ITM2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITM2A_HUMAN
• UniProt AC: O43736
• Protein Name: Integral membrane protein 2A
• Gene Name: ITM2A
• Organism: Homo sapiens (Human).
• Sequence Length: 263
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Sequence: MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGLSFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MVKIAFNTPT -----CCEEEECCCC	27.33	29967540
8	Phosphorylation	MVKIAFNTPTAVQKE CCEEEECCCCHHCHH	18.63	23684312
10	Phosphorylation	KIAFNTPTAVQKEEA EEEECCCCHHCHHHH	37.10	30576142
14	Ubiquitination	NTPTAVQKEEARQDV CCCCHHCHHHHHHHH	51.42	21906983
28	Phosphorylation	VEALLSRTVRTQILT HHHHHHHHHHHHHHC	15.80	21406692
31	Phosphorylation	LLSRTVRTQILTGKE HHHHHHHHHHHCCCE	18.67	21406692
35	Phosphorylation	TVRTQILTGKELRVA HHHHHHHCCCEEEEE	48.08	21406692
37	Ubiquitination	RTQILTGKELRVATQ HHHHHCCCEEEEEEC	48.63	22817900
37 (in isoform 2)	Ubiquitination	-	48.63	-
46	Ubiquitination	LRVATQEKEGSSGRC EEEEECCCCCCCHHH	58.52	30230243
112	Phosphorylation	EPNFLPVTEEADIRE CCCCCCCCCCCCCCC	26.60	-
132	O-linked_Glycosylation	IIDVPVPSFSDSDPA EEEECCCCCCCCCCC	37.30	OGP
134	O-linked_Glycosylation	DVPVPSFSDSDPAAI EECCCCCCCCCCCHH	40.31	OGP
166	N-linked_Glycosylation	NCYLMPLNTSIVMPP CCEEEECCCCEECCC	26.38	UniProtKB CARBOHYD
182	Ubiquitination	NLVELFGKLASGRYL CHHHHHHHHHCCCCC	33.28	-
199	Ubiquitination	TYVVREDLVAVEEIR EEEEECCEEEHHHHH	1.97	29967540
238	Ubiquitination	DLLLGFNKRAIDKCW HHHHCCCHHHHHHHH	40.73	-
243	Ubiquitination	FNKRAIDKCWKIRHF CCHHHHHHHHHHCCC	35.56	29967540
246	Ubiquitination	RAIDKCWKIRHFPNE HHHHHHHHHCCCCCC	39.06	-
258	Phosphorylation	PNEFIVETKICQE-- CCCCEEEEECCCC--	18.15	21964256
259	Ubiquitination	NEFIVETKICQE--- CCCEEEEECCCC---	28.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITM2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITM2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITM2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH36_HUMAN	KLHL36	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
DOA_HUMAN	HLA-DOA	physical	28514442
RSPRY_HUMAN	RSPRY1	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
DJC16_HUMAN	DNAJC16	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
ATP7B_HUMAN	ATP7B	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442
ATP7A_HUMAN	ATP7A	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.