TULP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TULP2_HUMAN
• UniProt AC: O00295
• Protein Name: Tubby-related protein 2
• Gene Name: TULP2
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Cytoplasm. Secreted. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway..
• Protein Sequence: MSQDNDTLMRDILGHELAAMRLQKLEQQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGERGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVENGSVSPPPFKQSPRIRRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKKREASESTGTNSSAAHNEELSKALKGEGGTDSDHMRHEASLAIRSPCPGLEEDMEAYVLRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICLSSFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Phosphorylation	LSWLPDNSDAELEEV HHCCCCCCCCCCEEE	45.65	-
190	Phosphorylation	DMGDAHKSPNMGPNP CCCHHCCCCCCCCCC	16.19	-
226	Phosphorylation	KREASESTGTNSSAA HHHHHHHCCCCCHHH	43.93	-
230	Phosphorylation	SESTGTNSSAAHNEE HHHCCCCCHHHCHHH	22.61	-
231	Phosphorylation	ESTGTNSSAAHNEEL HHCCCCCHHHCHHHH	31.38	-
305	Phosphorylation	DKGLFPLYYLYLETS CCCCEEEEEEEHHCC	7.52	23663014
306	Phosphorylation	KGLFPLYYLYLETSD CCCEEEEEEEHHCCH	9.14	23663014
308	Phosphorylation	LFPLYYLYLETSDSL CEEEEEEEHHCCHHH	6.08	23663014
311	Phosphorylation	LYYLYLETSDSLQRF EEEEEHHCCHHHHHH	34.93	23663014
312	Phosphorylation	YYLYLETSDSLQRFL EEEEHHCCHHHHHHH	18.81	23663014
314	Phosphorylation	LYLETSDSLQRFLLA EEHHCCHHHHHHHHH	26.60	23663014
330	Phosphorylation	RKRRRSKTSNYLISL CCCCCCCCCCEEEEC	24.37	-
331	Phosphorylation	KRRRSKTSNYLISLD CCCCCCCCCEEEECC	27.49	-
380	Phosphorylation	REHLTRNTARIRQEL HHHHHHHHHHHHHHH	17.64	23532336
399	Phosphorylation	YEPNVLGYLGPRKMT CCCCCCCEECCCEEE	12.34	22817900
429	Phosphorylation	QPLNEQESLLSRYQR ECCCHHHHHHHHHHH	34.01	24719451
432	Phosphorylation	NEQESLLSRYQRGDK CHHHHHHHHHHHCCC	33.95	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TULP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TULP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TULP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTR9_HUMAN	CTR9	physical	28514442
HDAC6_HUMAN	HDAC6	physical	28514442
PAF1_HUMAN	PAF1	physical	28514442
LEO1_HUMAN	LEO1	physical	28514442
ZSWM8_HUMAN	ZSWIM8	physical	28514442
JIP2_HUMAN	MAPK8IP2	physical	28514442
IF122_HUMAN	IFT122	physical	28514442
WDR19_HUMAN	WDR19	physical	28514442
SIK2_HUMAN	SIK2	physical	28514442
IF140_HUMAN	IFT140	physical	28514442
CDC73_HUMAN	CDC73	physical	28514442
WDR35_HUMAN	WDR35	physical	28514442
ZNHI2_HUMAN	ZNHIT2	physical	28514442
MYO5C_HUMAN	MYO5C	physical	28514442
AMER1_HUMAN	AMER1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
FANCJ_HUMAN	BRIP1	physical	28514442
TRI32_HUMAN	TRIM32	physical	28514442
NSE4A_HUMAN	NSMCE4A	physical	28514442
KIF1B_HUMAN	KIF1B	physical	28514442
ESPL1_HUMAN	ESPL1	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
DPOA2_HUMAN	POLA2	physical	28514442
IQGA3_HUMAN	IQGAP3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.