MSX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSX1_HUMAN
• UniProt AC: P28360
• Protein Name: Homeobox protein MSX-1
• Gene Name: MSX1
• Organism: Homo sapiens (Human).
• Sequence Length: 303
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity..
• Protein Sequence: MAPAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESALAPSEGVQAAGGSAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Sumoylation	APAADMTSLPLGVKV CCCCCCCCCCCCCEE	37.80	-
15	Sumoylation	TSLPLGVKVEDSAFG CCCCCCCEEEECCCC	17.48	-
55	Phosphorylation	EGAKPKVSPSLLPFS CCCCCCCCHHHCCCC	14.95	30108239
57	Phosphorylation	AKPKVSPSLLPFSVE CCCCCCHHHCCCCHH	5.23	30108239
110	Phosphorylation	LGAPDAPSSPRPLGH CCCCCCCCCCCCCCC	23.60	28348404
111	Phosphorylation	GAPDAPSSPRPLGHF CCCCCCCCCCCCCCC	21.35	28348404
127	Sumoylation	VGGLLKLPEDALVKA ECCEECCCHHHCEEC	47.49	-
136	Phosphorylation	DALVKAESPEKPERT HHCEECCCCCCCCCC	55.40	28985074
143	Phosphorylation	SPEKPERTPWMQSPR CCCCCCCCCCCCCCC	25.17	23312004
148	Phosphorylation	ERTPWMQSPRFSPPP CCCCCCCCCCCCCCC	33.70	23312004
152	Phosphorylation	WMQSPRFSPPPARRL CCCCCCCCCCCHHHC	41.44	30266825
160	Phosphorylation	PPPARRLSPPACTLR CCCHHHCCCCCCCCC	7.45	30266825
165	Phosphorylation	RLSPPACTLRKHKTN HCCCCCCCCCCCCCC	39.72	23312004
171	Phosphorylation	CTLRKHKTNRKPRTP CCCCCCCCCCCCCCC	31.14	-
180	Phosphorylation	RKPRTPFTTAQLLAL CCCCCCCCHHHHHHH	18.90	-
198	Phosphorylation	FRQKQYLSIAERAEF HHHHHHHHHHHHHHH	52.89	24247654
210	Phosphorylation	AEFSSSLSLTETQVK HHHCCCCCCCHHHHH	6.74	24247654
231	Ubiquitination	RAKAKRLQEAELEKL HHHHHHHHHHHHHHH	67.06	21906983
237	Ubiquitination	LQEAELEKLKMAAKP HHHHHHHHHHHHHCC	22.79	22817900
239	Ubiquitination	EAELEKLKMAAKPML HHHHHHHHHHHCCCC	9.64	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBP_HUMAN	CREBBP	genetic	10215616
TBP_HUMAN	TBP	genetic	10215616
SP1_HUMAN	SP1	genetic	10215616
LHX2_HUMAN	LHX2	physical	9697309
MSX1_HUMAN	MSX1	physical	9111364
MSX2_HUMAN	MSX2	physical	9111364
DLX2_HUMAN	DLX2	physical	9111364
DLX5_HUMAN	DLX5	physical	9111364
HXC8_HUMAN	HOXC8	physical	9111364
TBP_HUMAN	TBP	physical	9111364
TBP_HUMAN	TBP	physical	8700832
TLE2_HUMAN	TLE2	physical	20211142
NMNA1_HUMAN	NMNAT1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.