HDHD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDHD2_HUMAN
• UniProt AC: Q9H0R4
• Protein Name: Haloacid dehalogenase-like hydrolase domain-containing protein 2
• Gene Name: HDHD2
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Protein Sequence: MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDFKGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	LKRLRGASVIIRFVT HHHHCCCEEEEEECC	19.37	23312004
46	Phosphorylation	SVIIRFVTNTTKESK EEEEEECCCCCHHHH	24.92	26437602
48	Phosphorylation	IIRFVTNTTKESKQD EEEECCCCCHHHHHH	29.85	23312004
49	Phosphorylation	IRFVTNTTKESKQDL EEECCCCCHHHHHHH	34.58	26437602
50	Succinylation	RFVTNTTKESKQDLL EECCCCCHHHHHHHH	58.93	-
50	Acetylation	RFVTNTTKESKQDLL EECCCCCHHHHHHHH	58.93	25953088
50	Succinylation	RFVTNTTKESKQDLL EECCCCCHHHHHHHH	58.93	-
52	Phosphorylation	VTNTTKESKQDLLER CCCCCHHHHHHHHHH	36.85	23312004
53	Ubiquitination	TNTTKESKQDLLERL CCCCHHHHHHHHHHH	49.26	-
77	Phosphorylation	DEIFTSLTAARSLLE HHHHHHHHHHHHHHH	20.31	24260401
92 (in isoform 2)	Ubiquitination	-	4.70	21890473
145	Ubiquitination	APLIAIHKARYYKRK CCEEEEEECCEEECC	28.57	-
145	Acetylation	APLIAIHKARYYKRK CCEEEEEECCEEECC	28.57	25953088
179	Ubiquitination	TKATVVGKPEKTFFL CCCEECCCCHHEEEH	38.09	-
179	Acetylation	TKATVVGKPEKTFFL CCCEECCCCHHEEEH	38.09	91325
182	Ubiquitination	TVVGKPEKTFFLEAL EECCCCHHEEEHHHH	60.19	21890473
182	Acetylation	TVVGKPEKTFFLEAL EECCCCHHEEEHHHH	60.19	25953088
182 (in isoform 1)	Ubiquitination	-	60.19	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDHD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDHD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDHD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LHPP_HUMAN	LHPP	physical	26186194
H13_HUMAN	HIST1H1D	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
RASH_HUMAN	HRAS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.