JOS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JOS2_HUMAN
• UniProt AC: Q8TAC2
• Protein Name: Josephin-2
• Gene Name: JOSD2
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme..
• Protein Sequence: MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRLAPDSRLNPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQGLCEVLLVVTKEVEEKGSWLRTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	QAPGAQPSPPTVYHE CCCCCCCCCCCCCCH	31.28	25159151
118	Phosphorylation	PVSLGLLSLPLRRRH CCCHHHHCCCCHHCC	32.74	24719451
142	Ubiquitination	VYYNLDSKLRAPEAL EEEECCCCCCCCHHH	41.48	21890473
181	Ubiquitination	VTKEVEEKGSWLRTD EECCHHHCCCCCCCC	44.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JOS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JOS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JOS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC2A_HUMAN	TRAPPC2	physical	19615732
TPC2B_HUMAN	TRAPPC2	physical	19615732
SMCA2_HUMAN	SMARCA2	physical	19615732
SAHH2_HUMAN	AHCYL1	physical	19615732
SAHH3_HUMAN	AHCYL2	physical	19615732
TYSD1_HUMAN	TYSND1	physical	19615732
UBC_HUMAN	UBC	physical	23625928
PA2GA_HUMAN	PLA2G2A	physical	22118674
UBC_HUMAN	UBC	physical	21118805
SAHH3_HUMAN	AHCYL2	physical	26186194
SAHH2_HUMAN	AHCYL1	physical	26186194
TPC2A_HUMAN	TRAPPC2	physical	26186194
TPC2B_HUMAN	TRAPPC2	physical	26186194
DUS28_HUMAN	DUSP28	physical	26186194
HBB_HUMAN	HBB	physical	26186194
TYSD1_HUMAN	TYSND1	physical	26186194
SAHH3_HUMAN	AHCYL2	physical	28514442
TPC2A_HUMAN	TRAPPC2	physical	28514442
TPC2B_HUMAN	TRAPPC2	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442
TYSD1_HUMAN	TYSND1	physical	28514442
HBB_HUMAN	HBB	physical	28514442
DUS28_HUMAN	DUSP28	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.