CITE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CITE2_HUMAN
• UniProt AC: Q99967
• Protein Name: Cbp/p300-interacting transactivator 2
• Gene Name: CITED2
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Nucleus . Colocalizes with EP300 in dot-like structures.
• Protein Description: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region..
• Protein Sequence: MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	MMAMNHGRFPDGTNG CCCCCCCCCCCCCCC	32.16	-
85	Phosphorylation	VNGGHPPSALAPAAR CCCCCCHHHHCCCHH	40.12	-
166	Phosphorylation	KHSGGSSTPGGSGGS CCCCCCCCCCCCCCC	27.87	-
175	Phosphorylation	GGSGGSSTPGGSGSS CCCCCCCCCCCCCCC	27.87	-
266	Phosphorylation	FVCKQQPSRVSC--- HHHCCCCCCCCC---	40.76	28102081
269	Phosphorylation	KQQPSRVSC------ CCCCCCCCC------	17.01	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
85	S	Phosphorylation	Kinase	ERK2	P28482	PSP
166	T	Phosphorylation	Kinase	ERK2	P28482	PSP
175	T	Phosphorylation	Kinase	ERK2	P28482	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CITE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CITE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2A_HUMAN	TFAP2A	physical	12586840
AP2C_HUMAN	TFAP2C	physical	12586840
AP2A_HUMAN	TFAP2A	physical	11744733
AP2B_HUMAN	TFAP2B	physical	11744733
AP2C_HUMAN	TFAP2C	physical	11744733
EP300_HUMAN	EP300	physical	10593900
TBP_HUMAN	TBP	physical	10593900
SMAD3_HUMAN	SMAD3	physical	16619037
EP300_HUMAN	EP300	physical	12778114
FBXL5_HUMAN	FBXL5	physical	25956243
EP300_HUMAN	EP300	physical	25956243

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.