorylation	SRVTRSGSLKGPDDP CCCCCCCCCCCCCCC	28.31	30266825
560	Phosphorylation	DDPRGLLSPRLARRG CCCCCCCCHHHHHCC	17.02	22167270
569	Phosphorylation	RLARRGVSSPVETRT HHHHCCCCCCCCCCC	31.58	25159151
570	Phosphorylation	LARRGVSSPVETRTS HHHCCCCCCCCCCCC	30.47	25159151
574	Phosphorylation	GVSSPVETRTSSEPV CCCCCCCCCCCCCCC	39.21	29396449
576	Phosphorylation	SSPVETRTSSEPVAK CCCCCCCCCCCCCCH	43.98	-
585	Phosphorylation	SEPVAKESTEASKEP CCCCCHHCCCCCCCC	30.73	17139249
586	Phosphorylation	EPVAKESTEASKEPS CCCCHHCCCCCCCCC	36.34	25850435
589	Phosphorylation	AKESTEASKEPSPTK CHHCCCCCCCCCCCC	31.18	25850435
593	Phosphorylation	TEASKEPSPTKTPTI CCCCCCCCCCCCCCC	46.42	29255136
595	Phosphorylation	ASKEPSPTKTPTISP CCCCCCCCCCCCCCC	52.46	29255136
597	Phosphorylation	KEPSPTKTPTISPVI CCCCCCCCCCCCCCC	28.30	17139249
599	Phosphorylation	PSPTKTPTISPVITA CCCCCCCCCCCCCCC	39.04	25159151
601	Phosphorylation	PTKTPTISPVITAPP CCCCCCCCCCCCCCC	18.65	25159151
605	Phosphorylation	PTISPVITAPPSSPV CCCCCCCCCCCCCCC	33.09	26074081
609	Phosphorylation	PVITAPPSSPVLDTS CCCCCCCCCCCCCCH	46.33	29255136
610	Phosphorylation	VITAPPSSPVLDTSD CCCCCCCCCCCCCHH	25.46	29255136
615	Phosphorylation	PSSPVLDTSDIRKEP CCCCCCCCHHHCCCC	24.92	29255136
616	Phosphorylation	SSPVLDTSDIRKEPM CCCCCCCHHHCCCCC	30.61	29255136
620	Ubiquitination	LDTSDIRKEPMNIYN CCCHHHCCCCCCCCC	67.51	29967540
678	Ubiquitination	MEEILKLKSLLSTKR HHHHHHHHHHHCCCH	37.15	-
682	Phosphorylation	LKLKSLLSTKREQIA HHHHHHHCCCHHHHH	36.86	24719451
684	Ubiquitination	LKSLLSTKREQIATL HHHHHCCCHHHHHHH	51.03	-
701	Phosphorylation	VLKANKQTAEVALAN HHHHCHHHHHHHHHH	26.79	21406692
710	Acetylation	EVALANLKNKYENEK HHHHHHHHHHHHCHH	51.72	7671021
713	Phosphorylation	LANLKNKYENEKAMV HHHHHHHHHCHHHHH	33.12	22817900
732	Ubiquitination	TKLRNELKALKEDAA HHHHHHHHHHHHHHH	45.56	-
743	Phosphorylation	EDAATFSSLRAMFAT HHHHHHHHHHHHHHH	20.06	24719451
778	Phosphorylation	DEKKTLNTLLRMAIQ HHHHHHHHHHHHHHH	30.22	25247763
787	Ubiquitination	LRMAIQQKLALTQRL HHHHHHHHHHHHHHH	21.25	-
804	Phosphorylation	LEFDHEQSRRSKGKL HCCCHHHHHHHCCCC	27.03	23401153
823 (in isoform 4)	Phosphorylation	-	37.16	-
829 (in isoform 4)	Phosphorylation	-	3.54	-
844	Phosphorylation	LHSQGPQTPNIRVSS ECCCCCCCCCEEECC	22.80	25159151
860	Phosphorylation	TQRKRQFSPSLCDQS CCCCCCCCHHHCCCC	12.77	27732954
865 (in isoform 3)	Phosphorylation	-	55.58	18220336
866 (in isoform 3)	Phosphorylation	-	40.10	18220336
902	Phosphorylation	LKGPPSMSEFIQGHR HCCCCCHHHHHCCCC	33.42	30576142
911	Phosphorylation	FIQGHRLSKEKRLTV HHCCCCCCCCCCEEE	38.43	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BICD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BICD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BICD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	21988832
MK14_HUMAN	MAPK14	physical	21988832
RAB6A_HUMAN	RAB6A	physical	16473624

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.