SOX10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX10_HUMAN
• UniProt AC: P56693
• Protein Name: Transcription factor SOX-10
• Gene Name: SOX10
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Cytoplasm . Nucleus . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. [PubMed: 21965087]
• Protein Sequence: MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTETAGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAEEQDLSEVELSPV CCCCCCCCCCCCCCC	48.13	29255136
13	Phosphorylation	DLSEVELSPVGSEEP CCCCCCCCCCCCCCC	12.20	29255136
17	Phosphorylation	VELSPVGSEEPRCLS CCCCCCCCCCCCCCC	38.73	29255136
24	Phosphorylation	SEEPRCLSPGSAPSL CCCCCCCCCCCCCCC	30.73	29255136
27	Phosphorylation	PRCLSPGSAPSLGPD CCCCCCCCCCCCCCC	40.15	29255136
30	Phosphorylation	LSPGSAPSLGPDGGG CCCCCCCCCCCCCCC	45.75	29255136
40	Phosphorylation	PDGGGGGSGLRASPG CCCCCCCCCCCCCCC	37.62	27251789
45	Phosphorylation	GGSGLRASPGPGELG CCCCCCCCCCCCCCC	24.77	29255136
55	Sumoylation	PGELGKVKKEQQDGE CCCCCCCCHHHCCCC	54.82	-
55	Sumoylation	PGELGKVKKEQQDGE CCCCCCCCHHHCCCC	54.82	-
121	Ubiquitination	WAQAARRKLADQYPH HHHHHHHHHHHHCCC	42.34	21890473
136	Ubiquitination	LHNAELSKTLGKLWR CCHHHHHHHHHHHHH	61.46	-
140	Ubiquitination	ELSKTLGKLWRLLNE HHHHHHHHHHHHHCC	48.25	21890473
140	Ubiquitination	ELSKTLGKLWRLLNE HHHHHHHHHHHHHCC	48.25	21890473
140	Acetylation	ELSKTLGKLWRLLNE HHHHHHHHHHHHHCC	48.25	133803
140	Ubiquitination	ELSKTLGKLWRLLNE HHHHHHHHHHHHHCC	48.25	21890473
171	Phosphorylation	HKKDHPDYKYQPRRR HCCCCCCCCCCCCCC	18.95	-
172	Ubiquitination	KKDHPDYKYQPRRRK CCCCCCCCCCCCCCC	44.80	21890473
208	Acetylation	AAIQAHYKSAHLDHR HHHHHHHHHCCCCCC	31.16	20167786
209	Phosphorylation	AIQAHYKSAHLDHRH HHHHHHHHCCCCCCC	17.47	27251275
221	Phosphorylation	HRHPGEGSPMSDGNP CCCCCCCCCCCCCCC	17.09	29255136
224	Phosphorylation	PGEGSPMSDGNPEHP CCCCCCCCCCCCCCC	45.83	29255136
232	Phosphorylation	DGNPEHPSGQSHGPP CCCCCCCCCCCCCCC	51.91	29255136
235	Phosphorylation	PEHPSGQSHGPPTPP CCCCCCCCCCCCCCC	33.66	29255136
240	Phosphorylation	GQSHGPPTPPTTPKT CCCCCCCCCCCCCCH	45.06	29255136
243	Phosphorylation	HGPPTPPTTPKTELQ CCCCCCCCCCCHHHC	57.86	29255136
244	Phosphorylation	GPPTPPTTPKTELQS CCCCCCCCCCHHHCC	28.67	29255136
246	Sumoylation	PTPPTTPKTELQSGK CCCCCCCCHHHCCCC	53.17	-
246	Sumoylation	PTPPTTPKTELQSGK CCCCCCCCHHHCCCC	53.17	-
247	Phosphorylation	TPPTTPKTELQSGKA CCCCCCCHHHCCCCC	43.03	25002506
251	Phosphorylation	TPKTELQSGKADPKR CCCHHHCCCCCCCCC	55.69	25002506
344	Phosphorylation	PPGVALPTVSPPGVD CCCCCCCCCCCCCCC	34.17	29255136
346	Phosphorylation	GVALPTVSPPGVDAK CCCCCCCCCCCCCCC	28.05	29255136
357	Sumoylation	VDAKAQVKTETAGPQ CCCCEEEECCCCCCC	28.67	-
357	Sumoylation	VDAKAQVKTETAGPQ CCCCEEEECCCCCCC	28.67	-
437	Phosphorylation	PSQRPLYTAISDPSP CCCCCCEEECCCCCC	25.79	25002506
440	Phosphorylation	RPLYTAISDPSPSGP CCCEEECCCCCCCCC	40.79	25002506
443	Phosphorylation	YTAISDPSPSGPQSH EEECCCCCCCCCCCC	36.37	25002506
445	Phosphorylation	AISDPSPSGPQSHSP ECCCCCCCCCCCCCC	68.40	25002506
449	Phosphorylation	PSPSGPQSHSPTHWE CCCCCCCCCCCCCCC	29.12	25002506
451	Phosphorylation	PSGPQSHSPTHWEQP CCCCCCCCCCCCCCC	36.42	25002506
453	Phosphorylation	GPQSHSPTHWEQPVY CCCCCCCCCCCCCCE	42.51	25002506
460	Phosphorylation	THWEQPVYTTLSRP- CCCCCCCEEECCCC-	10.74	25002506
461	Phosphorylation	HWEQPVYTTLSRP-- CCCCCCEEECCCC--	22.84	25002506
462	Phosphorylation	WEQPVYTTLSRP--- CCCCCEEECCCC---	12.68	25002506
464	Phosphorylation	QPVYTTLSRP----- CCCEEECCCC-----	40.18	25002506

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX3_HUMAN	PAX3	physical	12668617
NMI_HUMAN	NMI	physical	16214168
FBXW7_HUMAN	FBXW7	physical	26461473

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611584: Waardenburg syndrome 2E (WS2E)
• 613266: Waardenburg syndrome 4C (WS4C)
• 609136: Peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome and Hirschsprung disease (PCWH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-45, AND MASSSPECTROMETRY.
PubMed: 19369195