dbPTM

SIRB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIRB1_HUMAN
UniProt AC	O00241
Protein Name	Signal-regulatory protein beta-1
Gene Name	SIRPB1
Organism	Homo sapiens (Human).
Sequence Length	398
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK..
Protein Sequence	MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Ubiquitination	RELIYNQKEGHFPRV CHHEECCCCCCCCCE	63.12	-
97	Ubiquitination	TTVSELTKRNNLDFS EEHHHHHHHCCCEEE	66.79	-
119	Phosphorylation	PADAGTYYCVKFRKG HHCCCEEEEEEECCC	7.21	-
135	Phosphorylation	PDDVEFKSGAGTELS CCCCEEECCCCCEEE	38.91	29978859
139	Phosphorylation	EFKSGAGTELSVRAK EEECCCCCEEEEEEC	32.97	29978859
142	Phosphorylation	SGAGTELSVRAKPSA CCCCCEEEEEECCCC	11.88	29978859
148	Phosphorylation	LSVRAKPSAPVVSGP EEEEECCCCCEEECC	44.49	30243723
153	Phosphorylation	KPSAPVVSGPAVRAT CCCCCEEECCEEECC	39.01	30243723
182	Ubiquitination	SPRDITLKWFKNGNE CCCCEEEEEEECCCC	41.77	-
182 (in isoform 1)	Ubiquitination	-	41.77	21890473
191	Phosphorylation	FKNGNELSDFQTNVD EECCCCCCCCCCCCC	30.15	-
244	N-linked_Glycosylation	DPLRGTANLSEAIRV CCCCCCCCHHHHCCC	43.89	16335952
269	N-linked_Glycosylation	MRAENQANVTCQVSN CCHHHCCCCEEEEEC	21.62	UniProtKB CARBOHYD
291	N-linked_Glycosylation	LTWLENGNVSRTETA EEEEECCCCCCEEEC	39.92	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIRB1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIRB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIRB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TYOBP_HUMAN	TYROBP	physical	10604985
TYOBP_HUMAN	TYROBP	physical	10940905
KSYK_HUMAN	SYK	physical	10940905
RBPMS_HUMAN	RBPMS	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIRB1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-244, AND MASSSPECTROMETRY.	16335952 [Abstract]