NTRK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTRK3_HUMAN
• UniProt AC: Q16288
• Protein Name: NT-3 growth factor receptor
• Gene Name: NTRK3
• Organism: Homo sapiens (Human).
• Sequence Length: 839
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation..
• Protein Sequence: MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	N-linked_Glycosylation	SNGNASINITDISRN CCCCEEEEEEECCCC	28.72	UniProtKB CARBOHYD
79	N-linked_Glycosylation	NITDISRNITSIHIE EEEECCCCCEEEEEC	34.79	UniProtKB CARBOHYD
90	Phosphorylation	IHIENWRSLHTLNAV EEECCHHHCCCCCCC	19.00	22210691
93	Phosphorylation	ENWRSLHTLNAVDME CCHHHCCCCCCCCHH	27.31	22210691
109	Phosphorylation	YTGLQKLTIKNSGLR HHCCCEEEECCCCCC	36.62	22210691
113	Phosphorylation	QKLTIKNSGLRSIQP CEEEECCCCCCCCCC	33.91	27174698
117	Phosphorylation	IKNSGLRSIQPRAFA ECCCCCCCCCCCHHC	30.53	27174698
131	Phosphorylation	AKNPHLRYINLSSNR CCCCCEEEEECCCCC	10.67	-
133	N-linked_Glycosylation	NPHLRYINLSSNRLT CCCEEEEECCCCCCH	25.57	UniProtKB CARBOHYD
151	Phosphorylation	WQLFQTLSLRELQLE HHHHHHCCHHHHHHH	28.86	24719451
163	N-linked_Glycosylation	QLEQNFFNCSCDIRW HHHHCCCCCCCCHHH	16.80	UniProtKB CARBOHYD
203	N-linked_Glycosylation	QLPLFRMNISQCDLP CCCEEEEEHHHCCCC	26.89	UniProtKB CARBOHYD
218	N-linked_Glycosylation	EISVSHVNLTVREGD CCEEEEEEEEEEECC	25.27	UniProtKB CARBOHYD
220	Phosphorylation	SVSHVNLTVREGDNA EEEEEEEEEEECCCE	16.59	-
232	N-linked_Glycosylation	DNAVITCNGSGSPLP CCEEEEECCCCCCCC	38.73	UniProtKB CARBOHYD
259	N-linked_Glycosylation	NTHQTNLNWTNVHAI CCCCCCCCCEEEEEE	45.67	UniProtKB CARBOHYD
267	N-linked_Glycosylation	WTNVHAINLTLVNVT CEEEEEEEEEEEEEE	27.96	UniProtKB CARBOHYD
272	N-linked_Glycosylation	AINLTLVNVTSEDNG EEEEEEEEEECCCCC	34.17	UniProtKB CARBOHYD
294	N-linked_Glycosylation	ENVVGMSNASVALTV ECCCCCCCCEEEEEE	27.61	UniProtKB CARBOHYD
375	N-linked_Glycosylation	PTHYNNGNYTLIAKN CCCCCCCCEEEEEEC	28.83	UniProtKB CARBOHYD
377	Phosphorylation	HYNNGNYTLIAKNPL CCCCCCEEEEEECCC	18.71	29978859
386	Phosphorylation	IAKNPLGTANQTING EEECCCCCCCCEECC	30.07	22817900
388	N-linked_Glycosylation	KNPLGTANQTINGHF ECCCCCCCCEECCEE	39.09	UniProtKB CARBOHYD
493	Phosphorylation	HGITTPSSLDAGPDT CCCCCHHHCCCCCCE	31.32	-
516	Phosphorylation	PVIENPQYFRQGHNC CCCCCHHHHCCCCCC	11.28	22322096
558	Phosphorylation	KVFLAECYNLSPTKD HEEEEHHHCCCCCCC	15.62	25884760
561	Phosphorylation	LAECYNLSPTKDKML EEHHHCCCCCCCCCH	27.21	24719451
575	Acetylation	LVAVKALKDPTLAAR HHHHHHHCCCCHHHH	67.53	25038526
597 (in isoform 2)	Phosphorylation	-	31.59	-
604 (in isoform 2)	Phosphorylation	-	11.70	-
606 (in isoform 2)	Phosphorylation	-	1.94	-
701	Phosphorylation	KIGDFGMSRDVYSTD EECCCCCCCCCCCCC	26.21	-
705	Phosphorylation	FGMSRDVYSTDYYRL CCCCCCCCCCCEEEC	15.33	22817900
709	Phosphorylation	RDVYSTDYYRLFNPS CCCCCCCEEECCCCC	7.20	22817900
710	Phosphorylation	DVYSTDYYRLFNPSG CCCCCCEEECCCCCC	12.03	22817900
730	Phosphorylation	WCEVGGHTMLPIRWM EEEECCEEEEEEECC	24.55	30177828
741	Phosphorylation	IRWMPPESIMYRKFT EECCCCHHEEEEEEC	20.59	30177828
744	Phosphorylation	MPPESIMYRKFTTES CCCHHEEEEEECCHH	14.69	30177828
800	Phosphorylation	RVCPKEVYDVMLGCW CCCCHHHHHHHHCCC	12.15	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTRK3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTRK3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTRK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SQSTM_HUMAN	SQSTM1	physical	12471037
A4_HUMAN	APP	physical	21832049
ACK1_HUMAN	TNK2	physical	23598414
SH3B4_HUMAN	SH3BP4	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
C1GLT_HUMAN	C1GALT1	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
CF120_HUMAN	C6orf120	physical	28514442
MTOR_HUMAN	MTOR	physical	28514442
LEG1_HUMAN	LGALS1	physical	28514442
PTCD2_HUMAN	PTCD2	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
PHAG1_HUMAN	PAG1	physical	28514442
EFR3A_HUMAN	EFR3A	physical	28514442
TBC24_HUMAN	TBC1D24	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
TM192_HUMAN	TMEM192	physical	28514442
INT7_HUMAN	INTS7	physical	28514442
MYCPP_HUMAN	DENND4A	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
MRRP3_HUMAN	KIAA0391	physical	28514442
EPHA2_HUMAN	EPHA2	physical	28514442
ATP7B_HUMAN	ATP7B	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
EHD4_HUMAN	EHD4	physical	28514442
RPTOR_HUMAN	RPTOR	physical	28514442
HEAT6_HUMAN	HEATR6	physical	28514442
S39AB_HUMAN	SLC39A11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.