LHX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LHX2_HUMAN
• UniProt AC: P50458
• Protein Name: LIM/homeobox protein Lhx2
• Gene Name: LHX2
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)..
• Protein Sequence: MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLFHSLSGPEVH ---CCCCCCCCHHHC	19.52	29978859
7	Phosphorylation	-MLFHSLSGPEVHGV -CCCCCCCCHHHCCH	56.15	29978859
31	Phosphorylation	SEAPAISSAIDRGDT CCCCCHHHHCCCCCC	24.11	28787133
41	Phosphorylation	DRGDTETTMPSISSD CCCCCCCCCCCCCCC	22.35	-
46	Phosphorylation	ETTMPSISSDRAALC CCCCCCCCCCHHHHH	30.44	-
47	Phosphorylation	TTMPSISSDRAALCA CCCCCCCCCHHHHHC	29.46	-
125	Phosphorylation	CHLGISASEMVMRAR CCCCCCHHHHHHHHH	21.31	30576142
145	Phosphorylation	LNCFTCTTCNKMLTT CCCCCCCCCCCCCCC	19.07	30576142
213	Phosphorylation	ANPLGLPYYNGVGTV CCCCCCCCCCCCCCC	18.01	-
219	Phosphorylation	PYYNGVGTVQKGRPR CCCCCCCCCCCCCCC	19.84	-
230	Phosphorylation	GRPRKRKSPGPGADL CCCCCCCCCCCCCCH	38.84	28842319
245	Phosphorylation	AAYNAALSCNENDAE HHHHHHHCCCCCCHH	15.35	28985074
262	Phosphorylation	DRDQPYPSSQKTKRM CCCCCCCCCHHHHHH	39.29	29449344
263	Phosphorylation	RDQPYPSSQKTKRMR CCCCCCCCHHHHHHH	31.06	29449344
280	Phosphorylation	FKHHQLRTMKSYFAI HHHHHHHHHHHHHHH	37.23	23403867
303	Phosphorylation	LKQLAQKTGLTKRVL HHHHHHHHCCCHHHH	25.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:31801865

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LHX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LHX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CITE2_HUMAN	CITED2	physical	10593900

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.