NTF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTF3_HUMAN
• UniProt AC: P20783
• Protein Name: Neurotrophin-3
• Gene Name: NTF3
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Secreted.
• Protein Description: Seems to promote the survival of visceral and proprioceptive sensory neurons..
• Protein Sequence: MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	2.73	27732954
6 (in isoform 2)	Phosphorylation	-	6.81	27732954
6	Phosphorylation	--MSILFYVIFLAYL --CCHHHHHHHHHHH	6.81	24043423
12	Phosphorylation	FYVIFLAYLRGIQGN HHHHHHHHHHHHCCC	10.08	24043423
15 (in isoform 2)	Phosphorylation	-	17.61	-
49	Phosphorylation	DILKNKLSKQMVDVK HHHCCHHHHHCCCHH	23.58	23684312
59	Phosphorylation	MVDVKENYQSTLPKA CCCHHHHHHHCCCCC	12.63	24719451
62	Phosphorylation	VKENYQSTLPKAEAP HHHHHHHCCCCCCCC	31.39	24719451
99	Phosphorylation	LLRQQRRYNSPRVLL HHHHHHHHCCCCEEC	23.37	27251275
101	Phosphorylation	RQQRRYNSPRVLLSD HHHHHHCCCCEECCC	12.73	24719451
107	Phosphorylation	NSPRVLLSDSTPLEP CCCCEECCCCCCCCC	25.92	27251275
109	Phosphorylation	PRVLLSDSTPLEPPP CCEECCCCCCCCCCC	28.66	27251275
110	Phosphorylation	RVLLSDSTPLEPPPL CEECCCCCCCCCCCE	36.56	27251275
123	Phosphorylation	PLYLMEDYVGSPVVA CEEECCCCCCCCEEC	8.06	-
131	N-linked_Glycosylation	VGSPVVANRTSRRKR CCCCEECCCCHHHHH	35.83	UniProtKB CARBOHYD
219	Phosphorylation	HWNSQCKTSQTYVRA CCCCCCCCCHHHHHH	33.42	22798277
222	Phosphorylation	SQCKTSQTYVRALTS CCCCCCHHHHHHHHC	24.61	22798277
223	Phosphorylation	QCKTSQTYVRALTSE CCCCCHHHHHHHHCC	4.74	22798277
251	Phosphorylation	TSCVCALSRKIGRT- HHHHHHHHHHHCCC-	17.01	27251789

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTRK1_HUMAN	NTRK1	physical	8621424
NTRK2_HUMAN	NTRK2	physical	8621424
NTRK3_HUMAN	NTRK3	physical	8621424
TNR16_RAT	Ngfr	physical	18596692
LAMB1_HUMAN	LAMB1	physical	26186194
PYGB_HUMAN	PYGB	physical	26186194
PYGL_HUMAN	PYGL	physical	26186194
ITIH3_HUMAN	ITIH3	physical	26186194
MD2BP_HUMAN	MAD2L1BP	physical	26186194
MD2BP_HUMAN	MAD2L1BP	physical	28514442
PYGL_HUMAN	PYGL	physical	28514442
PYGB_HUMAN	PYGB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.